Literature DB >> 26070271

Molecular aspects of age-related cognitive decline: the role of GABA signaling.

Joseph A McQuail1, Charles J Frazier2, Jennifer L Bizon3.   

Abstract

Alterations in inhibitory interneurons contribute to cognitive deficits associated with several psychiatric and neurological diseases. Phasic and tonic inhibition imparted by γ-aminobutyric acid (GABA) receptors regulates neural activity and helps to establish the appropriate network dynamics in cortical circuits that support normal cognition. This review highlights basic science demonstrating that inhibitory signaling is altered in aging, and discusses the impact of age-related shifts in inhibition on different forms of memory function, including hippocampus-dependent spatial reference memory and prefrontal cortex (PFC)-dependent working memory. The clinical appropriateness and tractability of select therapeutic candidates for cognitive aging that target receptors mediating inhibition are also discussed.
Copyright © 2015 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  GABA(A) α5; GABA(B) receptor; hippocampus; memory; prefrontal cortex; tonic inhibition

Mesh：

Substances：

Year:  2015        PMID： 26070271      PMCID： PMC4500156          DOI： 10.1016/j.molmed.2015.05.002

Source DB:  PubMed          Journal:  Trends Mol Med        ISSN： 1471-4914            Impact factor:   11.951


  128 in total

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4.  Reducing prefrontal gamma-aminobutyric acid activity induces cognitive, behavioral, and dopaminergic abnormalities that resemble schizophrenia.

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Journal:  Biol Psychiatry       Date:  2010-12-10       Impact factor: 13.382

5.  Adaptive regulation of neuronal excitability by a voltage-independent potassium conductance.

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Journal:  Nature       Date:  2001-01-04       Impact factor: 49.962

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Journal:  Proc Natl Acad Sci U S A       Date:  1991-09-01       Impact factor: 11.205

7.  Spatial reference memory in normal aging Fischer 344 × Brown Norway F1 hybrid rats.

Authors:  Joseph A McQuail; Michelle M Nicolle
Journal:  Neurobiol Aging       Date:  2014-07-03       Impact factor: 4.673

Review 8.  Neuronal diversity and temporal dynamics: the unity of hippocampal circuit operations.

Authors:  Thomas Klausberger; Peter Somogyi
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9.  Synapses are lost during aging in the primate prefrontal cortex.

Authors:  A Peters; C Sethares; J I Luebke
Journal:  Neuroscience       Date:  2007-07-17       Impact factor: 3.590

10.  Characterizing cognitive aging of spatial and contextual memory in animal models.

Authors:  Thomas C Foster; R A Defazio; Jennifer L Bizon
Journal:  Front Aging Neurosci       Date:  2012-09-12       Impact factor: 5.750
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  65 in total

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Authors:  B S Beas; J A McQuail; C Ban Uelos; B Setlow; J L Bizon
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3.  The endocrine-brain-aging triad where many paths meet: female reproductive hormone changes at midlife and their influence on circuits important for learning and memory.

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4.  Adolescent Cannabinoid Use and Cognition; Unexpected Results from a Rat Model of Cannabinoid Self-Administration.

Authors:  Barry Setlow; Jennifer L Bizon
Journal:  Neuropsychopharmacology       Date:  2016-09-22       Impact factor: 7.853

5.  GABAA Receptors in the Mongolian Gerbil: a PET Study Using [18F]Flumazenil to Determine Receptor Binding in Young and Old Animals.

Authors:  M Kessler; M Mamach; R Beutelmann; M Lukacevic; S Eilert; P Bascuñana; A Fasel; F M Bengel; J P Bankstahl; T L Ross; G M Klump; G Berding
Journal:  Mol Imaging Biol       Date:  2020-04       Impact factor: 3.488

6.  Frontal Gamma-Aminobutyric Acid Concentrations Are Associated With Cognitive Performance in Older Adults.

Authors:  Eric C Porges; Adam J Woods; Richard A E Edden; Nicolaas A J Puts; Ashley D Harris; Huaihou Chen; Amanda M Garcia; Talia R Seider; Damon G Lamb; John B Williamson; Ronald A Cohen
Journal:  Biol Psychiatry Cogn Neurosci Neuroimaging       Date:  2017-01

7.  Dissociable effects of advanced age on prefrontal cortical and medial temporal lobe ensemble activity.

Authors:  Abbi R Hernandez; Jordan E Reasor; Leah M Truckenbrod; Keila T Campos; Quinten P Federico; Kaeli E Fertal; Katelyn N Lubke; Sarah A Johnson; Benjamin J Clark; Andrew P Maurer; Sara N Burke
Journal:  Neurobiol Aging       Date:  2018-06-30       Impact factor: 4.673

8.  Significance of inhibitory recruitment in aging with preserved cognition: limiting gamma-aminobutyric acid type A α5 function produces memory impairment.

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9.  Head west or left, east or right: interactions between memory systems in neurocognitive aging.

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10.  Age-related changes in tonic activation of presynaptic versus extrasynaptic γ-amniobutyric acid type B receptors in rat medial prefrontal cortex.

Authors:  Haley E Carpenter; Kyle B Kelly; Jennifer L Bizon; Charles J Frazier
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