Literature DB >> 26373265

Epigenetic regulation of ageing: linking environmental inputs to genomic stability.

Bérénice A Benayoun1,2, Elizabeth A Pollina1,3, Anne Brunet1,2,3.   

Abstract

Ageing is affected by both genetic and non-genetic factors. Here, we review the chromatin-based epigenetic changes that occur during ageing, the role of chromatin modifiers in modulating lifespan and the importance of epigenetic signatures as biomarkers of ageing. We also discuss how epigenome remodelling by environmental stimuli affects several aspects of transcription and genomic stability, with important consequences for longevity, and outline epigenetic differences between the 'mortal soma' and the 'immortal germ line'. Finally, we discuss the inheritance of characteristics of ageing and potential chromatin-based strategies to delay or reverse hallmarks of ageing or age-related diseases.

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Year:  2015        PMID： 26373265      PMCID： PMC4736728          DOI： 10.1038/nrm4048

Source DB:  PubMed          Journal:  Nat Rev Mol Cell Biol        ISSN： 1471-0072            Impact factor:   94.444


  194 in total

1.  N6-methyladenine DNA modification in Drosophila.

Authors:  Guoqiang Zhang; Hua Huang; Di Liu; Ying Cheng; Xiaoling Liu; Wenxin Zhang; Ruichuan Yin; Dapeng Zhang; Peng Zhang; Jianzhao Liu; Chaoyi Li; Baodong Liu; Yuewan Luo; Yuanxiang Zhu; Ning Zhang; Shunmin He; Chuan He; Hailin Wang; Dahua Chen
Journal:  Cell       Date:  2015-04-30       Impact factor: 41.582

2.  Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient mice.

Authors:  Vaidehi Krishnan; Maggie Zi Ying Chow; Zimei Wang; Le Zhang; Baohua Liu; Xinguang Liu; Zhongjun Zhou
Journal:  Proc Natl Acad Sci U S A       Date:  2011-07-11       Impact factor: 11.205

Review 3.  Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders.

Authors:  Katrina J Falkenberg; Ricky W Johnstone
Journal:  Nat Rev Drug Discov       Date:  2014-08-18       Impact factor: 84.694

Review 4.  PIWI proteins and PIWI-interacting RNAs in the soma.

Authors:  Robert J Ross; Molly M Weiner; Haifan Lin
Journal:  Nature       Date:  2014-01-16       Impact factor: 49.962

5.  Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice.

Authors:  Rui-Hong Wang; Kundan Sengupta; Cuiling Li; Hyun-Seok Kim; Liu Cao; Cuiying Xiao; Sangsoo Kim; Xiaoling Xu; Yin Zheng; Beverly Chilton; Rong Jia; Zhi-Ming Zheng; Ettore Appella; Xin Wei Wang; Thomas Ried; Chu-Xia Deng
Journal:  Cancer Cell       Date:  2008-10-07       Impact factor: 31.743

6.  Cryptochrome restores dampened circadian rhythms and promotes healthspan in aging Drosophila.

Authors:  Kuntol Rakshit; Jadwiga M Giebultowicz
Journal:  Aging Cell       Date:  2013-06-25       Impact factor: 9.304

7.  An epigenetic blockade of cognitive functions in the neurodegenerating brain.

Authors:  Johannes Gräff; Damien Rei; Ji-Song Guan; Wen-Yuan Wang; Jinsoo Seo; Krista M Hennig; Thomas J F Nieland; Daniel M Fass; Patricia F Kao; Martin Kahn; Susan C Su; Alireza Samiei; Nadine Joseph; Stephen J Haggarty; Ivana Delalle; Li-Huei Tsai
Journal:  Nature       Date:  2012-02-29       Impact factor: 49.962

8.  Epigenetic predictor of age.

Authors:  Sven Bocklandt; Wen Lin; Mary E Sehl; Francisco J Sánchez; Janet S Sinsheimer; Steve Horvath; Eric Vilain
Journal:  PLoS One       Date:  2011-06-22       Impact factor: 3.240

9.  Accelerated epigenetic aging in Down syndrome.

Authors:  Steve Horvath; Paolo Garagnani; Maria Giulia Bacalini; Chiara Pirazzini; Stefano Salvioli; Davide Gentilini; Anna Maria Di Blasio; Cristina Giuliani; Spencer Tung; Harry V Vinters; Claudio Franceschi
Journal:  Aging Cell       Date:  2015-02-09       Impact factor: 9.304

