Literature DB >> 22616979

A general, enantioselective synthesis of protected morpholines and piperazines.

Matthew C O'Reilly1, Craig W Lindsley.   

Abstract

A short, high yielding protocol has been developed for the enantioselective and general synthesis of C2-functionalized, benzyl protected morpholines and orthogonally N,N'-protected piperazines from a common intermediate.

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Year:  2012        PMID： 22616979      PMCID： PMC3369273          DOI： 10.1021/ol301203z

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  11 in total

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5.  3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor.

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6.  Synthesis and structure-activity relationships of 7-(2-aminoalkyl)morpholinoquinolones as anti-Helicobacter pylori agents.

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7.  Synthesis, antibacterial evaluation and QSAR studies of 7-[4-(5-aryl-1,3,4-oxadiazole-2-yl)piperazinyl] quinolone derivatives.

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Review 9.  The selective norepinephrine reuptake inhibitor antidepressant reboxetine: pharmacological and clinical profile.

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10.  Enantioselective synthesis of C2-functionalized, N-protected morpholines and orthogonally N,N'-protected piperazines via organocatalysis.

Authors:  Matthew C O'Reilly; Craig W Lindsley
Journal:  Tetrahedron Lett       Date:  2011-12-29       Impact factor: 2.415
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Review 6.  Recent progress toward the asymmetric synthesis of carbon-substituted piperazine pharmacophores and oxidative related heterocycles.

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7.  Asymmetric hydrogenation for the synthesis of 2-substituted chiral morpholines.

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8.  A general, enantioselective synthesis of N-alkyl terminal aziridines and C2-functionalized azetidines via organocatalysis.

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9.  Expedient syntheses of N-heterocycles via intermolecular amphoteric diamination of allenes.

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  9 in total

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