Literature DB >> 9873510

Synthesis and structure-activity relationships of 7-(2-aminoalkyl)morpholinoquinolones as anti-Helicobacter pylori agents.

N Sakurai1, M Sano, F Hirayama, T Kuroda, S Uemori, A Moriguchi, K Yamamoto, Y Ikeda, T Kawakita.   

Abstract

A series of the titled compounds was synthesized and tested for anti-Helicobacter pylori activities. We discovered Y-34867 having the most potent activity against Helicobacter pylori among the quinolones tested along with high photostability. Furthermore, Y-34867 showed an excellent therapeutic effect in the experimental Helicobacter pylori infected Mongolian gerbil model.

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Year:  1998        PMID: 9873510     DOI: 10.1016/s0960-894x(98)00390-4

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  2 in total

1.  A general, enantioselective synthesis of protected morpholines and piperazines.

Authors:  Matthew C O'Reilly; Craig W Lindsley
Journal:  Org Lett       Date:  2012-05-22       Impact factor: 6.005

2.  Enantioselective synthesis of C2-functionalized, N-protected morpholines and orthogonally N,N'-protected piperazines via organocatalysis.

Authors:  Matthew C O'Reilly; Craig W Lindsley
Journal:  Tetrahedron Lett       Date:  2011-12-29       Impact factor: 2.415

  2 in total

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