Literature DB >> 22549923

Identification of a key prenyltransferase involved in biosynthesis of the most abundant fungal meroterpenoids derived from 3,5-dimethylorsellinic acid.

Takayuki Itoh1, Kinya Tokunaga, Edayileveettil K Radhakrishnan, Isao Fujii, Ikuro Abe, Yutaka Ebizuka, Tetsuo Kushiro.   

Abstract

Destroying aromaticity: A novel prenyltransferase (Trt2) involved in fungal meroterpenoid biosynthesis was shown to catalyze an unusual aromatic addition reaction onto a fully substituted aromatic ring. The prenylated product serves as a key intermediate in the biosynthesis of the most abundant series of meroterpenoids in fungi.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2012        PMID： 22549923     DOI： 10.1002/cbic.201200124

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


  17 in total

1.  An efficient system for heterologous expression of secondary metabolite genes in Aspergillus nidulans.

Authors:  Yi-Ming Chiang; C Elizabeth Oakley; Manmeet Ahuja; Ruth Entwistle; Aric Schultz; Shu-Lin Chang; Calvin T Sung; Clay C C Wang; Berl R Oakley
Journal:  J Am Chem Soc       Date:  2013-05-09       Impact factor: 15.419

2.  Navigating the fungal polyketide chemical space: from genes to molecules.

Authors:  Yit-Heng Chooi; Yi Tang
Journal:  J Org Chem       Date:  2012-09-13       Impact factor: 4.354

3.  Biomimetic Synthesis of Meroterpenoids by Dearomatization-Driven Polycyclization.

Authors:  Zachary Powers; Adam Scharf; Andrea Cheng; Feng Yang; Martin Himmelbauer; Takaaki Mitsuhashi; Lena Barra; Yoshimasa Taniguchi; Takashi Kikuchi; Makoto Fujita; Ikuro Abe; John A Porco
Journal:  Angew Chem Int Ed Engl       Date:  2019-09-25       Impact factor: 15.336

4.  The fumagillin biosynthetic gene cluster in Aspergillus fumigatus encodes a cryptic terpene cyclase involved in the formation of β-trans-bergamotene.

Authors:  Hsiao-Ching Lin; Yit-Heng Chooi; Sourabh Dhingra; Wei Xu; Ana M Calvo; Yi Tang
Journal:  J Am Chem Soc       Date:  2013-03-19       Impact factor: 15.419

5.  Molecular genetic characterization of a cluster in A. terreus for biosynthesis of the meroterpenoid terretonin.

Authors:  Chun-Jun Guo; Benjamin P Knox; Yi-Ming Chiang; Hsien-Chun Lo; James F Sanchez; Kuan-Han Lee; Berl R Oakley; Kenneth S Bruno; Clay C C Wang
Journal:  Org Lett       Date:  2012-11-01       Impact factor: 6.005

6.  Application of an efficient gene targeting system linking secondary metabolites to their biosynthetic genes in Aspergillus terreus.

Authors:  Chun-Jun Guo; Benjamin P Knox; James F Sanchez; Yi-Ming Chiang; Kenneth S Bruno; Clay C C Wang
Journal:  Org Lett       Date:  2013-07-10       Impact factor: 6.005

Review 7.  Terpene synthases in disguise: enzymology, structure, and opportunities of non-canonical terpene synthases.

Authors:  Jeffrey D Rudolf; Chin-Yuan Chang
Journal:  Nat Prod Rep       Date:  2020-03-25       Impact factor: 13.423

Review 8.  Bacterial terpenome.

Authors:  Jeffrey D Rudolf; Tyler A Alsup; Baofu Xu; Zining Li
Journal:  Nat Prod Rep       Date:  2021-05-26       Impact factor: 15.111

9.  Exploiting the Potential of Meroterpenoid Cyclases to Expand the Chemical Space of Fungal Meroterpenoids.

Authors:  Takaaki Mitsuhashi; Lena Barra; Zachary Powers; Volga Kojasoy; Andrea Cheng; Feng Yang; Yoshimasa Taniguchi; Takashi Kikuchi; Makoto Fujita; Dean J Tantillo; John A Porco; Ikuro Abe
Journal:  Angew Chem Int Ed Engl       Date:  2020-10-22       Impact factor: 15.336

10.  Genome-based discovery of a novel membrane-bound 1,6-dihydroxyphenazine prenyltransferase from a marine actinomycete.

Authors:  Philipp Zeyhle; Judith S Bauer; Jörn Kalinowski; Kazuo Shin-ya; Harald Gross; Lutz Heide
Journal:  PLoS One       Date:  2014-06-03       Impact factor: 3.240
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