Literature DB >> 23116177

Molecular genetic characterization of a cluster in A. terreus for biosynthesis of the meroterpenoid terretonin.

Chun-Jun Guo1, Benjamin P Knox, Yi-Ming Chiang, Hsien-Chun Lo, James F Sanchez, Kuan-Han Lee, Berl R Oakley, Kenneth S Bruno, Clay C C Wang.   

Abstract

Meroterpenoids are natural products produced from polyketide and terpenoid precursors. A gene targeting system for A. terreus NIH2624 was developed, and a gene cluster for terretonin biosynthesis was characterized. The intermediates and shunt products were isolated from the mutant strains, and a pathway for terretonin biosynthesis is proposed. Analysis of two meroterpenoid pathways corresponding to terretonin in A. terreus and austinol in A. nidulans reveals that they are closely related evolutionarily.

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Year:  2012        PMID： 23116177      PMCID： PMC3538129          DOI： 10.1021/ol302682z

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  15 in total

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4.  Characterization of a polyketide synthase in Aspergillus niger whose product is a precursor for both dihydroxynaphthalene (DHN) melanin and naphtho-γ-pyrone.

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Journal:  Fungal Genet Biol       Date:  2010-12-19       Impact factor: 3.495

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Review 9.  Meroterpenoids produced by fungi.

Authors:  Regina Geris; Thomas J Simpson
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10.  Structure of human phytanoyl-CoA 2-hydroxylase identifies molecular mechanisms of Refsum disease.

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  28 in total

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Journal:  Proc Natl Acad Sci U S A       Date:  2018-01-09       Impact factor: 11.205

Review 2.  Peculiarities of meroterpenoids and their bioproduction.

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5.  Enfumafungin synthase represents a novel lineage of fungal triterpene cyclases.

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Review 6.  Recent advances in the genome mining of Aspergillus secondary metabolites (covering 2012-2018).

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7.  Traversing Biosynthetic Carbocation Landscapes in the Total Synthesis of Andrastin and Terretonin Meroterpenes.

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8.  Biosynthetic pathway for the epipolythiodioxopiperazine acetylaranotin in Aspergillus terreus revealed by genome-based deletion analysis.

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9.  New natural products isolated from Metarhizium robertsii ARSEF 23 by chemical screening and identification of the gene cluster through engineered biosynthesis in Aspergillus nidulans A1145.

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10.  Application of an efficient gene targeting system linking secondary metabolites to their biosynthetic genes in Aspergillus terreus.

Authors:  Chun-Jun Guo; Benjamin P Knox; James F Sanchez; Yi-Ming Chiang; Kenneth S Bruno; Clay C C Wang
Journal:  Org Lett       Date:  2013-07-10       Impact factor: 6.005
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