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Literature DB >> 22647267

Global heterochromatin loss: a unifying theory of aging?

Abstract

The aging field is replete with theories. Over the past years, many distinct, yet overlapping mechanisms have been proposed to explain organismal aging. These include free radicals, loss of heterochromatin, genetically programmed senescence, telomere shortening, genomic instability, nutritional intake and growth signaling, to name a few. The objective of this Point-of-View is to highlight recent progress on the "loss of heterochromatin" model of aging and to propose that epigenetic changes contributing to global heterochromatin loss may underlie the various cellular processes associated with aging.

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Year: 2012 PMID： 22647267 PMCID： PMC3414389 DOI： 10.4161/epi.20540

Source DB: PubMed Journal: Epigenetics ISSN： 1559-2294 Impact factor: 4.528

152 in total

1. Global DNA methylation in old subjects is correlated with frailty.

Authors: Dina Bellizzi; Patrizia D'Aquila; Alberto Montesanto; Andrea Corsonello; Vincenzo Mari; Bruno Mazzei; Fabrizia Lattanzio; Giuseppe Passarino
Journal: Age (Dordr) Date: 2011-02-19

2. A damage limitation exercise.

Authors: Andrejs Ivanov; Peter D Adams
Journal: Nat Cell Biol Date: 2011-03 Impact factor: 28.824

3. SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities.

Authors: Lirong Peng; Zhigang Yuan; Hongbo Ling; Kenji Fukasawa; Keith Robertson; Nancy Olashaw; John Koomen; Jiandong Chen; William S Lane; Edward Seto
Journal: Mol Cell Biol Date: 2011-09-26 Impact factor: 4.272

4. Caloric restriction attenuates age-related changes of DNA methyltransferase 3a in mouse hippocampus.

Authors: L Chouliaras; D L A van den Hove; G Kenis; J Dela Cruz; M A M Lemmens; J van Os; H W M Steinbusch; C Schmitz; B P F Rutten
Journal: Brain Behav Immun Date: 2010-12-21 Impact factor: 7.217

5. Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type- and insult-dependent manner and follow expression of p16(ink4a).

Authors: Martin Kosar; Jirina Bartkova; Sona Hubackova; Zdenek Hodny; Jiri Lukas; Jiri Bartek
Journal: Cell Cycle Date: 2011-02-01 Impact factor: 4.534

Review 6. Gene silencing in X-chromosome inactivation: advances in understanding facultative heterochromatin formation.

Authors: Anton Wutz
Journal: Nat Rev Genet Date: 2011-07-18 Impact factor: 53.242

7. Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer.

Authors: Raffaella Di Micco; Gabriele Sulli; Miryana Dobreva; Michalis Liontos; Oronza A Botrugno; Gaetano Gargiulo; Roberto dal Zuffo; Valentina Matti; Giovanni d'Ario; Erica Montani; Ciro Mercurio; William C Hahn; Vassilis Gorgoulis; Saverio Minucci; Fabrizio d'Adda di Fagagna
Journal: Nat Cell Biol Date: 2011-02-20 Impact factor: 28.824

8. p16(INK4a) suppression by glucose restriction contributes to human cellular lifespan extension through SIRT1-mediated epigenetic and genetic mechanisms.

Authors: Yuanyuan Li; Trygve O Tollefsbol
Journal: PLoS One Date: 2011-02-24 Impact factor: 3.240

9. Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila.

Authors: Camilla Burnett; Sara Valentini; Filipe Cabreiro; Martin Goss; Milán Somogyvári; Matthew D Piper; Matthew Hoddinott; George L Sutphin; Vid Leko; Joshua J McElwee; Rafael P Vazquez-Manrique; Anne-Marie Orfila; Daniel Ackerman; Catherine Au; Giovanna Vinti; Michèle Riesen; Ken Howard; Christian Neri; Antonio Bedalov; Matt Kaeberlein; Csaba Soti; Linda Partridge; David Gems
Journal: Nature Date: 2011-09-21 Impact factor: 49.962

10. Heterochromatin formation promotes longevity and represses ribosomal RNA synthesis.

Authors: Kimberly Larson; Shian-Jang Yan; Amy Tsurumi; Jacqueline Liu; Jun Zhou; Kriti Gaur; Dongdong Guo; Thomas H Eickbush; Willis X Li
Journal: PLoS Genet Date: 2012-01-26 Impact factor: 5.917

60 in total

Review 1. Epigenetic regulation of ageing: linking environmental inputs to genomic stability.

Authors: Bérénice A Benayoun; Elizabeth A Pollina; Anne Brunet
Journal: Nat Rev Mol Cell Biol Date: 2015-09-16 Impact factor: 94.444

Review 2. Histone methylation and aging: lessons learned from model systems.

Authors: Brenna S McCauley; Weiwei Dang
Journal: Biochim Biophys Acta Date: 2014-05-21

Review 3. Genetic and epigenetic regulation of human aging and longevity.

Authors: Brian J Morris; Bradley J Willcox; Timothy A Donlon
Journal: Biochim Biophys Acta Mol Basis Dis Date: 2018-09-01 Impact factor: 5.187

4. The mechanism of ageing: primary role of transposable elements in genome disintegration.

Authors: Ádám Sturm; Zoltán Ivics; Tibor Vellai
Journal: Cell Mol Life Sci Date: 2015-04-03 Impact factor: 9.261

Review 5. DNA double strand break repair, aging and the chromatin connection.

Authors: Vera Gorbunova; Andrei Seluanov
Journal: Mutat Res Date: 2016-02-15 Impact factor: 2.433

6. SIRT6: a new guardian of mitosis.

Authors: Barbara Martinez Pastor; Raul Mostoslavsky
Journal: Nat Struct Mol Biol Date: 2016-05-04 Impact factor: 15.369

Review 7. DNA damage, chromatin, and transcription: the trinity of aging.

Authors: Rebecca C Burgess; Tom Misteli; Philipp Oberdoerffer
Journal: Curr Opin Cell Biol Date: 2012-08-17 Impact factor: 8.382

Review 8. New Insights into the Regulation of Heterochromatin.

Authors: Jiyong Wang; Sharon T Jia; Songtao Jia
Journal: Trends Genet Date: 2016-03-20 Impact factor: 11.639

Review 9. Transcriptional and epigenetic regulation of autophagy in aging.

Authors: Louis R Lapierre; Caroline Kumsta; Marco Sandri; Andrea Ballabio; Malene Hansen
Journal: Autophagy Date: 2015 Impact factor: 16.016

Review 10. The hallmarks of aging.

Authors: Carlos López-Otín; Maria A Blasco; Linda Partridge; Manuel Serrano; Guido Kroemer
Journal: Cell Date: 2013-06-06 Impact factor: 41.582