Literature DB >> 23106212

Covalently linked tandem lesions in DNA.

Helen B Patrzyc1, Jean B Dawidzik, Edwin E Budzinski, Harold G Freund, John H Wilton, Harold C Box.   

Abstract

Reactive oxygen species (ROS) generate a type of DNA damage called tandem lesions, two adjacent nucleotides both modified. A subcategory of tandem lesions consists of adjacent nucleotides linked by a covalent bond. Covalently linked tandem lesions generate highly characteristic liquid chromotography-tandem mass spectrometry (LC-MS/MS) elution profiles. We have used this property to comprehensively survey X-irradiated DNA for covalently linked tandem lesions. A total of 15 tandem lesions were detected in DNA irradiated in deoxygenated aqueous solution, five tandem lesions were detected in DNA that was irradiated in oxygenated solution.

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Year:  2012        PMID： 23106212      PMCID： PMC3557944          DOI： 10.1667/RR2915.1

Source DB:  PubMed          Journal:  Radiat Res        ISSN： 0033-7587            Impact factor:   2.841


  18 in total

Review 1.  Free radical-induced double lesions in DNA.

Authors:  H C Box; J B Dawidzik; E E Budzinski
Journal:  Free Radic Biol Med       Date:  2001-10-01       Impact factor: 7.376

2.  Formation of intrastrand cross-link products between cytosine and adenine from UV irradiation of d((Br)CA) and duplex DNA containing a 5-bromocytosine.

Authors:  Haizheng Hong; Yinsheng Wang
Journal:  J Am Chem Soc       Date:  2005-10-12       Impact factor: 15.419

3.  Tandem lesions and other products in X-irradiated DNA oligomers.

Authors:  H C Box; E E Budzinski; J B Dawidzik; J C Wallace; H Iijima
Journal:  Radiat Res       Date:  1998-05       Impact factor: 2.841

4.  Guanine-thymine intrastrand cross-linked lesion containing oligonucleotides: from chemical synthesis to in vitro enzymatic replication.

Authors:  Sophie Bellon; Didier Gasparutto; Christine Saint-Pierre; Jean Cadet
Journal:  Org Biomol Chem       Date:  2006-09-19       Impact factor: 3.876

5.  Radiation-induced formation of a crosslink between base moieties of deoxyguanosine and thymidine in deoxygenated solutions of d(CpGpTpA).

Authors:  H C Box; E E Budzinski; J D Dawidzik; J C Wallace; M S Evans; J S Gobey
Journal:  Radiat Res       Date:  1996-05       Impact factor: 2.841

6.  Vicinal lesions in X-irradiated DNA?

Authors:  H C Box; E E Budzinski; H G Freund; M S Evans; H B Patrzyc; J C Wallace; A E MacCubbin
Journal:  Int J Radiat Biol       Date:  1993-09       Impact factor: 2.694

7.  Free radical-induced double base lesions.

Authors:  H C Box; H G Freund; E E Budzinski; J C Wallace; A E Maccubbin
Journal:  Radiat Res       Date:  1995-01       Impact factor: 2.841

8.  Mutation spectra induced by replication of two vicinal oxidative DNA lesions in mammalian cells.

Authors:  A Gentil; F Le Page; J Cadet; A Sarasin
Journal:  Mutat Res       Date:  2000-07-20       Impact factor: 2.433

9.  Recognition and incision of gamma-radiation-induced cross-linked guanine-thymine tandem lesion G[8,5-Me]T by UvrABC nuclease.

Authors:  Zhengguan Yang; Laureen C Colis; Ashis K Basu; Yue Zou
Journal:  Chem Res Toxicol       Date:  2005-09       Impact factor: 3.739

10.  In vivo formation and in vitro replication of a guanine-thymine intrastrand cross-link lesion.

Authors:  Yong Jiang; Haizheng Hong; Huachuan Cao; Yinsheng Wang
Journal:  Biochemistry       Date:  2007-10-12       Impact factor: 3.162
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  8 in total

1.  Traceless Tandem Lesion Formation in DNA from a Nitrogen-Centered Purine Radical.

Authors:  Liwei Zheng; Marc M Greenberg
Journal:  J Am Chem Soc       Date:  2018-05-08       Impact factor: 15.419

2.  Pyrimidine Nucleobase Radical Reactivity in DNA and RNA.

Authors:  Marc M Greenberg
Journal:  Radiat Phys Chem Oxf Engl 1993       Date:  2016-06-07       Impact factor: 2.858

3.  Reactivity of Nucleic Acid Radicals.

Authors:  Marc M Greenberg
Journal:  Adv Phys Org Chem       Date:  2016       Impact factor: 2.833

Review 4.  Formation and processing of DNA damage substrates for the hNEIL enzymes.

Authors:  Aaron M Fleming; Cynthia J Burrows
Journal:  Free Radic Biol Med       Date:  2016-11-20       Impact factor: 7.376

5.  DNA Damage Emanating From a Neutral Purine Radical Reveals the Sequence Dependent Convergence of the Direct and Indirect Effects of γ-Radiolysis.

Authors:  Liwei Zheng; Marc M Greenberg
Journal:  J Am Chem Soc       Date:  2017-11-30       Impact factor: 15.419

6.  Mutagenic Effects of a 2-Deoxyribonolactone-Thymine Glycol Tandem DNA Lesion in Human Cells.

Authors:  Spandana Naldiga; Haidong Huang; Marc M Greenberg; Ashis K Basu
Journal:  Biochemistry       Date:  2019-12-30       Impact factor: 3.162

7.  Mechanism studies of addition reactions between the pyrimidine type radicals and their 3'/5' neighboring deoxyguanosines.

Authors:  Shoushan Wang; Min Zhang; Peng Liu; Shilei Xie; Faliang Cheng; Lishi Wang
Journal:  RSC Adv       Date:  2018-01-12       Impact factor: 3.361

8.  5,6-Dihydropyrimidine peroxyl radical reactivity in DNA.

Authors:  Joanna Maria N San Pedro; Marc M Greenberg
Journal:  J Am Chem Soc       Date:  2014-02-28       Impact factor: 15.419
  8 in total

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