PURPOSE: The authors report a novel measurement strategy to obtain both rest and stress blood flow during a single, relatively short, scan session. METHODS: Measurement of rest-stress myocardial blood flow with long-lived tracers usually requires separate scan sessions to remove the confounding effects of residual radioactivity concentration in the blood and tissue. The innovation of this method is to treat the rest-stress scan as a single entity in which the flow parameters change due to pharmacological challenge. With this approach the fate of a tracer molecule is naturally accounted for, no matter if it was introduced during the rest or stress phase of the study. Two new dual-injection kinetic models are considered that represent the response to pharmacological stress as a transitional or transient increase of myocardial blood flow. The authors present the theory of the method followed by the specific application of the theory to (18)F-Flurpiridaz, a new myocardial flow-imaging agent. RESULTS: Myocardial blood flow was accurately and precisely estimated from a single-scan rest∕stress study for the long half-lived tracer (18)F-Flurpiridaz. By accounting for the time-dependence of the kinetic parameters, the proposed models achieved good accuracy and precision (5%) under different vasodilators and different ischemic states. CONCLUSIONS: Detailed simulations predict that accurate and precise rest-stress blood flow measurements can be obtained in 20-30 min.
PURPOSE: The authors report a novel measurement strategy to obtain both rest and stress blood flow during a single, relatively short, scan session. METHODS: Measurement of rest-stress myocardial blood flow with long-lived tracers usually requires separate scan sessions to remove the confounding effects of residual radioactivity concentration in the blood and tissue. The innovation of this method is to treat the rest-stress scan as a single entity in which the flow parameters change due to pharmacological challenge. With this approach the fate of a tracer molecule is naturally accounted for, no matter if it was introduced during the rest or stress phase of the study. Two new dual-injection kinetic models are considered that represent the response to pharmacological stress as a transitional or transient increase of myocardial blood flow. The authors present the theory of the method followed by the specific application of the theory to (18)F-Flurpiridaz, a new myocardial flow-imaging agent. RESULTS: Myocardial blood flow was accurately and precisely estimated from a single-scan rest∕stress study for the long half-lived tracer (18)F-Flurpiridaz. By accounting for the time-dependence of the kinetic parameters, the proposed models achieved good accuracy and precision (5%) under different vasodilators and different ischemic states. CONCLUSIONS: Detailed simulations predict that accurate and precise rest-stress blood flow measurements can be obtained in 20-30 min.
Authors: Manuel D Cerqueira; Neil J Weissman; Vasken Dilsizian; Alice K Jacobs; Sanjiv Kaul; Warren K Laskey; Dudley J Pennell; John A Rumberger; Thomas Ryan; Mario S Verani Journal: J Nucl Cardiol Date: 2002 Mar-Apr Impact factor: 5.952
Authors: R E Stewart; M Schwaiger; E Molina; J Popma; G M Gacioch; M Kalus; S Squicciarini; Z R al-Aouar; A Schork; D E Kuhl Journal: Am J Cardiol Date: 1991-06-15 Impact factor: 2.778
Authors: S C Huang; M M Bahn; J R Barrio; J M Hoffman; N Satyamurthy; R A Hawkins; J C Mazziotta; M E Phelps Journal: J Cereb Blood Flow Metab Date: 1989-12 Impact factor: 6.200
Authors: Padmaja Yalamanchili; Eric Wexler; Megan Hayes; Ming Yu; Jody Bozek; Mikhail Kagan; Heike S Radeke; Michael Azure; Ajay Purohit; David S Casebier; Simon P Robinson Journal: J Nucl Cardiol Date: 2007-10-22 Impact factor: 5.952
Authors: Timothy M Bateman; Gary V Heller; A Iain McGhie; John D Friedman; James A Case; Jan R Bryngelson; Ginger K Hertenstein; Kelly L Moutray; Kimberly Reid; S James Cullom Journal: J Nucl Cardiol Date: 2006 Jan-Feb Impact factor: 5.952
Authors: Nicolas J Guehl; Marc D Normandin; Dustin W Wooten; Guy Rozen; Arkadiusk Sitek; Jeremy Ruskin; Timothy M Shoup; Leon M Ptaszek; Georges El Fakhri; Nathaniel M Alpert Journal: Eur J Nucl Med Mol Imaging Date: 2017-04-01 Impact factor: 9.236
Authors: Nicolas J Guehl; Marc D Normandin; Dustin W Wooten; Guy Rozen; Jeremy N Ruskin; Timothy M Shoup; Jonghye Woo; Leon M Ptaszek; Georges El Fakhri; Nathaniel M Alpert Journal: Med Phys Date: 2017-07-18 Impact factor: 4.071
Authors: Yoann Petibon; Nicolas J Guehl; Timothy G Reese; Behzad Ebrahimi; Marc D Normandin; Timothy M Shoup; Nathaniel M Alpert; Georges El Fakhri; Jinsong Ouyang Journal: Phys Med Biol Date: 2016-12-20 Impact factor: 3.609
Authors: Edward P Ficaro; Venkatesh L Murthy; Alexis Poitrasson-Rivière; Jonathan B Moody; Jennifer M Renaud; Tomoe Hagio; Liliana Arida-Moody; Christopher Buckley; Richard L Weinberg Journal: J Nucl Cardiol Date: 2021-11-15 Impact factor: 3.872
Authors: Nicolas J Guehl; Matthieu Pelletier-Galarneau; Dustin W Wooten; J Luis Guerrero; Aurélie Kas; Marc D Normandin; Georges El Fakhri; Nathaniel M Alpert Journal: Circ Cardiovasc Imaging Date: 2020-01-21 Impact factor: 7.792