Literature DB >> 8619032

Radiation-induced formation of a crosslink between base moieties of deoxyguanosine and thymidine in deoxygenated solutions of d(CpGpTpA).

H C Box1, E E Budzinski, J D Dawidzik, J C Wallace, M S Evans, J S Gobey.   

Abstract

A new type of tandem base lesion has been observed in d(CpGpTpA) X-irradiated in aqueous solution. The lesion is attributed to the formation of a covalent bond between the C8 carbon atom of guanine and the methyl carbon atom of thymine. This tandem base lesion is formed in the absence of oxygen. It is the main product produced by ionizing radiation under these conditions.

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Year:  1996        PMID： 8619032

Source DB:  PubMed          Journal:  Radiat Res        ISSN： 0033-7587            Impact factor:   2.841


  25 in total

1.  Generation of guanine-thymidine cross-links in DNA by peroxynitrite/carbon dioxide.

Authors:  Byeong Hwa Yun; Nicholas E Geacintov; Vladimir Shafirovich
Journal:  Chem Res Toxicol       Date:  2011-05-04       Impact factor: 3.739

2.  Synthesis and thermodynamic studies of oligodeoxyribonucleotides containing tandem lesions of thymidine glycol and 8-oxo-2'-deoxyguanosine.

Authors:  Yuesong Wang; Yinsheng Wang
Journal:  Chem Res Toxicol       Date:  2006-06       Impact factor: 3.739

3.  Recognition and incision of oxidative intrastrand cross-link lesions by UvrABC nuclease.

Authors:  Chunang Gu; Qibin Zhang; Zhengguan Yang; Yuesong Wang; Yue Zou; Yinsheng Wang
Journal:  Biochemistry       Date:  2006-09-05       Impact factor: 3.162

4.  Intrastrand G-U cross-links generated by the oxidation of guanine in 5'-d(GCU) and 5'-r(GCU).

Authors:  Conor Crean; Nicholas E Geacintov; Vladimir Shafirovich
Journal:  Free Radic Biol Med       Date:  2008-07-23       Impact factor: 7.376

5.  Oxidatively Generated Guanine(C8)-Thymine(N3) Intrastrand Cross-links in Double-stranded DNA Are Repaired by Base Excision Repair Pathways.

Authors:  Ibtissam Talhaoui; Vladimir Shafirovich; Zhi Liu; Christine Saint-Pierre; Zhiger Akishev; Bakhyt T Matkarimov; Didier Gasparutto; Nicholas E Geacintov; Murat Saparbaev
Journal:  J Biol Chem       Date:  2015-04-22       Impact factor: 5.157

Review 6.  Removal of oxidatively generated DNA damage by overlapping repair pathways.

Authors:  Vladimir Shafirovich; Nicholas E Geacintov
Journal:  Free Radic Biol Med       Date:  2016-11-04       Impact factor: 7.376

7.  Generation of guanine-amino acid cross-links by a free radical combination mechanism.

Authors:  Yuriy Uvaydov; Nicholas E Geacintov; Vladimir Shafirovich
Journal:  Phys Chem Chem Phys       Date:  2014-05-09       Impact factor: 3.676

8.  Oxidative DNA damage induced by copper and hydrogen peroxide promotes CG-->TT tandem mutations at methylated CpG dinucleotides in nucleotide excision repair-deficient cells.

Authors:  Dong-Hyun Lee; Timothy R O'Connor; Gerd P Pfeifer
Journal:  Nucleic Acids Res       Date:  2002-08-15       Impact factor: 16.971

9.  Oxidation and reduction of the 5-(2'-deoxyuridinyl)methyl radical.

Authors:  Gengjie Lin; Lei Li
Journal:  Angew Chem Int Ed Engl       Date:  2013-04-15       Impact factor: 15.336

10.  Mutational specificity of gamma-radiation-induced guanine-thymine and thymine-guanine intrastrand cross-links in mammalian cells and translesion synthesis past the guanine-thymine lesion by human DNA polymerase eta.

Authors:  Laureen C Colis; Paromita Raychaudhury; Ashis K Basu
Journal:  Biochemistry       Date:  2008-07-11       Impact factor: 3.162
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