Literature DB >> 22948865

Regulation of RamA by RamR in Salmonella enterica serovar Typhimurium: isolation of a RamR superrepressor.

Vito Ricci1, Stephen J W Busby, Laura J V Piddock.   

Abstract

RamA is a transcription factor involved in regulating multidrug resistance in Salmonella enterica serovar Typhimurium SL1344. Green fluorescent protein (GFP) reporter fusions were exploited to investigate the regulation of RamA expression by RamR. We show that RamR represses the ramA promoter by binding to a palindromic sequence and describe a superrepressor RamR mutant that binds to the ramA promoter sequence more efficiently, thus exhibiting a ramA inactivated phenotype.

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Year:  2012        PMID： 22948865      PMCID： PMC3486581          DOI： 10.1128/AAC.01320-12

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  14 in total

1.  Structural basis for cooperative DNA binding by two dimers of the multidrug-binding protein QacR.

Authors:  Maria A Schumacher; Marshall C Miller; Steve Grkovic; Melissa H Brown; Ronald A Skurray; Richard G Brennan
Journal:  EMBO J       Date:  2002-03-01       Impact factor: 11.598

2.  Identification of host-induced pathogen genes by differential fluorescence induction reporter systems.

Authors:  Dirk Bumann; Raphael H Valdivia
Journal:  Nat Protoc       Date:  2007       Impact factor: 13.491

3.  Crystal structure of the transcriptional regulator AcrR from Escherichia coli.

Authors:  Ming Li; Ruoyu Gu; Chih-Chia Su; Mathew D Routh; Katherine C Harris; Elizabeth S Jewell; Gerry McDermott; Edward W Yu
Journal:  J Mol Biol       Date:  2007-09-29       Impact factor: 5.469

4.  Effect of transcriptional activators RamA and SoxS on expression of multidrug efflux pumps AcrAB and AcrEF in fluoroquinolone-resistant Salmonella Typhimurium.

Authors:  Jie Zheng; Shenghui Cui; Jianghong Meng
Journal:  J Antimicrob Chemother       Date:  2008-11-04       Impact factor: 5.790

5.  Ciprofloxacin selects for multidrug resistance in Salmonella enterica serovar Typhimurium mediated by at least two different pathways.

Authors:  Vito Ricci; Laura J V Piddock
Journal:  J Antimicrob Chemother       Date:  2009-03-06       Impact factor: 5.790

6.  ramR mutations involved in efflux-mediated multidrug resistance in Salmonella enterica serovar Typhimurium.

Authors:  Yousef M Abouzeed; Sylvie Baucheron; Axel Cloeckaert
Journal:  Antimicrob Agents Chemother       Date:  2008-04-28       Impact factor: 5.191

Review 7.  Structures of AcrR and CmeR: insight into the mechanisms of transcriptional repression and multi-drug recognition in the TetR family of regulators.

Authors:  Mathew D Routh; Chih-Chia Su; Qijing Zhang; Edward W Yu
Journal:  Biochim Biophys Acta       Date:  2008-12-14

8.  Salmonella gene rma (ramA) and multiple-drug-resistant Salmonella enterica serovar typhimurium.

Authors:  Tahar van der Straaten; Riny Janssen; Dik J Mevius; Jaap T van Dissel
Journal:  Antimicrob Agents Chemother       Date:  2004-06       Impact factor: 5.191

9.  The TCA cycle is not required for selection or survival of multidrug-resistant Salmonella.

Authors:  Vito Ricci; Nick Loman; Mark Pallen; Alasdair Ivens; Maria Fookes; Gemma C Langridge; John Wain; Laura J V Piddock
Journal:  J Antimicrob Chemother       Date:  2011-12-20       Impact factor: 5.790

10.  AcrAB multidrug efflux pump regulation in Salmonella enterica serovar Typhimurium by RamA in response to environmental signals.

Authors:  Eiji Nikaido; Akihito Yamaguchi; Kunihiko Nishino
Journal:  J Biol Chem       Date:  2008-06-24       Impact factor: 5.157
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  9 in total

1.  MarA, SoxS and Rob of Escherichia coli - Global regulators of multidrug resistance, virulence and stress response.

Authors:  Valérie Duval; Ida M Lister
Journal:  Int J Biotechnol Wellness Ind       Date:  2013

Review 2.  RND-type drug efflux pumps from Gram-negative bacteria: molecular mechanism and inhibition.

Authors:  Henrietta Venter; Rumana Mowla; Thelma Ohene-Agyei; Shutao Ma
Journal:  Front Microbiol       Date:  2015-04-28       Impact factor: 5.640

3.  Computational Analysis of the Molecular Mechanism of RamR Mutations Contributing to Antimicrobial Resistance in Salmonella enterica.

Authors:  Yen-Yi Liu; Chih-Chieh Chen
Journal:  Sci Rep       Date:  2017-10-17       Impact factor: 4.379

4.  CsrA maximizes expression of the AcrAB multidrug resistance transporter.

Authors:  Vito Ricci; Victoria Attah; Tim Overton; David C Grainger; Laura J V Piddock
Journal:  Nucleic Acids Res       Date:  2017-12-15       Impact factor: 16.971

5.  New Multidrug Efflux Inhibitors for Gram-Negative Bacteria.

Authors:  Robert L Marshall; Georgina S Lloyd; Amelia J Lawler; Sarah J Element; Jaswant Kaur; Maria Laura Ciusa; Vito Ricci; Andreas Tschumi; Holger Kühne; Luke J Alderwick; Laura J V Piddock
Journal:  mBio       Date:  2020-07-14       Impact factor: 7.867

6.  TetR-family transcription factors in Gram-negative bacteria: conservation, variation and implications for efflux-mediated antimicrobial resistance.

Authors:  A L Colclough; J Scadden; J M A Blair
Journal:  BMC Genomics       Date:  2019-10-12       Impact factor: 3.969

7.  Reduced Efflux Pumps Expression of Pseudomonas Aeruginosa with Satureja Khuzistanica Essential Oil.

Authors:  Davoud Iman Islamieh; Hossein Goudarzi; Azad Khaledi; Davoud Afshar; Davoud Esmaeili
Journal:  Iran J Med Sci       Date:  2020-11

8.  Genetic inactivation of acrAB or inhibition of efflux induces expression of ramA.

Authors:  A J Lawler; V Ricci; S J W Busby; L J V Piddock
Journal:  J Antimicrob Chemother       Date:  2013-03-14       Impact factor: 5.790

9.  RamA, which controls expression of the MDR efflux pump AcrAB-TolC, is regulated by the Lon protease.

Authors:  Vito Ricci; Jessica M A Blair; Laura J V Piddock
Journal:  J Antimicrob Chemother       Date:  2013-10-29       Impact factor: 5.790
  9 in total

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