Literature DB >> 28628093

A heme-dependent enzyme forms the nitrogen-nitrogen bond in piperazate.

Yi-Ling Du1,2, Hai-Yan He2, Melanie A Higgins2, Katherine S Ryan2.   

Abstract

Molecules containing a nitrogen-nitrogen (N-N) linkage have a variety of structures and biological activities; however, no enzyme has yet been demonstrated to catalyze N-N bond formation in an organic molecule. Here we report that the heme-dependent enzyme KtzT from Kutzneria sp. 744 catalyzes N-N bond formation in the biosynthesis of piperazate, a building block for nonribosomal peptides.

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Year:  2017        PMID： 28628093     DOI： 10.1038/nchembio.2411

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


  23 in total

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Review 7.  Flavin-dependent N-hydroxylating enzymes: distribution and application.

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10.  Aminoacyl sulfonamide assembly in SB-203208 biosynthesis.

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