Literature DB >> 22902297

DNA damage, chromatin, and transcription: the trinity of aging.

Rebecca C Burgess1, Tom Misteli, Philipp Oberdoerffer.   

Abstract

Aging brings about numerous cellular defects. Amongst the most prominent are elevated levels of persistent DNA damage, changes to chromatin structure and epigenetic modifications, and alterations of global transcription programs. These are not independent events and recent work begins to shed light on the intricate interplay between these aging-related defects. Published by Elsevier Ltd.

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Year:  2012        PMID： 22902297      PMCID： PMC3524355          DOI： 10.1016/j.ceb.2012.07.005

Source DB:  PubMed          Journal:  Curr Opin Cell Biol        ISSN： 0955-0674            Impact factor:   8.382


  61 in total

Review 1.  DNA repair, genome stability, and aging.

Authors:  David B Lombard; Katrin F Chua; Raul Mostoslavsky; Sonia Franco; Monica Gostissa; Frederick W Alt
Journal:  Cell       Date:  2005-02-25       Impact factor: 41.582

2.  Inactivation of the SR protein splicing factor ASF/SF2 results in genomic instability.

Authors:  Xialu Li; James L Manley
Journal:  Cell       Date:  2005-08-12       Impact factor: 41.582

3.  Increased cell-to-cell variation in gene expression in ageing mouse heart.

Authors:  Rumana Bahar; Claudia H Hartmann; Karl A Rodriguez; Ashley D Denny; Rita A Busuttil; Martijn E T Dollé; R Brent Calder; Gary B Chisholm; Brad H Pollock; Christoph A Klein; Jan Vijg
Journal:  Nature       Date:  2006-06-22       Impact factor: 49.962

4.  Genomic instability and aging-like phenotype in the absence of mammalian SIRT6.

Authors:  Raul Mostoslavsky; Katrin F Chua; David B Lombard; Wendy W Pang; Miriam R Fischer; Lionel Gellon; Pingfang Liu; Gustavo Mostoslavsky; Sonia Franco; Michael M Murphy; Kevin D Mills; Parin Patel; Joyce T Hsu; Andrew L Hong; Ethan Ford; Hwei-Ling Cheng; Caitlin Kennedy; Nomeli Nunez; Roderick Bronson; David Frendewey; Wojtek Auerbach; David Valenzuela; Margaret Karow; Michael O Hottiger; Stephen Hursting; J Carl Barrett; Leonard Guarente; Richard Mulligan; Bruce Demple; George D Yancopoulos; Frederick W Alt
Journal:  Cell       Date:  2006-01-27       Impact factor: 41.582

5.  Extrachromosomal rDNA circles--a cause of aging in yeast.

Authors:  D A Sinclair; L Guarente
Journal:  Cell       Date:  1997-12-26       Impact factor: 41.582

6.  Lamin A-dependent nuclear defects in human aging.

Authors:  Paola Scaffidi; Tom Misteli
Journal:  Science       Date:  2006-04-27       Impact factor: 47.728

Review 7.  Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors.

Authors:  Judith Campisi
Journal:  Cell       Date:  2005-02-25       Impact factor: 41.582

8.  ATM phosphorylates histone H2AX in response to DNA double-strand breaks.

Authors:  S Burma; B P Chen; M Murphy; A Kurimasa; D J Chen
Journal:  J Biol Chem       Date:  2001-09-24       Impact factor: 5.157

9.  Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks.

Authors:  Olga A Sedelnikova; Izumi Horikawa; Drazen B Zimonjic; Nicholas C Popescu; William M Bonner; J Carl Barrett
Journal:  Nat Cell Biol       Date:  2004-02       Impact factor: 28.824

10.  Megabase chromatin domains involved in DNA double-strand breaks in vivo.

Authors:  E P Rogakou; C Boon; C Redon; W M Bonner
Journal:  J Cell Biol       Date:  1999-09-06       Impact factor: 10.539
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  25 in total

Review 1.  Epigenetic regulation of ageing: linking environmental inputs to genomic stability.

Authors:  Bérénice A Benayoun; Elizabeth A Pollina; Anne Brunet
Journal:  Nat Rev Mol Cell Biol       Date:  2015-09-16       Impact factor: 94.444

2.  Suppression of transcriptional drift extends C. elegans lifespan by postponing the onset of mortality.

Authors:  Sunitha Rangaraju; Gregory M Solis; Ryan C Thompson; Rafael L Gomez-Amaro; Leo Kurian; Sandra E Encalada; Alexander B Niculescu; Daniel R Salomon; Michael Petrascheck
Journal:  Elife       Date:  2015-12-01       Impact factor: 8.140

Review 3.  The aging hematopoietic stem cell niche: Phenotypic and functional changes and mechanisms that contribute to hematopoietic aging.

Authors:  Sarah E Latchney; Laura M Calvi
Journal:  Semin Hematol       Date:  2016-10-19       Impact factor: 3.851

Review 4.  Histone methylation and aging: lessons learned from model systems.

Authors:  Brenna S McCauley; Weiwei Dang
Journal:  Biochim Biophys Acta       Date:  2014-05-21

Review 5.  The ageing haematopoietic stem cell compartment.

Authors:  Hartmut Geiger; Gerald de Haan; M Carolina Florian
Journal:  Nat Rev Immunol       Date:  2013-04-15       Impact factor: 53.106

Review 6.  The Aging Epigenome.

Authors:  Lauren N Booth; Anne Brunet
Journal:  Mol Cell       Date:  2016-06-02       Impact factor: 17.970

7.  Next-generation sequencing reveals two populations of damage-induced small RNAs at endogenous DNA double-strand breaks.

Authors:  Franziska Bonath; Judit Domingo-Prim; Marcel Tarbier; Marc R Friedländer; Neus Visa
Journal:  Nucleic Acids Res       Date:  2018-12-14       Impact factor: 16.971

8.  Reactive oxygen species generation by copper(II) oxide nanoparticles determined by DNA damage assays and EPR spectroscopy.

Authors:  Carlos Angelé-Martínez; Khanh Van T Nguyen; Fathima S Ameer; Jeffrey N Anker; Julia L Brumaghim
Journal:  Nanotoxicology       Date:  2017-03       Impact factor: 5.913

Review 9.  A chromatin perspective on metabolic and genotoxic impacts on hematopoietic stem and progenitor cells.

Authors:  Zhenhua Yang; Hao Jiang
Journal:  Cell Mol Life Sci       Date:  2020-04-21       Impact factor: 9.261

Review 10.  Common features of chromatin in aging and cancer: cause or coincidence?

Authors:  Linda Zane; Vivek Sharma; Tom Misteli
Journal:  Trends Cell Biol       Date:  2014-08-04       Impact factor: 20.808
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