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Literature DB >> 22573913

Considerations in the design of clinical trials for cognitive aging.

Eric M Reiman¹, Roberta Diaz Brinton, Russell Katz, Ronald C Petersen, Selam Negash, Dan Mungas, Paul S Aisen.

Abstract

What will it take to develop interventions for the treatment of age-related cognitive decline? Session V of the Summit provided perspectives on the design of clinical trials to evaluate promising but unproven interventions, and some of the steps needed to accelerate the discovery and evaluation of promising treatments. It considered strategies to further characterize the biological and cognitive changes associated with normal aging and their translation into the development of new treatments. It provided regulatory, scientific, and clinical perspectives about neurocognitive aging treatments, their potential benefits and risks, and the strategies and endpoints needed to evaluate them in the most rapid, rigorous, and clinically meaningful way. It considered lessons learned from the study of Alzheimer's disease, the promising roles of biomarkers in neurocognitive aging research, and ways to help galvanize the scientific study and treatment of neurocognitive aging.

Entities: Disease

Mesh：

Substances：

Year: 2012 PMID： 22573913 PMCID： PMC3391068 DOI： 10.1093/gerona/gls124

Source DB: PubMed Journal: J Gerontol A Biol Sci Med Sci ISSN： 1079-5006 Impact factor: 6.053

18 in total

1. Imaging correlates of brain function in monkeys and rats isolates a hippocampal subregion differentially vulnerable to aging.

Authors: Scott A Small; Monica K Chawla; Michael Buonocore; Peter R Rapp; Carol A Barnes
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2. Spanish and English Neuropsychological Assessment Scales (SENAS): further development and psychometric characteristics.

Authors: Dan Mungas; Bruce R Reed; Paul K Crane; Mary N Haan; Hector González
Journal: Psychol Assess Date: 2004-12

3. Regional network of magnetic resonance imaging gray matter volume in healthy aging.

Authors: Gene E Alexander; Kewei Chen; Tricia L Merkley; Eric M Reiman; Richard J Caselli; Melaney Aschenbrenner; Laura Santerre-Lemmon; Diana J Lewis; Pietro Pietrini; Stefan J Teipel; Harald Hampel; Stanley I Rapoport; James R Moeller
Journal: Neuroreport Date: 2006-07-17 Impact factor: 1.837

4. Decrease of frontal metabolism demonstrated by positron emission tomography in a population of healthy elderly volunteers.

Authors: E Salmon; P Maquet; B Sadzot; C Degueldre; C Lemaire; G Franck
Journal: Acta Neurol Belg Date: 1991 Impact factor: 2.396

5. Common Kibra alleles are associated with human memory performance.

Authors: Andreas Papassotiropoulos; Dietrich A Stephan; Matthew J Huentelman; Frederic J Hoerndli; David W Craig; John V Pearson; Kim-Dung Huynh; Fabienne Brunner; Jason Corneveaux; David Osborne; M Axel Wollmer; Amanda Aerni; Daniel Coluccia; Jürgen Hänggi; Christian R A Mondadori; Andreas Buchmann; Eric M Reiman; Richard J Caselli; Katharina Henke; Dominique J-F de Quervain
Journal: Science Date: 2006-10-20 Impact factor: 47.728

6. Application of item response theory for development of a global functioning measure of dementia with linear measurement properties.

Authors: D Mungas; B R Reed
Journal: Stat Med Date: 2000 Jun 15-30 Impact factor: 2.373

Review 7. Shift in brain metabolism in late onset Alzheimer's disease: implications for biomarkers and therapeutic interventions.

