Literature DB >> 20833065

Epigenetic and 3-dimensional regulation of V(D)J rearrangement of immunoglobulin genes.

Stephanie C Degner-Leisso1, Ann J Feeney.   

Abstract

V(D)J recombination is a crucial component of the adaptive immune response, allowing for the production of a diverse antigen receptor repertoire (Ig and TCR). This review will focus on how epigenetic regulation and 3-dimensional (3D) interactions may control V(D)J recombination at Ig loci. The interplay between transcription factors and post-translational modifications at the Igh, Igκ, and Igλ loci will be highlighted. Furthermore, we propose that the spatial organization and epigenetic boundaries of each Ig loci before and during V(D)J recombination may be influenced in part by the CTCF/cohesin complex. Taken together, the many epigenetic and 3D layers of control ensure that Ig loci are only rearranged at appropriate stages of B cell development.
Copyright © 2010 Elsevier Ltd. All rights reserved.

Entities:  

Mesh：

Year:  2010        PMID： 20833065      PMCID： PMC2981695          DOI： 10.1016/j.smim.2010.08.002

Source DB:  PubMed          Journal:  Semin Immunol        ISSN： 1044-5323            Impact factor:   11.130


  52 in total

1.  Individual V(H) promoters vary in strength, but the frequency of rearrangement of those V(H) genes does not correlate with promoter strength nor enhancer-independence.

Authors:  V A Love; G Lugo; D Merz; A J Feeney
Journal:  Mol Immunol       Date:  2000 Jan-Feb       Impact factor: 4.407

2.  V(D)J recombination frequencies can be profoundly affected by changes in the spacer sequence.

Authors:  Alina Montalbano; Kisani M Ogwaro; Alan Tang; Adam G W Matthews; Mani Larijani; Marjorie A Oettinger; Ann J Feeney
Journal:  J Immunol       Date:  2003-11-15       Impact factor: 5.422

3.  Predominant autoantibody production by early human B cell precursors.

Authors:  Hedda Wardemann; Sergey Yurasov; Anne Schaefer; James W Young; Eric Meffre; Michel C Nussenzweig
Journal:  Science       Date:  2003-08-14       Impact factor: 47.728

4.  Stepwise activation of the immunoglobulin mu heavy chain gene locus.

Authors:  D Chowdhury; R Sen
Journal:  EMBO J       Date:  2001-11-15       Impact factor: 11.598

5.  Antigen receptor loci poised for V(D)J rearrangement are broadly associated with BRG1 and flanked by peaks of histone H3 dimethylated at lysine 4.

Authors:  Katrina B Morshead; David N Ciccone; Sean D Taverna; C David Allis; Marjorie A Oettinger
Journal:  Proc Natl Acad Sci U S A       Date:  2003-09-19       Impact factor: 11.205

6.  Cohesin mediates transcriptional insulation by CCCTC-binding factor.

Authors:  Kerstin S Wendt; Keisuke Yoshida; Takehiko Itoh; Masashige Bando; Birgit Koch; Erika Schirghuber; Shuichi Tsutsumi; Genta Nagae; Ko Ishihara; Tsuyoshi Mishiro; Kazuhide Yahata; Fumio Imamoto; Hiroyuki Aburatani; Mitsuyoshi Nakao; Naoko Imamoto; Kazuhiro Maeshima; Katsuhiko Shirahige; Jan-Michael Peters
Journal:  Nature       Date:  2008-01-30       Impact factor: 49.962

7.  Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement.

Authors:  I-Hsin Su; Ashwin Basavaraj; Andrew N Krutchinsky; Oliver Hobert; Axel Ullrich; Brian T Chait; Alexander Tarakhovsky
Journal:  Nat Immunol       Date:  2002-12-23       Impact factor: 25.606

8.  Pax5 is required for recombination of transcribed, acetylated, 5' IgH V gene segments.

Authors:  David G T Hesslein; David L Pflugh; Dipanjan Chowdhury; Alfred L M Bothwell; Ranjan Sen; David G Schatz
Journal:  Genes Dev       Date:  2003-01-01       Impact factor: 11.361

9.  Localized gene-specific induction of accessibility to V(D)J recombination induced by E2A and early B cell factor in nonlymphoid cells.

