Literature DB >> 31391891

Anti-biofilm activity of quinazoline derivatives against Mycobacterium smegmatis.

Karlie E Cox1, Christian Melander1.   

Abstract

Bacteria employ a number of mechanisms to resist the effects of antibiotics, including the formation of biofilms. We explored the anti-biofilm capabilities of a library of compounds based upon a 2-aminoquinazoline (2-AQ) scaffold against Mycobacterium smegmatis. This study resulted in the identification of 2-AQ derivatives with biofilm inhibition activity against M. smegmatis.

Entities:  

Year:  2019        PMID： 31391891      PMCID： PMC6640545          DOI： 10.1039/c9md00156e

Source DB:  PubMed          Journal:  Medchemcomm        ISSN： 2040-2503            Impact factor:   3.597


  12 in total

Review 1.  Riddle of biofilm resistance.

Authors:  K Lewis
Journal:  Antimicrob Agents Chemother       Date:  2001-04       Impact factor: 5.191

2.  2-Aminopyrimidine as a novel scaffold for biofilm modulation.

Authors:  Erick A Lindsey; Roberta J Worthington; Cristina Alcaraz; Christian Melander
Journal:  Org Biomol Chem       Date:  2012-02-02       Impact factor: 3.876

Review 3.  Mechanisms of biofilm resistance to antimicrobial agents.

Authors:  T F Mah; G A O'Toole
Journal:  Trends Microbiol       Date:  2001-01       Impact factor: 17.079

4.  Growth of Mycobacterium tuberculosis biofilms.

Authors:  Kathleen Kulka; Graham Hatfull; Anil K Ojha
Journal:  J Vis Exp       Date:  2012-02-15       Impact factor: 1.355

5.  Small-molecule suppression of β-lactam resistance in multidrug-resistant gram-negative pathogens.

Authors:  Christopher M Brackett; Roberta J Melander; Il Hwan An; Aparna Krishnamurthy; Richele J Thompson; John Cavanagh; Christian Melander
Journal:  J Med Chem       Date:  2014-08-28       Impact factor: 7.446

6.  The discovery of N-1 substituted 2-aminobenzimidazoles as zinc-dependent S. aureus biofilm inhibitors.

Authors:  Erick A Lindsey; Christopher M Brackett; Trey Mullikin; Cristina Alcaraz; Christian Melander
Journal:  Medchemcomm       Date:  2012-09-18       Impact factor: 3.597

7.  A novel ruthenium-catalyzed dehydrogenative synthesis of 2-arylquinazolines from 2-aminoaryl methanols and benzonitriles.

Authors:  Mengmeng Chen; Min Zhang; Biao Xiong; Zhenda Tan; Wan Lv; Huanfeng Jiang
Journal:  Org Lett       Date:  2014-11-10       Impact factor: 6.005

8.  Evaluation of the Mycobacterium smegmatis and BCG models for the discovery of Mycobacterium tuberculosis inhibitors.

Authors:  Mudassar Altaf; Christopher H Miller; David S Bellows; Ronan O'Toole
Journal:  Tuberculosis (Edinb)       Date:  2010-10-12       Impact factor: 3.131

Review 9.  Biofilms: survival mechanisms of clinically relevant microorganisms.

Authors:  Rodney M Donlan; J William Costerton
Journal:  Clin Microbiol Rev       Date:  2002-04       Impact factor: 26.132

10.  Reversal of Mycobacterium tuberculosis phenotypic drug resistance by 2-aminoimidazole-based small molecules.

Authors:  David F Ackart; Erick A Lindsey; Brendan K Podell; Roberta J Melander; Randall J Basaraba; Christian Melander
Journal:  Pathog Dis       Date:  2014-02-24       Impact factor: 3.166
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  5 in total

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2.  Second-Generation Meridianin Analogues Inhibit the Formation of Mycobacterium smegmatis Biofilms and Sensitize Polymyxin-Resistant Gram-Negative Bacteria to Colistin.

Authors:  Michael J Zeiler; Roberta J Melander; Christian Melander
Journal:  ChemMedChem       Date:  2020-08-03       Impact factor: 3.466

3.  Synthesis and biofilm inhibition studies of 2-(2-amino-6-arylpyrimidin-4-yl)quinazolin-4(3H)-ones.

Authors:  Sivappa Rasapalli; Zachary F Murphy; Vamshikrishna Reddy Sammeta; James A Golen; Alexander W Weig; Roberta J Melander; Christian Melander; Prathyushakrishna Macha; Milana C Vasudev
Journal:  Bioorg Med Chem Lett       Date:  2020-09-12       Impact factor: 2.823

4.  2-Aminoimidazoles Inhibit Mycobacterium abscessus Biofilms in a Zinc-Dependent Manner.

Authors:  Juan M Belardinelli; Wei Li; Kevin H Martin; Michael J Zeiler; Elena Lian; Charlotte Avanzi; Crystal J Wiersma; Tuan Vu Nguyen; Bhanupriya Angala; Vinicius C N de Moura; Victoria Jones; Bradley R Borlee; Christian Melander; Mary Jackson
Journal:  Int J Mol Sci       Date:  2022-03-09       Impact factor: 5.923

Review 5.  Strategies and Approaches for Discovery of Small Molecule Disruptors of Biofilm Physiology.

Authors:  Michael A Trebino; Rahul D Shingare; John B MacMillan; Fitnat H Yildiz
Journal:  Molecules       Date:  2021-07-29       Impact factor: 4.411
  5 in total

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