OBJECTIVE: The TEDDY Study is an international, multi-center prospective study designed to identify the environmental triggers of type 1 diabetes (T1D) in genetically at-risk children. This report investigates ethnic minority (EM) differences in patterns of enrollment and retention in the US centers. METHODS: As of June 2009, 267,739 newborns had been screened at birth for high risk T1D genotypes. Data collected at the time of screening, enrollment and at the baseline visit were used. Descriptive and multiple-logistic regression analyses assessed differences between EM groups regarding exclusion, enrollment and early withdrawal. RESULTS: Of the 10,975 eligible subjects, 6,912 (67%) were invited to participate. EM subjects were more likely to be excluded because of an inability to contact. Of those invited 3,265 (47%) enrolled by the age of 4.5 months. Adjusted analyses showed that except for those classified as other EM, the odds of enrolling were similar across groups. EM subjects had elevated early withdrawal rates. Adjusted models demonstrated that this was significantly more likely among Hispanic subjects. CONCLUSION: Understanding patterns associated with EM participation in research extends our ability to make more accurate inferences and permits assessment of strategies that promote inclusion of EM to better address health disparities.
OBJECTIVE: The TEDDY Study is an international, multi-center prospective study designed to identify the environmental triggers of type 1 diabetes (T1D) in genetically at-risk children. This report investigates ethnic minority (EM) differences in patterns of enrollment and retention in the US centers. METHODS: As of June 2009, 267,739 newborns had been screened at birth for high risk T1D genotypes. Data collected at the time of screening, enrollment and at the baseline visit were used. Descriptive and multiple-logistic regression analyses assessed differences between EM groups regarding exclusion, enrollment and early withdrawal. RESULTS: Of the 10,975 eligible subjects, 6,912 (67%) were invited to participate. EM subjects were more likely to be excluded because of an inability to contact. Of those invited 3,265 (47%) enrolled by the age of 4.5 months. Adjusted analyses showed that except for those classified as other EM, the odds of enrolling were similar across groups. EM subjects had elevated early withdrawal rates. Adjusted models demonstrated that this was significantly more likely among Hispanic subjects. CONCLUSION: Understanding patterns associated with EM participation in research extends our ability to make more accurate inferences and permits assessment of strategies that promote inclusion of EM to better address health disparities.
Authors: William A Hagopian; Henry Erlich; Ake Lernmark; Marian Rewers; Anette G Ziegler; Olli Simell; Beena Akolkar; Robert Vogt; Alan Blair; Jorma Ilonen; Jeffrey Krischer; JinXiong She Journal: Pediatr Diabetes Date: 2011-05-12 Impact factor: 3.409
Authors: Emily K Sims; Susan Geyer; Suzanne Bennett Johnson; Ingrid Libman; Laura M Jacobsen; David Boulware; Lisa E Rafkin; Della Matheson; Mark A Atkinson; Henry Rodriguez; Maria Spall; Helena Elding Larsson; Diane K Wherrett; Carla J Greenbaum; Jeffrey Krischer; Linda A DiMeglio Journal: Diabetes Care Date: 2019-09-26 Impact factor: 19.112
Authors: Kaisa M Kemppainen; Kendra Vehik; Kristian F Lynch; Helena Elding Larsson; Ronald J Canepa; Ville Simell; Sibylle Koletzko; Edwin Liu; Olli G Simell; Jorma Toppari; Anette G Ziegler; Marian J Rewers; Åke Lernmark; William A Hagopian; Jin-Xiong She; Beena Akolkar; Desmond A Schatz; Mark A Atkinson; Martin J Blaser; Jeffrey P Krischer; Heikki Hyöty; Daniel Agardh; Eric W Triplett Journal: JAMA Pediatr Date: 2017-12-01 Impact factor: 16.193