Literature DB >> 23841722

Application of an efficient gene targeting system linking secondary metabolites to their biosynthetic genes in Aspergillus terreus.

Chun-Jun Guo1, Benjamin P Knox, James F Sanchez, Yi-Ming Chiang, Kenneth S Bruno, Clay C C Wang.   

Abstract

Nonribosomal peptides (NRPs) are natural products biosynthesized by NRP synthetases. A kusA-, pyrG- mutant strain of Aspergillus terreus NIH 2624 was developed that greatly facilitated the gene targeting efficiency in this organism. Application of this tool allowed us to link four major types of NRP-related secondary metabolites to their responsible genes in A. terreus. In addition, an NRP affecting melanin synthesis was also identified in this species.

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Year:  2013        PMID： 23841722      PMCID： PMC3833251          DOI： 10.1021/ol401384v

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  17 in total

Review 1.  Assembly-line enzymology for polyketide and nonribosomal Peptide antibiotics: logic, machinery, and mechanisms.

Authors:  Michael A Fischbach; Christopher T Walsh
Journal:  Chem Rev       Date:  2006-08       Impact factor: 60.622

Review 2.  Biosynthesis of fungal melanins and their importance for human pathogenic fungi.

Authors:  Kim Langfelder; Martin Streibel; Bernhard Jahn; Gerhard Haase; Axel A Brakhage
Journal:  Fungal Genet Biol       Date:  2003-03       Impact factor: 3.495

3.  Mechanism of the cytotoxicity of asterriquinone, a metabolite of Aspergillus terreus.

Authors:  A Kaji; R Saito; M Nomura; K Miyamoto; N Kiriyama
Journal:  Anticancer Res       Date:  1997 Sep-Oct       Impact factor: 2.480

4.  SMURF: Genomic mapping of fungal secondary metabolite clusters.

Authors:  Nora Khaldi; Fayaz T Seifuddin; Geoff Turner; Daniel Haft; William C Nierman; Kenneth H Wolfe; Natalie D Fedorova
Journal:  Fungal Genet Biol       Date:  2010-06-08       Impact factor: 3.495

5.  Biosynthetic pathway for the epipolythiodioxopiperazine acetylaranotin in Aspergillus terreus revealed by genome-based deletion analysis.

Authors:  Chun-Jun Guo; Hsu-Hua Yeh; Yi-Ming Chiang; James F Sanchez; Shu-Ling Chang; Kenneth S Bruno; Clay C C Wang
Journal:  J Am Chem Soc       Date:  2013-05-01       Impact factor: 15.419

6.  Twenty-five coregulated transcripts define a sterigmatocystin gene cluster in Aspergillus nidulans.

Authors:  D W Brown; J H Yu; H S Kelkar; M Fernandes; T C Nesbitt; N P Keller; T H Adams; T J Leonard
Journal:  Proc Natl Acad Sci U S A       Date:  1996-02-20       Impact factor: 11.205

7.  Polyketide decarboxylative chain termination preceded by o-sulfonation in curacin a biosynthesis.

Authors:  Liangcai Gu; Bo Wang; Amol Kulkarni; Jennifer J Gehret; Kayla R Lloyd; Lena Gerwick; William H Gerwick; Peter Wipf; Kristina Håkansson; Janet L Smith; David H Sherman
Journal:  J Am Chem Soc       Date:  2009-11-11       Impact factor: 15.419

8.  Terrequinone A biosynthesis through L-tryptophan oxidation, dimerization and bisprenylation.

Authors:  Carl J Balibar; Annaleise R Howard-Jones; Christopher T Walsh
Journal:  Nat Chem Biol       Date:  2007-08-12       Impact factor: 15.040

9.  Production of pyomelanin, a second type of melanin, via the tyrosine degradation pathway in Aspergillus fumigatus.

Authors:  Jeannette Schmaler-Ripcke; Venelina Sugareva; Peter Gebhardt; Robert Winkler; Olaf Kniemeyer; Thorsten Heinekamp; Axel A Brakhage
Journal:  Appl Environ Microbiol       Date:  2008-11-21       Impact factor: 4.792

10.  Acetylaszonalenin biosynthesis in Neosartorya fischeri. Identification of the biosynthetic gene cluster by genomic mining and functional proof of the genes by biochemical investigation.

Authors:  Wen-Bing Yin; Alexander Grundmann; Jun Cheng; Shu-Ming Li
Journal:  J Biol Chem       Date:  2008-11-10       Impact factor: 5.157
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  10 in total

Review 1.  Recent advances in the genome mining of Aspergillus secondary metabolites (covering 2012-2018).

Authors:  Jillian Romsdahl; Clay C C Wang
Journal:  Medchemcomm       Date:  2019-04-26       Impact factor: 3.597

2.  Development of versatile and efficient genetic tools for the marine-derived fungus Aspergillus terreus RA2905.

Authors:  Guangshan Yao; Xiaofeng Chen; Yijuan Han; Huawei Zheng; Zonghua Wang; Jianming Chen
Journal:  Curr Genet       Date:  2022-01-19       Impact factor: 3.886

Review 3.  Recent advances in genome mining of secondary metabolites in Aspergillus terreus.

Authors:  Chun-Jun Guo; Clay C C Wang
Journal:  Front Microbiol       Date:  2014-12-23       Impact factor: 5.640

4.  Molecular genetic characterization of terreic acid pathway in Aspergillus terreus.

Authors:  Chun-Jun Guo; Wei-Wen Sun; Kenneth S Bruno; Clay C C Wang
Journal:  Org Lett       Date:  2014-09-29       Impact factor: 6.005

Review 5.  Endogenous cross-talk of fungal metabolites.

Authors:  Kevin J Sheridan; Stephen K Dolan; Sean Doyle
Journal:  Front Microbiol       Date:  2015-01-05       Impact factor: 5.640

6.  Melanisation of Aspergillus terreus-Is Butyrolactone I Involved in the Regulation of Both DOPA and DHN Types of Pigments in Submerged Culture?

Authors:  Elina K Palonen; Sheetal Raina; Annika Brandt; Jussi Meriluoto; Tajalli Keshavarz; Juhani T Soini
Journal:  Microorganisms       Date:  2017-05-04

7.  Spatial regulation of a common precursor from two distinct genes generates metabolite diversity.

Authors:  Chun-Jun Guo; Wei-Wen Sun; Kenneth S Bruno; Berl R Oakley; Nancy P Keller; Clay C C Wang
Journal:  Chem Sci       Date:  2015-07-13       Impact factor: 9.825

8.  Comment on: "Melanisation of Aspergillus terreus-Is Butyrolactone I Involved in the Regulation of Both DOPA and DHN Types of Pigments in Submerged Culture? Microorganisms 2017, 5, 22".

Authors:  Elena Geib; Matthias Brock
Journal:  Microorganisms       Date:  2017-06-21

9.  Characterisation of ascocorynin biosynthesis in the purple jellydisc fungus Ascocoryne sarcoides.

Authors:  Carsten Wieder; Roberta Peres da Silva; Jessica Witts; Christof Martin Jäger; Elena Geib; Matthias Brock
Journal:  Fungal Biol Biotechnol       Date:  2022-04-27

10.  Induction of secondary metabolism of Aspergillus terreus ATCC 20542 in the batch bioreactor cultures.

Authors:  Tomasz Boruta; Marcin Bizukojc
Journal:  Appl Microbiol Biotechnol       Date:  2015-11-25       Impact factor: 4.813
  10 in total

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