Authors:  P Goebel; N Janney; J R Valenzuela; W J Romanow; C Murre; A J Feeney
Journal:  J Exp Med       Date:  2001-09-03       Impact factor: 14.307

10.  Ordered rearrangement of immunoglobulin heavy chain variable region segments.

Authors:  F W Alt; G D Yancopoulos; T K Blackwell; C Wood; E Thomas; M Boss; R Coffman; N Rosenberg; S Tonegawa; D Baltimore
Journal:  EMBO J       Date:  1984-06       Impact factor: 11.598
View more
  26 in total

1.  CTCF-cohesin complex: architect of chromatin structure regulates V(D)J rearrangement.

Authors:  Ann J Feeney; Jiyoti Verma-Gaur
Journal:  Cell Res       Date:  2011-11-22       Impact factor: 25.617

2.  Highly diverse TCRα chain repertoire of pre-immune CD8⁺ T cells reveals new insights in gene recombination.

Authors:  Raphael Genolet; Brian J Stevenson; Laurent Farinelli; Magne Osterås; Immanuel F Luescher
Journal:  EMBO J       Date:  2012-02-28       Impact factor: 11.598

3.  The Igκ gene enhancers, E3' and Ed, are essential for triggering transcription.

Authors:  Xiaorong Zhou; Yougui Xiang; William T Garrard
Journal:  J Immunol       Date:  2010-11-12       Impact factor: 5.422

4.  Skewed primary Igκ repertoire and V-J joining in C57BL/6 mice: implications for recombination accessibility and receptor editing.

Authors:  Miyo Aoki-Ota; Ali Torkamani; Takayuki Ota; Nicholas Schork; David Nemazee
Journal:  J Immunol       Date:  2012-01-27       Impact factor: 5.422

5.  CTCF-binding elements 1 and 2 in the Igh intergenic control region cooperatively regulate V(D)J recombination.

Authors:  Sherry G Lin; Chunguang Guo; Arthur Su; Yu Zhang; Frederick W Alt
Journal:  Proc Natl Acad Sci U S A       Date:  2015-01-26       Impact factor: 11.205

6.  A multifunctional element in the mouse Igκ locus that specifies repertoire and Ig loci subnuclear location.

Authors:  Yougui Xiang; Xiaorong Zhou; Susannah L Hewitt; Jane A Skok; William T Garrard
Journal:  J Immunol       Date:  2011-03-25       Impact factor: 5.422

7.  Targeted chromatin profiling reveals novel enhancers in Ig H and Ig L chain Loci.

Authors:  Alexander V Predeus; Suhasni Gopalakrishnan; Yue Huang; Jun Tang; Ann J Feeney; Eugene M Oltz; Maxim N Artyomov
Journal:  J Immunol       Date:  2013-12-18       Impact factor: 5.422

8.  Germline deletion of Igh 3' regulatory region elements hs 5, 6, 7 (hs5-7) affects B cell-specific regulation, rearrangement, and insulation of the Igh locus.

Authors:  Sabrina A Volpi; Jiyoti Verma-Gaur; Rabih Hassan; Zhongliang Ju; Sergio Roa; Sanjukta Chatterjee; Uwe Werling; Harry Hou; Britta Will; Ulrich Steidl; Matthew Scharff; Winfried Edelman; Ann J Feeney; Barbara K Birshtein
Journal:  J Immunol       Date:  2012-02-17       Impact factor: 5.422

9.  Noncoding transcription within the Igh distal V(H) region at PAIR elements affects the 3D structure of the Igh locus in pro-B cells.

Authors:  Jiyoti Verma-Gaur; Ali Torkamani; Lana Schaffer; Steven R Head; Nicholas J Schork; Ann J Feeney
Journal:  Proc Natl Acad Sci U S A       Date:  2012-10-01       Impact factor: 11.205

Review 10.  Chromatin insulators: a role in nuclear organization and gene expression.

Authors:  Jingping Yang; Victor G Corces
Journal:  Adv Cancer Res       Date:  2011       Impact factor: 6.242
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.