| Literature DB >> 17053149 |
Andreas Papassotiropoulos1, Dietrich A Stephan, Matthew J Huentelman, Frederic J Hoerndli, David W Craig, John V Pearson, Kim-Dung Huynh, Fabienne Brunner, Jason Corneveaux, David Osborne, M Axel Wollmer, Amanda Aerni, Daniel Coluccia, Jürgen Hänggi, Christian R A Mondadori, Andreas Buchmann, Eric M Reiman, Richard J Caselli, Katharina Henke, Dominique J-F de Quervain.
Abstract
Human memory is a polygenic trait. We performed a genome-wide screen to identify memory-related gene variants. A genomic locus encoding the brain protein KIBRA was significantly associated with memory performance in three independent, cognitively normal cohorts from Switzerland and the United States. Gene expression studies showed that KIBRA was expressed in memory-related brain structures. Functional magnetic resonance imaging detected KIBRA allele-dependent differences in hippocampal activations during memory retrieval. Evidence from these experiments suggests a role for KIBRA in human memory.Entities:
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Year: 2006 PMID： 17053149 DOI： 10.1126/science.1129837
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728