Literature DB >> 22424619

p62: a versatile multitasker takes on cancer.

Jorge Moscat1, Maria T Diaz-Meco.   

Abstract

Since its initial discovery as an atypical protein kinase C (PKC)-interacting protein, p62 has emerged as a crucial molecule in a myriad of cellular functions. This multifunctional role of p62 is explained by its ability to interact with several key components of various signaling mechanisms. Not surprisingly, p62 is required for tumor transformation owing to its roles as a key molecule in nutrient sensing, as a regulator and substrate of autophagy, as an inducer of oxidative detoxifying proteins, and as a modulator of mitotic transit and genomic stability; all crucial events in the control of cell growth and cancer.
Copyright © 2012 Elsevier Ltd. All rights reserved.

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Year:  2012        PMID： 22424619      PMCID： PMC3531712          DOI： 10.1016/j.tibs.2012.02.008

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  71 in total

Review 1.  The role of PML in tumor suppression.

Authors:  Paolo Salomoni; Pier Paolo Pandolfi
Journal:  Cell       Date:  2002-01-25       Impact factor: 41.582

Review 2.  Intercellular junctions and cellular polarity: the PAR-aPKC complex, a conserved core cassette playing fundamental roles in cell polarity.

Authors:  S Ohno
Journal:  Curr Opin Cell Biol       Date:  2001-10       Impact factor: 8.382

Review 3.  Par proteins: partners in polarization.

Authors:  Ian G Macara
Journal:  Curr Biol       Date:  2004-02-17       Impact factor: 10.834

4.  p62 is a key regulator of nutrient sensing in the mTORC1 pathway.

Authors:  Angeles Duran; Ramars Amanchy; Juan F Linares; Jayashree Joshi; Shadi Abu-Baker; Aleksey Porollo; Malene Hansen; Jorge Moscat; Maria T Diaz-Meco
Journal:  Mol Cell       Date:  2011-10-07       Impact factor: 17.970

Review 5.  ROS, stress-activated kinases and stress signaling in cancer.

Authors:  Moran Benhar; David Engelberg; Alexander Levitzki
Journal:  EMBO Rep       Date:  2002-05       Impact factor: 8.807

6.  Recurrent mutation of the gene encoding sequestosome 1 (SQSTM1/p62) in Paget disease of bone.

Authors:  Nancy Laurin; Jacques P Brown; Jean Morissette; Vincent Raymond
Journal:  Am J Hum Genet       Date:  2002-04-30       Impact factor: 11.025

7.  Midbody accumulation through evasion of autophagy contributes to cellular reprogramming and tumorigenicity.

Authors:  Tse-Chun Kuo; Chun-Ting Chen; Desiree Baron; Tamer T Onder; Sabine Loewer; Sandra Almeida; Cara M Weismann; Ping Xu; Jean-Marie Houghton; Fen-Biao Gao; George Q Daley; Stephen Doxsey
Journal:  Nat Cell Biol       Date:  2011-09-11       Impact factor: 28.824

8.  Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor.

Authors:  Zhenyu Yue; Shengkan Jin; Chingwen Yang; Arnold J Levine; Nathaniel Heintz
Journal:  Proc Natl Acad Sci U S A       Date:  2003-12-01       Impact factor: 11.205

9.  The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis.

Authors:  Angeles Durán; Manuel Serrano; Michael Leitges; Juana M Flores; Sylvain Picard; Jacques P Brown; Jorge Moscat; Maria T Diaz-Meco
Journal:  Dev Cell       Date:  2004-02       Impact factor: 12.270

10.  mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery.

Authors:  Do-Hyung Kim; D D Sarbassov; Siraj M Ali; Jessie E King; Robert R Latek; Hediye Erdjument-Bromage; Paul Tempst; David M Sabatini
Journal:  Cell       Date:  2002-07-26       Impact factor: 41.582
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  122 in total

Review 1.  Autophagy, Metabolism, and Cancer.

