Literature DB >> 22815232

The mechanism of eukaryotic translation initiation: new insights and challenges.

Alan G Hinnebusch1, Jon R Lorsch.   

Abstract

Translation initiation in eukaryotes is a highly regulated and complex stage of gene expression. It requires the action of at least 12 initiation factors, many of which are known to be the targets of regulatory pathways. Here we review our current understanding of the molecular mechanics of eukaryotic translation initiation, focusing on recent breakthroughs from in vitro and in vivo studies. We also identify important unanswered questions that will require new ideas and techniques to solve.

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Year:  2012        PMID： 22815232      PMCID： PMC3475172          DOI： 10.1101/cshperspect.a011544

Source DB:  PubMed          Journal:  Cold Spring Harb Perspect Biol        ISSN： 1943-0264            Impact factor:   9.708


  131 in total

1.  The requirement for eukaryotic initiation factor 4A (elF4A) in translation is in direct proportion to the degree of mRNA 5' secondary structure.

Authors:  Y V Svitkin; A Pause; A Haghighat; S Pyronnet; G Witherell; G J Belsham; N Sonenberg
Journal:  RNA       Date:  2001-03       Impact factor: 4.942

Review 2.  Molecular view of 43 S complex formation and start site selection in eukaryotic translation initiation.

Authors:  Jon R Lorsch; Thomas E Dever
Journal:  J Biol Chem       Date:  2010-05-05       Impact factor: 5.157

3.  Phosphorylation of plant translation initiation factors by CK2 enhances the in vitro interaction of multifactor complex components.

Authors:  Michael D Dennis; Maria D Person; Karen S Browning
Journal:  J Biol Chem       Date:  2009-06-09       Impact factor: 5.157

4.  Intrinsic RNA binding by the eukaryotic initiation factor 4F depends on a minimal RNA length but not on the m7G cap.

Authors:  Nicholas M Kaye; Kelly J Emmett; William C Merrick; Eckhard Jankowsky
Journal:  J Biol Chem       Date:  2009-05-04       Impact factor: 5.157

5.  The helicase protein DHX29 promotes translation initiation, cell proliferation, and tumorigenesis.

Authors:  Armen Parsyan; David Shahbazian; Yvan Martineau; Emmanuel Petroulakis; Tommy Alain; Ola Larsson; Geraldine Mathonnet; Gritta Tettweiler; Christopher U Hellen; Tatyana V Pestova; Yuri V Svitkin; Nahum Sonenberg
Journal:  Proc Natl Acad Sci U S A       Date:  2009-12-11       Impact factor: 11.205

6.  Initiation factor eIF5B catalyzes second GTP-dependent step in eukaryotic translation initiation.

Authors:  Joon H Lee; Tatyana V Pestova; Byung-Sik Shin; Chune Cao; Sang K Choi; Thomas E Dever
Journal:  Proc Natl Acad Sci U S A       Date:  2002-12-06       Impact factor: 11.205

7.  Eukaryotic translation initiation factor 3 (eIF3) and eIF2 can promote mRNA binding to 40S subunits independently of eIF4G in yeast.

Authors:  Antonina V Jivotovskaya; Leos Valásek; Alan G Hinnebusch; Klaus H Nielsen
Journal:  Mol Cell Biol       Date:  2006-02       Impact factor: 4.272

8.  Specific functional interactions of nucleotides at key -3 and +4 positions flanking the initiation codon with components of the mammalian 48S translation initiation complex.

Authors:  Andrey V Pisarev; Victoria G Kolupaeva; Vera P Pisareva; William C Merrick; Christopher U T Hellen; Tatyana V Pestova
Journal:  Genes Dev       Date:  2006-03-01       Impact factor: 11.361

9.  The structure of the eukaryotic ribosome at 3.0 Å resolution.

Authors:  Adam Ben-Shem; Nicolas Garreau de Loubresse; Sergey Melnikov; Lasse Jenner; Gulnara Yusupova; Marat Yusupov
Journal:  Science       Date:  2011-11-17       Impact factor: 47.728

10.  The universal YrdC/Sua5 family is required for the formation of threonylcarbamoyladenosine in tRNA.

Authors:  Basma El Yacoubi; Benjamin Lyons; Yulien Cruz; Robert Reddy; Brian Nordin; Fabio Agnelli; James R Williamson; Paul Schimmel; Manal A Swairjo; Valérie de Crécy-Lagard
Journal:  Nucleic Acids Res       Date:  2009-03-13       Impact factor: 16.971
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  213 in total

1.  Emerging therapeutics targeting mRNA translation.

Authors:  Abba Malina; John R Mills; Jerry Pelletier
Journal:  Cold Spring Harb Perspect Biol       Date:  2012-04-01       Impact factor: 10.005

Review 2.  The molecular mechanism of translational control via the communication between the microRNA pathway and RNA-binding proteins.

Authors:  Akira Fukao; Tomohiko Aoyama; Toshinobu Fujiwara
Journal:  RNA Biol       Date:  2015       Impact factor: 4.652

Review 3.  Eukaryote-specific extensions in ribosomal proteins of the small subunit: Structure and function.

Authors:  Arnab Ghosh; Anton A Komar
Journal:  Translation (Austin)       Date:  2015-02-05

4.  β-Hairpin loop of eukaryotic initiation factor 1 (eIF1) mediates 40 S ribosome binding to regulate initiator tRNA(Met) recruitment and accuracy of AUG selection in vivo.

Authors:  Pilar Martin-Marcos; Jagpreet Nanda; Rafael E Luna; Gerhard Wagner; Jon R Lorsch; Alan G Hinnebusch
Journal:  J Biol Chem       Date:  2013-07-26       Impact factor: 5.157

5.  Translational Regulation of Cytoplasmic mRNAs.

Authors:  Bijoyita Roy; Albrecht G von Arnim
Journal:  Arabidopsis Book       Date:  2013-07-18

6.  Dom34 rescues ribosomes in 3' untranslated regions.

Authors:  Nicholas R Guydosh; Rachel Green
Journal:  Cell       Date:  2014-02-27       Impact factor: 41.582

7.  Identification and characterization of functionally critical, conserved motifs in the internal repeats and N-terminal domain of yeast translation initiation factor 4B (yeIF4B).

Authors:  Fujun Zhou; Sarah E Walker; Sarah F Mitchell; Jon R Lorsch; Alan G Hinnebusch
Journal:  J Biol Chem       Date:  2013-11-27       Impact factor: 5.157

8.  Human eukaryotic initiation factor 4G (eIF4G) protein binds to eIF3c, -d, and -e to promote mRNA recruitment to the ribosome.

Authors:  Nancy Villa; Angelie Do; John W B Hershey; Christopher S Fraser
Journal:  J Biol Chem       Date:  2013-10-03       Impact factor: 5.157

9.  Leucine supplementation stimulates protein synthesis and reduces degradation signal activation in muscle of newborn pigs during acute endotoxemia.

Authors:  Adriana D Hernandez-García; Daniel A Columbus; Rodrigo Manjarín; Hanh V Nguyen; Agus Suryawan; Renán A Orellana; Teresa A Davis
Journal:  Am J Physiol Endocrinol Metab       Date:  2016-09-13       Impact factor: 4.310

Review 10.  Ribosome-based quality control of mRNA and nascent peptides.

Authors:  Carrie L Simms; Erica N Thomas; Hani S Zaher
Journal:  Wiley Interdiscip Rev RNA       Date:  2016-05-18       Impact factor: 9.957
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