Literature DB >> 22522643

Biosynthesis of piperazic acid via N5-hydroxy-ornithine in Kutzneria spp. 744.

Christopher S Neumann1, Wei Jiang, John R Heemstra, Erin A Gontang, Roberto Kolter, Christopher T Walsh.   

Abstract

Which came first? We have investigated the biosynthesis of the piperazic acid (Piz) building blocks in the kutzneride family of metabolites. The flavin-dependent oxygenase KtzI was shown to convert ornithine to N(5)-OH-Orn. LC-MS/MS showed (13)C(5)-labeled versions of these two amino acids to be direct precursors of piperazic acid in vivo.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2012        PMID： 22522643      PMCID： PMC3463134          DOI： 10.1002/cbic.201200054

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


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