Literature DB >> 15155237

Salmonella gene rma (ramA) and multiple-drug-resistant Salmonella enterica serovar typhimurium.

Tahar van der Straaten1, Riny Janssen, Dik J Mevius, Jaap T van Dissel.   

Abstract

MarA and its homologue, RamA, have been implicated in multidrug resistance (MDR). RamA overexpression in Salmonella enterica serovar Typhimurium and Escherichia coli conferred MDR independently of marA. Inactivation of ramA did not affect the antibiotic susceptibilities of wild-type S. enterica serovar Typhimurium or 15 unrelated clinical MDR isolates. Thus, ramA overexpression is not a common MDR mechanism in Salmonella.

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Year:  2004        PMID： 15155237      PMCID： PMC415616          DOI： 10.1128/AAC.48.6.2292-2294.2004

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  9 in total

1.  Bacterial resistance: origins, epidemiology, and impact.

Authors:  David M Livermore
Journal:  Clin Infect Dis       Date:  2003-01-15       Impact factor: 9.079

Review 2.  Regulation of chromosomally mediated multiple antibiotic resistance: the mar regulon.

Authors:  M N Alekshun; S B Levy
Journal:  Antimicrob Agents Chemother       Date:  1997-10       Impact factor: 5.191

3.  Transcriptional activation of promoters of the superoxide and multiple antibiotic resistance regulons by Rob, a binding protein of the Escherichia coli origin of chromosomal replication.

Authors:  K W Jair; X Yu; K Skarstad; B Thöny; N Fujita; A Ishihama; R E Wolf
Journal:  J Bacteriol       Date:  1996-05       Impact factor: 3.490

4.  Molecular cloning and characterization of the Salmonella enterica Serovar Paratyphi B rma Gene, which confers multiple drug resistance in Escherichia coli.

Authors:  Mahmoud A Yassien; Hosam E Ewis; Chung-Dar Lu; Ahmed T Abdelal
Journal:  Antimicrob Agents Chemother       Date:  2002-02       Impact factor: 5.191

5.  The Salmonella typhimurium mar locus: molecular and genetic analyses and assessment of its role in virulence.

Authors:  M C Sulavik; M Dazer; P F Miller
Journal:  J Bacteriol       Date:  1997-03       Impact factor: 3.490

6.  Identification for mar mutants among quinolone-resistant clinical isolates of Escherichia coli.

Authors:  K Maneewannakul; S B Levy
Journal:  Antimicrob Agents Chemother       Date:  1996-07       Impact factor: 5.191

7.  Multidrug resistance in Klebsiella pneumoniae: a novel gene, ramA, confers a multidrug resistance phenotype in Escherichia coli.

Authors:  Anthony M George; Ruth M Hall; H W Stokes
Journal:  Microbiology (Reading)       Date:  1995-08       Impact factor: 2.777

8.  Overexpression of the marA or soxS regulatory gene in clinical topoisomerase mutants of Escherichia coli.

Authors:  M Oethinger; I Podglajen; W V Kern; S B Levy
Journal:  Antimicrob Agents Chemother       Date:  1998-08       Impact factor: 5.191

9.  Salmonella enterica serovar Typhimurium RamA, intracellular oxidative stress response, and bacterial virulence.

Authors:  Tahar van der Straaten; Laurence Zulianello; Angela van Diepen; Donald L Granger; Riny Janssen; Jaap T van Dissel
Journal:  Infect Immun       Date:  2004-02       Impact factor: 3.441
  9 in total
  17 in total

Review 1.  Clinically relevant chromosomally encoded multidrug resistance efflux pumps in bacteria.

Authors:  Laura J V Piddock
Journal:  Clin Microbiol Rev       Date:  2006-04       Impact factor: 26.132

Review 2.  Efflux-mediated drug resistance in bacteria: an update.

Authors:  Xian-Zhi Li; Hiroshi Nikaido
Journal:  Drugs       Date:  2009-08-20       Impact factor: 9.546

Review 3.  Molecular mechanisms of antibiotic resistance.

Authors:  Jessica M A Blair; Mark A Webber; Alison J Baylay; David O Ogbolu; Laura J V Piddock
Journal:  Nat Rev Microbiol       Date:  2014-12-01       Impact factor: 60.633

4.  Regulation of RamA by RamR in Salmonella enterica serovar Typhimurium: isolation of a RamR superrepressor.

Authors:  Vito Ricci; Stephen J W Busby; Laura J V Piddock
Journal:  Antimicrob Agents Chemother       Date:  2012-09-04       Impact factor: 5.191

5.  Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials.

Authors:  Sheng Chen; Shenghui Cui; Patrick F McDermott; Shaohua Zhao; David G White; Ian Paulsen; Jianghong Meng
Journal:  Antimicrob Agents Chemother       Date:  2006-10-16       Impact factor: 5.191

Review 6.  Tetracycline Antibiotics and Resistance.

Authors:  Trudy H Grossman
Journal:  Cold Spring Harb Perspect Med       Date:  2016-04-01       Impact factor: 6.915

7.  AcrB drug-binding pocket substitution confers clinically relevant resistance and altered substrate specificity.

Authors:  Jessica M A Blair; Vassiliy N Bavro; Vito Ricci; Niraj Modi; Pierpaolo Cacciotto; Ulrich Kleinekathӧfer; Paolo Ruggerone; Attilio V Vargiu; Alison J Baylay; Helen E Smith; Yvonne Brandon; David Galloway; Laura J V Piddock
Journal:  Proc Natl Acad Sci U S A       Date:  2015-03-03       Impact factor: 11.205

8.  RamA, a member of the AraC/XylS family, influences both virulence and efflux in Salmonella enterica serovar Typhimurium.

Authors:  Andrew M Bailey; Al Ivens; Rob Kingsley; Jennifer L Cottell; John Wain; Laura J V Piddock
Journal:  J Bacteriol       Date:  2010-01-15       Impact factor: 3.490

9.  RamA confers multidrug resistance in Salmonella enterica via increased expression of acrB, which is inhibited by chlorpromazine.

Authors:  Andrew M Bailey; Ian T Paulsen; Laura J V Piddock
Journal:  Antimicrob Agents Chemother       Date:  2008-08-11       Impact factor: 5.191

10.  ramR mutations involved in efflux-mediated multidrug resistance in Salmonella enterica serovar Typhimurium.

Authors:  Yousef M Abouzeed; Sylvie Baucheron; Axel Cloeckaert
Journal:  Antimicrob Agents Chemother       Date:  2008-04-28       Impact factor: 5.191
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