Literature DB >> 22440186

Cohesin, CTCF and lymphocyte antigen receptor locus rearrangement.

Vlad C Seitan1, Michael S Krangel, Matthias Merkenschlager.   

Abstract

The somatic recombination of lymphocyte antigen receptor loci is integral to lymphocyte differentiation and adaptive immunity. Here we review the relation of this highly choreographed process with the zinc finger protein CTCF and with cohesin, a protein complex best known for its essential functions in post-replicative DNA repair and chromosome segregation during the cell cycle. At lymphocyte antigen receptor loci, CTCF and cohesin shape long-range interactions and contribute to V(D)J recombination by facilitating lineage- and developmental-stage-specific transcription and accessibility.
Copyright © 2012 Elsevier Ltd. All rights reserved.

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Year:  2012        PMID: 22440186      PMCID: PMC3352889          DOI: 10.1016/j.it.2012.02.004

Source DB:  PubMed          Journal:  Trends Immunol        ISSN: 1471-4906            Impact factor:   16.687


  30 in total

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