BACKGROUND: Blood omega-3 and omega-6 fatty acid levels have been associated with reduced risk for total mortality in patients with stable coronary heart disease (CHD), but their relationships with mortality in the setting of myocardial infarction (MI) are unknown. OBJECTIVE: To determine the association between red blood cell (RBC) fatty acid levels measured at admission and 2-year mortality in MI patients, independent of the GRACE risk score, a traditional mode of risk stratification. DESIGN: Admission RBC fatty acid levels were measured in patients enrolled in a prospective, 24-center MI registry (TRIUMPH). Two-year mortality was modeled with Cox proportional hazards regression to assess the extent to which the inclusion of fatty acid levels would improve, over and above the GRACE score, risk stratification for 2-year mortality. RESULTS: RBC fatty acid data were available from 1144 patients who did not report taking fish oil supplements after discharge. Two RBC fatty acids [eicosapentaenoic acid (EPA) and docosapentaenoic n-6 (DPA)] were univariate predictors of total mortality. The combined fatty acid c-statistic (0.60, p<0.001) improved the c-statistic of the GRACE score alone from 0.747 (p<0.001) to 0.768 (p<0.05 vs. GRACE alone). The net reclassification index improved by 31% (95% CI, 15% to 48%) and the relative incremental discrimination index improved by 19.8% (7.5% to 35.7%). CONCLUSION: RBC EPA and DPA n-6 levels improved the prediction of 2-yr mortality over and above the GRACE score in MI patients.
BACKGROUND: Blood omega-3 and omega-6 fatty acid levels have been associated with reduced risk for total mortality in patients with stable coronary heart disease (CHD), but their relationships with mortality in the setting of myocardial infarction (MI) are unknown. OBJECTIVE: To determine the association between red blood cell (RBC) fatty acid levels measured at admission and 2-year mortality in MI patients, independent of the GRACE risk score, a traditional mode of risk stratification. DESIGN: Admission RBC fatty acid levels were measured in patients enrolled in a prospective, 24-center MI registry (TRIUMPH). Two-year mortality was modeled with Cox proportional hazards regression to assess the extent to which the inclusion of fatty acid levels would improve, over and above the GRACE score, risk stratification for 2-year mortality. RESULTS: RBC fatty acid data were available from 1144 patients who did not report taking fish oil supplements after discharge. Two RBC fatty acids [eicosapentaenoic acid (EPA) and docosapentaenoic n-6 (DPA)] were univariate predictors of total mortality. The combined fatty acid c-statistic (0.60, p<0.001) improved the c-statistic of the GRACE score alone from 0.747 (p<0.001) to 0.768 (p<0.05 vs. GRACE alone). The net reclassification index improved by 31% (95% CI, 15% to 48%) and the relative incremental discrimination index improved by 19.8% (7.5% to 35.7%). CONCLUSION: RBC EPA and DPA n-6 levels improved the prediction of 2-yr mortality over and above the GRACE score in MI patients.
Authors: Ramin Farzaneh-Far; Jue Lin; Elissa S Epel; William S Harris; Elizabeth H Blackburn; Mary A Whooley Journal: JAMA Date: 2010-01-20 Impact factor: 56.272
Authors: Robert G Metcalf; Leslie G Cleland; Robert A Gibson; Kurt C Roberts-Thomson; James Rm Edwards; Prashanthan Sanders; Robert Stuklis; Michael J James; Glenn D Young Journal: Am J Clin Nutr Date: 2010-01-20 Impact factor: 7.045
Authors: Hildegunn Aarsetoey; Volker Pönitz; Heidi Grundt; Harry Staines; William S Harris; Dennis W T Nilsen Journal: J Nutr Date: 2009-01-21 Impact factor: 4.798
Authors: Ana Teresa Timóteo; Alexandra Toste; Ruben Ramos; Fernando Miranda; Maria Lurdes Ferreira; José Alberto Oliveira; Rui Cruz Ferreira Journal: Acute Card Care Date: 2009
Authors: Reheman Adili; Ellen M Voigt; Jordan L Bormann; Kaitlynn N Foss; Luke J Hurley; Evan S Meyer; Amber J Veldman; Katherine A Mast; Joshua L West; Sidney W Whiteheart; Michael Holinstat; Mark K Larson Journal: Platelets Date: 2017-12-29 Impact factor: 3.862
Authors: William S Harris; Juhua Luo; James V Pottala; Mark A Espeland; Karen L Margolis; Joann E Manson; Lu Wang; Theodore M Brasky; Jennifer G Robinson Journal: J Clin Lipidol Date: 2017-01-12 Impact factor: 4.766
Authors: Ashley M Eskew; Kelly C Wormer; Michelle L Matthews; H James Norton; Margaret A Papadakis; Bradley S Hurst Journal: J Assist Reprod Genet Date: 2017-09-13 Impact factor: 3.412
Authors: Eric B Rimm; Lawrence J Appel; Stephanie E Chiuve; Luc Djoussé; Mary B Engler; Penny M Kris-Etherton; Dariush Mozaffarian; David S Siscovick; Alice H Lichtenstein Journal: Circulation Date: 2018-05-17 Impact factor: 29.690