Authors: Jia Yao; Jamaica R Rettberg; Lauren P Klosinski; Enrique Cadenas; Roberta Diaz Brinton
Journal: Mol Aspects Med Date: 2011-10-21

8. Age-related alterations in white matter microstructure measured by diffusion tensor imaging.

Authors: D H Salat; D S Tuch; D N Greve; A J W van der Kouwe; N D Hevelone; A K Zaleta; B R Rosen; B Fischl; S Corkin; H Diana Rosas; A M Dale
Journal: Neurobiol Aging Date: 2004-12-19 Impact factor: 4.673

9. Gene expression profiles in anatomically and functionally distinct regions of the normal aged human brain.

Authors: Winnie S Liang; Travis Dunckley; Thomas G Beach; Andrew Grover; Diego Mastroeni; Douglas G Walker; Richard J Caselli; Walter A Kukull; Daniel McKeel; John C Morris; Christine Hulette; Donald Schmechel; Gene E Alexander; Eric M Reiman; Joseph Rogers; Dietrich A Stephan
Journal: Physiol Genomics Date: 2006-10-31 Impact factor: 3.107

10. Design, synthesis, and estrogenic activity of a novel estrogen receptor modulator--a hybrid structure of 17beta-estradiol and vitamin E in hippocampal neurons.

Authors: Liqin Zhao; Chunyang Jin; Zisu Mao; Madathil B Gopinathan; Kenneth Rehder; Roberta D Brinton
Journal: J Med Chem Date: 2007-08-14 Impact factor: 7.446

8 in total

1. APOE moderates the association between lifestyle activities and cognitive performance: evidence of genetic plasticity in aging.

Authors: Shannon K Runge; Brent J Small; G Peggy McFall; Roger A Dixon
Journal: J Int Neuropsychol Soc Date: 2014-05 Impact factor: 2.892

Review 2. Symptom onset in autosomal dominant Alzheimer disease: a systematic review and meta-analysis.

Authors: Davis C Ryman; Natalia Acosta-Baena; Paul S Aisen; Thomas Bird; Adrian Danek; Nick C Fox; Alison Goate; Peter Frommelt; Bernardino Ghetti; Jessica B S Langbaum; Francisco Lopera; Ralph Martins; Colin L Masters; Richard P Mayeux; Eric McDade; Sonia Moreno; Eric M Reiman; John M Ringman; Steve Salloway; Peter R Schofield; Reisa Sperling; Pierre N Tariot; Chengjie Xiong; John C Morris; Randall J Bateman
Journal: Neurology Date: 2014-06-13 Impact factor: 9.910

Considerations in the design of clinical trials for cognitive aging.

1. Imaging correlates of brain function in monkeys and rats isolates a hippocampal subregion differentially vulnerable to aging.

2. Spanish and English Neuropsychological Assessment Scales (SENAS): further development and psychometric characteristics.

3. Regional network of magnetic resonance imaging gray matter volume in healthy aging.

4. Decrease of frontal metabolism demonstrated by positron emission tomography in a population of healthy elderly volunteers.

5. Common Kibra alleles are associated with human memory performance.

6. Application of item response theory for development of a global functioning measure of dementia with linear measurement properties.

Review 7. Shift in brain metabolism in late onset Alzheimer's disease: implications for biomarkers and therapeutic interventions.

8. Age-related alterations in white matter microstructure measured by diffusion tensor imaging.

9. Gene expression profiles in anatomically and functionally distinct regions of the normal aged human brain.

10. Design, synthesis, and estrogenic activity of a novel estrogen receptor modulator--a hybrid structure of 17beta-estradiol and vitamin E in hippocampal neurons.

1. APOE moderates the association between lifestyle activities and cognitive performance: evidence of genetic plasticity in aging.

Review 2. Symptom onset in autosomal dominant Alzheimer disease: a systematic review and meta-analysis.

Review 3. Molecular aspects of age-related cognitive decline: the role of GABA signaling.

Review 4. Targeting the prodromal stage of Alzheimer's disease: bioenergetic and mitochondrial opportunities.

5. Advances in designs for Alzheimer's disease clinical trials.

6. Prognostic classification of mild cognitive impairment and Alzheimer's disease: MRI independent component analysis.

7. Plasma Extracellular Vesicles Enriched for Neuronal Origin: A Potential Window into Brain Pathologic Processes.

8. Thalamo-cortical inter-subject functional correlation during movie watching across the adult lifespan.