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Literature DB >> 22689470

Cyclic caged morpholinos: conformationally gated probes of embryonic gene function.

Sayumi Yamazoe¹, Ilya A Shestopalov, Elayne Provost, Steven D Leach, James K Chen.

Abstract

Feeling a bit cagey: morpholino-based antisense reagents have been caged through oligonucleotide cyclization, enabling photocontrol of gene expression in zebrafish embryos and larvae. Using these reagents, the timing of exocrine cell fate commitment in the developing pancreas has been examined.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2012 PMID： 22689470 PMCID： PMC3434341 DOI： 10.1002/anie.201201690

Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336

21 in total

1. Energetic coupling between DNA bending and base pair opening.

Authors: J Ramstein; R Lavery
Journal: Proc Natl Acad Sci U S A Date: 1988-10 Impact factor: 11.205

Review 2. Morpholino antisense oligomers: design, preparation, and properties.

Authors: J Summerton; D Weller
Journal: Antisense Nucleic Acid Drug Dev Date: 1997-06

3. Induction of muscle pioneers and floor plate is distinguished by the zebrafish no tail mutation.

Authors: M E Halpern; R K Ho; C Walker; C B Kimmel
Journal: Cell Date: 1993-10-08 Impact factor: 41.582

4. Beta-catenin signaling activity dissected in the early Xenopus embryo: a novel antisense approach.

Authors: J Heasman; M Kofron; C Wylie
Journal: Dev Biol Date: 2000-06-01 Impact factor: 3.582

5. Effective targeted gene 'knockdown' in zebrafish.

Authors: A Nasevicius; S C Ekker
Journal: Nat Genet Date: 2000-10 Impact factor: 38.330

6. Differential requirement for ptf1a in endocrine and exocrine lineages of developing zebrafish pancreas.

Authors: John W Lin; Andrew V Biankin; Marko E Horb; Bidyut Ghosh; Nijaguna B Prasad; Nelson S Yee; Michael A Pack; Steven D Leach
Journal: Dev Biol Date: 2004-06-15 Impact factor: 3.582

7. The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors.

Authors: Yoshiya Kawaguchi; Bonnie Cooper; Maureen Gannon; Michael Ray; Raymond J MacDonald; Christopher V E Wright
Journal: Nat Genet Date: 2002-08-19 Impact factor: 38.330

8. Evolutionary conserved role of ptf1a in the specification of exocrine pancreatic fates.

Authors: Elisabetta Zecchin; Anastasia Mavropoulos; Nathalie Devos; Alida Filippi; Natascia Tiso; Dirk Meyer; Bernard Peers; Marino Bortolussi; Francesco Argenton
Journal: Dev Biol Date: 2004-04-01 Impact factor: 3.582

9. no tail (ntl) is the zebrafish homologue of the mouse T (Brachyury) gene.

Authors: S Schulte-Merker; F J van Eeden; M E Halpern; C B Kimmel; C Nüsslein-Volhard
Journal: Development Date: 1994-04 Impact factor: 6.868

10. The protein product of the zebrafish homologue of the mouse T gene is expressed in nuclei of the germ ring and the notochord of the early embryo.

Authors: S Schulte-Merker; R K Ho; B G Herrmann; C Nüsslein-Volhard
Journal: Development Date: 1992-12 Impact factor: 6.868

30 in total

Cyclic caged morpholinos: conformationally gated probes of embryonic gene function.

1. Energetic coupling between DNA bending and base pair opening.

Review 2. Morpholino antisense oligomers: design, preparation, and properties.

3. Induction of muscle pioneers and floor plate is distinguished by the zebrafish no tail mutation.

4. Beta-catenin signaling activity dissected in the early Xenopus embryo: a novel antisense approach.

5. Effective targeted gene 'knockdown' in zebrafish.

6. Differential requirement for ptf1a in endocrine and exocrine lineages of developing zebrafish pancreas.

7. The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors.

8. Evolutionary conserved role of ptf1a in the specification of exocrine pancreatic fates.

9. no tail (ntl) is the zebrafish homologue of the mouse T (Brachyury) gene.

10. The protein product of the zebrafish homologue of the mouse T gene is expressed in nuclei of the germ ring and the notochord of the early embryo.

Review 1. Optochemical Control of Biological Processes in Cells and Animals.

2. Illuminating developmental biology through photochemistry.

3. Optochemical dissection of T-box gene-dependent medial floor plate development.

4. Visible-to-NIR-Light Activated Release: From Small Molecules to Nanomaterials.

Review 5. Caged oligonucleotides for studying biological systems.

6. Sequential gene silencing using wavelength-selective caged morpholino oligonucleotides.

7. Combinatorial control of gene function with wavelength-selective caged morpholinos.

8. Optochemical control of deoxyoligonucleotide function via a nucleobase-caging approach.

9. Caged oligonucleotides for bidirectional photomodulation of let-7 miRNA in zebrafish embryos.

10. Efficient Synthesis of Light-Triggered Circular Antisense Oligonucleotides Targeting Cellular Protein Expression.