Authors:  Eileen White; Janice M Mehnert; Chang S Chan
Journal:  Clin Cancer Res       Date:  2015-11-15       Impact factor: 12.531

2.  The Implications of the Sequestosome 1 Mutation P392L in Patients with Paget's Disease in a United States Cohort.

Authors:  Margaret Seton; Marc Hansen; Daniel H Solomon
Journal:  Calcif Tissue Int       Date:  2015-12-28       Impact factor: 4.333

3.  Enhanced epithelial-to-mesenchymal transition associated with lysosome dysfunction in podocytes: role of p62/Sequestosome 1 as a signaling hub.

Authors:  Guangbi Li; Cai-Xia Li; Min Xia; Joseph K Ritter; Todd W B Gehr; Krishna Boini; Pin-Lan Li
Journal:  Cell Physiol Biochem       Date:  2015-03-26

Review 4.  Deconvoluting the context-dependent role for autophagy in cancer.

Authors:  Eileen White
Journal:  Nat Rev Cancer       Date:  2012-04-26       Impact factor: 60.716

5.  Autophagy and mTORC1 regulate the stochastic phase of somatic cell reprogramming.

Authors:  Yasong Wu; Yuan Li; Hui Zhang; Yinghua Huang; Ping Zhao; Yujia Tang; Xiaohui Qiu; Yue Ying; Wen Li; Su Ni; Meng Zhang; Longqi Liu; Yan Xu; Qiang Zhuang; Zhiwei Luo; Christina Benda; Hong Song; Baohua Liu; Liangxue Lai; Xingguo Liu; Hung-Fat Tse; Xichen Bao; Wai-Yee Chan; Miguel A Esteban; Baoming Qin; Duanqing Pei
Journal:  Nat Cell Biol       Date:  2015-05-18       Impact factor: 28.824

Review 6.  Oxidative stress response and Nrf2 signaling in aging.

Authors:  Hongqiao Zhang; Kelvin J A Davies; Henry Jay Forman
Journal:  Free Radic Biol Med       Date:  2015-06-09       Impact factor: 7.376

7.  p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis.

Authors:  Hilaire C Lam; Christian V Baglini; Alicia Llorente Lope; Andrey A Parkhitko; Heng-Jia Liu; Nicola Alesi; Izabela A Malinowska; Darius Ebrahimi-Fakhari; Afshin Saffari; Jane J Yu; Ana Pereira; Damir Khabibullin; Barbara Ogorek; Julie Nijmeh; Taylor Kavanagh; Adam Handen; Stephen Y Chan; John M Asara; William M Oldham; Maria T Diaz-Meco; Jorge Moscat; Mustafa Sahin; Carmen Priolo; Elizabeth P Henske
Journal:  Cancer Res       Date:  2017-05-16       Impact factor: 12.701

8.  Selective autophagy: xenophagy.

Authors:  Kyle A Bauckman; Nana Owusu-Boaitey; Indira U Mysorekar
Journal:  Methods       Date:  2014-12-11       Impact factor: 3.608

9.  Tumor suppressor gene PDCD4 negatively regulates autophagy by inhibiting the expression of autophagy-related gene ATG5.

Authors:  Xingguo Song; Xia Zhang; Xiaoyan Wang; Faliang Zhu; Chun Guo; Qun Wang; Yongyu Shi; Jianing Wang; Youhai Chen; Lining Zhang
Journal:  Autophagy       Date:  2013-03-13       Impact factor: 16.016

10.  YY1-MIR372-SQSTM1 regulatory axis in autophagy.

Authors:  Lifeng Feng; Yanning Ma; Jie Sun; Qi Shen; Leiming Liu; Haiqi Lu; Faliang Wang; Yongfang Yue; Jiaqiu Li; Shenjie Zhang; Xiaoying Lin; Jue Chu; Weidong Han; Xian Wang; Hongchuan Jin
Journal:  Autophagy       Date:  2014-06-11       Impact factor: 16.016
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