10.  Aging of blood can be tracked by DNA methylation changes at just three CpG sites.

Authors:  Carola Ingrid Weidner; Qiong Lin; Carmen Maike Koch; Lewin Eisele; Fabian Beier; Patrick Ziegler; Dirk Olaf Bauerschlag; Karl-Heinz Jöckel; Raimund Erbel; Thomas Walter Mühleisen; Martin Zenke; Tim Henrik Brümmendorf; Wolfgang Wagner
Journal:  Genome Biol       Date:  2014-02-03       Impact factor: 13.583
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  215 in total

1.  Epigenetic landscape of the TERT promoter: a potential biomarker for high risk AML/MDS.

Authors:  Xin Zhao; Xin Tian; Sachiko Kajigaya; Caroline R Cantilena; Stephen Strickland; Bipin N Savani; Sanjay Mohan; Xingmin Feng; Keyvan Keyvanfar; Neil Dunavin; Danielle M Townsley; Bogdan Dumitriu; Minoo Battiwalla; Katayoun Rezvani; Neal S Young; A John Barrett; Sawa Ito
Journal:  Br J Haematol       Date:  2016-07-19       Impact factor: 6.998

2.  Single-Cell Chromatin Modification Profiling Reveals Increased Epigenetic Variations with Aging.

Authors:  Peggie Cheung; Francesco Vallania; Hayley C Warsinske; Michele Donato; Steven Schaffert; Sarah E Chang; Mai Dvorak; Cornelia L Dekker; Mark M Davis; Paul J Utz; Purvesh Khatri; Alex J Kuo
Journal:  Cell       Date:  2018-04-26       Impact factor: 41.582

Review 3.  Endothelial dysfunction and angiogenesis impairment in the ageing vasculature.

Authors:  Zoltan Ungvari; Stefano Tarantini; Tamas Kiss; Jonathan D Wren; Cory B Giles; Courtney T Griffin; Walter Lee Murfee; Pal Pacher; Anna Csiszar
Journal:  Nat Rev Cardiol       Date:  2018-09       Impact factor: 32.419

Review 4.  Genetic and epigenetic regulation of human aging and longevity.

Authors:  Brian J Morris; Bradley J Willcox; Timothy A Donlon
Journal:  Biochim Biophys Acta Mol Basis Dis       Date:  2018-09-01       Impact factor: 5.187

5.  Calorie restriction breaks an epigenetic barrier to longevity.

Authors:  Diego Molina-Serrano; Antonis Kirmizis
Journal:  Cell Cycle       Date:  2017-03-20       Impact factor: 4.534

6.  Distinct cellular and molecular environments support aging-related DNA methylation changes in the substantia nigra.

Authors:  Maria Fasolino; Shuo Liu; Yinsheng Wang; Zhaolan Zhou
Journal:  Epigenomics       Date:  2016-12-16       Impact factor: 4.778

Review 7.  Mechanisms of intergenerational transmission of polycystic ovary syndrome.

Authors:  Daniel A Dumesic; Luis R Hoyos; Gregorio D Chazenbalk; Rajanigandha Naik; Vasantha Padmanabhan; David H Abbott
Journal:  Reproduction       Date:  2020-01       Impact factor: 3.906

8.  Remodeling of the H3 nucleosomal landscape during mouse aging.

Authors:  Yilin Chen; Juan I Bravo; Jyung Mean Son; Changhan Lee; Bérénice A Benayoun
Journal:  Transl Med Aging       Date:  2020-01-03

9.  Age-associated epigenetic change in chimpanzees and humans.

Authors:  Elaine E Guevara; Richard R Lawler; Nicky Staes; Cassandra M White; Chet C Sherwood; John J Ely; William D Hopkins; Brenda J Bradley
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2020-09-21       Impact factor: 6.237

10.  Chromatin-modifying genetic interventions suppress age-associated transposable element activation and extend life span in Drosophila.

Authors:  Jason G Wood; Brian C Jones; Nan Jiang; Chengyi Chang; Suzanne Hosier; Priyan Wickremesinghe; Meyrolin Garcia; Davis A Hartnett; Lucas Burhenn; Nicola Neretti; Stephen L Helfand
Journal:  Proc Natl Acad Sci U S A       Date:  2016-09-12       Impact factor: 11.205
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