| Literature DB >> 21737267 |
Tyler L Harris1, Roberta J Worthington, Christian Melander.
Abstract
An efficient synthetic route to 1,5-disubstituted 2-aminoimidazoles from readily available amino acids and aldehydes has been developed. A library of simple analogues was synthesized and several compounds were shown to exhibit notable antibiotic activity against a variety of bacterial strains including multi-drug resistant isolates.Entities:
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Year: 2011 PMID： 21737267 DOI： 10.1016/j.bmcl.2011.05.123
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823