Literature DB >> 11585704

Free radical-induced double lesions in DNA.

H C Box1, J B Dawidzik, E E Budzinski.   

Abstract

This review surveys the work that has been done on free radical-induced DNA double lesions. Double lesions consist of two modifications of the DNA in close proximity. Double lesions can be generated by a single free radical-initiating event and the mechanism of formation often involves the participation of guanine. The identification of double lesions in oligomer and polymer DNA is reviewed and possible mechanisms of formation are outlined. The potential biological significance of double lesions is discussed. Double lesions induced by UV light are outside the scope of this review.

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Year:  2001        PMID： 11585704     DOI： 10.1016/s0891-5849(01)00653-0

Source DB:  PubMed          Journal:  Free Radic Biol Med        ISSN： 0891-5849            Impact factor:   7.376


  33 in total

1.  Generation of guanine-thymidine cross-links in DNA by peroxynitrite/carbon dioxide.

Authors:  Byeong Hwa Yun; Nicholas E Geacintov; Vladimir Shafirovich
Journal:  Chem Res Toxicol       Date:  2011-05-04       Impact factor: 3.739

2.  Backbone Flexibility Influences Nucleotide Incorporation by Human Translesion DNA Polymerase η opposite Intrastrand Cross-Linked DNA.

Authors:  Derek K O'Flaherty; F Peter Guengerich; Martin Egli; Christopher J Wilds
Journal:  Biochemistry       Date:  2015-12-16       Impact factor: 3.162

Review 3.  Clustered DNA lesion repair in eukaryotes: relevance to mutagenesis and cell survival.

Authors:  Evelyne Sage; Lynn Harrison
Journal:  Mutat Res       Date:  2010-12-24       Impact factor: 2.433

4.  Mechanism of DNA damage and apoptosis induced by tetrahydropapaveroline, a metabolite of dopamine.

Authors:  Hatasu Kobayashi; Shinji Oikawa; Shosuke Kawanishi
Journal:  Neurochem Res       Date:  2006-05-16       Impact factor: 3.996

5.  Recognition and incision of oxidative intrastrand cross-link lesions by UvrABC nuclease.

Authors:  Chunang Gu; Qibin Zhang; Zhengguan Yang; Yuesong Wang; Yue Zou; Yinsheng Wang
Journal:  Biochemistry       Date:  2006-09-05       Impact factor: 3.162

6.  Intrastrand G-U cross-links generated by the oxidation of guanine in 5'-d(GCU) and 5'-r(GCU).

Authors:  Conor Crean; Nicholas E Geacintov; Vladimir Shafirovich
Journal:  Free Radic Biol Med       Date:  2008-07-23       Impact factor: 7.376

7.  Oxidatively Generated Guanine(C8)-Thymine(N3) Intrastrand Cross-links in Double-stranded DNA Are Repaired by Base Excision Repair Pathways.

Authors:  Ibtissam Talhaoui; Vladimir Shafirovich; Zhi Liu; Christine Saint-Pierre; Zhiger Akishev; Bakhyt T Matkarimov; Didier Gasparutto; Nicholas E Geacintov; Murat Saparbaev
Journal:  J Biol Chem       Date:  2015-04-22       Impact factor: 5.157

8.  Generation of guanine-amino acid cross-links by a free radical combination mechanism.

Authors:  Yuriy Uvaydov; Nicholas E Geacintov; Vladimir Shafirovich
Journal:  Phys Chem Chem Phys       Date:  2014-05-09       Impact factor: 3.676

9.  Oxidation and reduction of the 5-(2'-deoxyuridinyl)methyl radical.

Authors:  Gengjie Lin; Lei Li
Journal:  Angew Chem Int Ed Engl       Date:  2013-04-15       Impact factor: 15.336

10.  Replication Past the γ-Radiation-Induced Guanine-Thymine Cross-Link G[8,5-Me]T by Human and Yeast DNA Polymerase η.

Authors:  Paromita Raychaudhury; Ashis K Basu
Journal:  J Nucleic Acids       Date:  2010-09-13
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