Literature DB >> 1781265

Decrease of frontal metabolism demonstrated by positron emission tomography in a population of healthy elderly volunteers.

E Salmon1, P Maquet, B Sadzot, C Degueldre, C Lemaire, G Franck.   

Abstract

Frontal metabolism measured with positron emission tomography is shown to be decreased relatively to that in other cortical or sub-cortical areas, in a population of healthy elderly compared to young volunteers. Cortical atrophy or neuronal depopulation are unlikely to entirely explain this physiological phenomenon, and sub-cortico-cortical deactivation should play a role, analogous to that proposed in subcortical diseases.

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Year:  1991        PMID： 1781265

Source DB:  PubMed          Journal:  Acta Neurol Belg        ISSN： 0300-9009            Impact factor:   2.396


  9 in total

Review 1.  Considerations in the design of clinical trials for cognitive aging.

Authors:  Eric M Reiman; Roberta Diaz Brinton; Russell Katz; Ronald C Petersen; Selam Negash; Dan Mungas; Paul S Aisen
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2012-05-09       Impact factor: 6.053

2.  Higher serum total cholesterol levels in late middle age are associated with glucose hypometabolism in brain regions affected by Alzheimer's disease and normal aging.

Authors:  Eric M Reiman; Kewei Chen; Jessica B S Langbaum; Wendy Lee; Cole Reschke; Daniel Bandy; Gene E Alexander; Richard J Caselli
Journal:  Neuroimage       Date:  2009-07-23       Impact factor: 6.556

3.  Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia.

Authors:  Eric M Reiman; Kewei Chen; Gene E Alexander; Richard J Caselli; Daniel Bandy; David Osborne; Ann M Saunders; John Hardy
Journal:  Proc Natl Acad Sci U S A       Date:  2003-12-19       Impact factor: 11.205

4.  Gene expression profiles in anatomically and functionally distinct regions of the normal aged human brain.

Authors:  Winnie S Liang; Travis Dunckley; Thomas G Beach; Andrew Grover; Diego Mastroeni; Douglas G Walker; Richard J Caselli; Walter A Kukull; Daniel McKeel; John C Morris; Christine Hulette; Donald Schmechel; Gene E Alexander; Eric M Reiman; Joseph Rogers; Dietrich A Stephan
Journal:  Physiol Genomics       Date:  2006-10-31       Impact factor: 3.107

5.  Brain FDG PET study of normal aging in Japanese: effect of atrophy correction.

Authors:  Daisuke Yanase; Ichiro Matsunari; Kazuyoshi Yajima; Weiping Chen; Akihiko Fujikawa; Shintaro Nishimura; Hiroshi Matsuda; Masahito Yamada
Journal:  Eur J Nucl Med Mol Imaging       Date:  2005-03-10       Impact factor: 9.236

6.  Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease.

Authors:  Fei Liu; Jianhua Shi; Hitoshi Tanimukai; Jinhua Gu; Jianlan Gu; Inge Grundke-Iqbal; Khalid Iqbal; Cheng-Xin Gong
Journal:  Brain       Date:  2009-05-18       Impact factor: 13.501

7.  Linking functional and structural brain images with multivariate network analyses: a novel application of the partial least square method.

Authors:  Kewei Chen; Eric M Reiman; Zhongdan Huan; Richard J Caselli; Daniel Bandy; Napatkamon Ayutyanont; Gene E Alexander
Journal:  Neuroimage       Date:  2009-04-23       Impact factor: 6.556

8.  Brain aging research at the close of the 20th century: from bench to bedside.

Authors:  C Cidis Meltzer; P T Francis
Journal:  Dialogues Clin Neurosci       Date:  2001-09       Impact factor: 5.986

9.  The relationship between cerebral glucose metabolism and age: report of a large brain PET data set.

Authors:  Xiaoyan Shen; Huafeng Liu; Zhenghui Hu; Hongjie Hu; Pengcheng Shi
Journal:  PLoS One       Date:  2012-12-20       Impact factor: 3.240
  9 in total

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