| Literature DB >> 20552963 |
Olugbeminiyi O Fadeyi1, Michael L Schulte, Craig W Lindsley.
Abstract
A three step, one-pot protocol involving enantioselective alpha-chlorination of aldehydes, subsequent reductive amination with a primary amine, and S(N)2 displacement to afford chiral N-alkyl terminal aziridines in 40-65% yield (74-87%/step) and, in most cases, >90% ee is reported.Entities:
Mesh：
Substances：
Year: 2010 PMID： 20552963 DOI： 10.1021/ol101276x
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005