Literature DB >> 9588353

Tandem lesions and other products in X-irradiated DNA oligomers.

H C Box1, E E Budzinski, J B Dawidzik, J C Wallace, H Iijima.   

Abstract

Free radicals interact with DNA bases to produce secondary radicals. The secondary radicals are reactive species and tend to interact with neighboring bases, resulting in DNA lesions with two adjacent modified bases. In this study the DNA oligomers d(CpApTpG) and d(CpGpTpA) were exposed to free radicals generated in anoxic aqueous solution by X irradiation. Four new lesions were identified in which adjacent guanine and pyrimidine bases are covalently bonded. One of the tandem lesions formed in d(CpGpTpA) has the C5 carbon atom of cytosine covalently bonded to the C8 carbon atom of guanine. Interestingly, the same bond is formed between the terminal bases in d(CpApTpG), resulting in a cyclized molecule.

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Year:  1998        PMID： 9588353

Source DB:  PubMed          Journal:  Radiat Res        ISSN： 0033-7587            Impact factor:   2.841


  28 in total

Review 1.  DNA damage by reactive species: Mechanisms, mutation and repair.

Authors:  N R Jena
Journal:  J Biosci       Date:  2012-07       Impact factor: 1.826

2.  Closely opposed apurinic/apyrimidinic sites are converted to double strand breaks in Escherichia coli even in the absence of exonuclease III, endonuclease IV, nucleotide excision repair and AP lyase cleavage.

Authors:  Lynn Harrison; Katherine L Brame; Laura E Geltz; April M Landry
Journal:  DNA Repair (Amst)       Date:  2005-12-06

3.  Recognition and incision of oxidative intrastrand cross-link lesions by UvrABC nuclease.

Authors:  Chunang Gu; Qibin Zhang; Zhengguan Yang; Yuesong Wang; Yue Zou; Yinsheng Wang
Journal:  Biochemistry       Date:  2006-09-05       Impact factor: 3.162

4.  Intrastrand G-U cross-links generated by the oxidation of guanine in 5'-d(GCU) and 5'-r(GCU).

Authors:  Conor Crean; Nicholas E Geacintov; Vladimir Shafirovich
Journal:  Free Radic Biol Med       Date:  2008-07-23       Impact factor: 7.376

Review 5.  An overview of chemical processes that damage cellular DNA: spontaneous hydrolysis, alkylation, and reactions with radicals.

Authors:  Kent S Gates
Journal:  Chem Res Toxicol       Date:  2009-11       Impact factor: 3.739

6.  Pyrimidine Nucleobase Radical Reactivity in DNA and RNA.

Authors:  Marc M Greenberg
Journal:  Radiat Phys Chem Oxf Engl 1993       Date:  2016-06-07       Impact factor: 2.858

Review 7.  Occurrence, Biological Consequences, and Human Health Relevance of Oxidative Stress-Induced DNA Damage.

Authors:  Yang Yu; Yuxiang Cui; Laura J Niedernhofer; Yinsheng Wang
Journal:  Chem Res Toxicol       Date:  2016-11-07       Impact factor: 3.739

8.  Oxidative DNA damage induced by copper and hydrogen peroxide promotes CG-->TT tandem mutations at methylated CpG dinucleotides in nucleotide excision repair-deficient cells.

Authors:  Dong-Hyun Lee; Timothy R O'Connor; Gerd P Pfeifer
Journal:  Nucleic Acids Res       Date:  2002-08-15       Impact factor: 16.971

9.  Efficient formation of the tandem thymine glycol/8-oxo-7,8-dihydroguanine lesion in isolated DNA and the mutagenic and cytotoxic properties of the tandem lesions in Escherichia coli cells.

Authors:  Bifeng Yuan; Yong Jiang; Yuesong Wang; Yinsheng Wang
Journal:  Chem Res Toxicol       Date:  2010-01       Impact factor: 3.739

10.  Mutational specificity of gamma-radiation-induced guanine-thymine and thymine-guanine intrastrand cross-links in mammalian cells and translesion synthesis past the guanine-thymine lesion by human DNA polymerase eta.

Authors:  Laureen C Colis; Paromita Raychaudhury; Ashis K Basu
Journal:  Biochemistry       Date:  2008-07-11       Impact factor: 3.162
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