Literature DB >> 11544035

Intercellular junctions and cellular polarity: the PAR-aPKC complex, a conserved core cassette playing fundamental roles in cell polarity.

S Ohno1.   

Abstract

Two PDZ-domain-containing adapter-like proteins, PAR-3 and PAR-6, and a protein kinase, atypical protein kinase C (PKC), cooperate together to establish cell polarity in a variety of biological contexts. These include asymmetric cell division in early Caenorhabditis elegans embryo and Drosophila neuroblasts, as well as the establishment and maintenance of apical-basal polarity in Drosophila and mammalian epithelial cells. Recent studies on the role of this PAR-aPKC complex in epithelial cell polarization provide new insights into the molecular basis of epithelial junctional formation and cell polarity.

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Year:  2001        PMID： 11544035     DOI： 10.1016/s0955-0674(00)00264-7

Source DB:  PubMed          Journal:  Curr Opin Cell Biol        ISSN： 0955-0674            Impact factor:   8.382


  125 in total

1.  Structure of Cdc42 in a complex with the GTPase-binding domain of the cell polarity protein, Par6.

Authors:  Sarah M Garrard; Christopher T Capaldo; Lin Gao; Michael K Rosen; Ian G Macara; Diana R Tomchick
Journal:  EMBO J       Date:  2003-03-03       Impact factor: 11.598

2.  A novel role of nectins in inhibition of the E-cadherin-induced activation of Rac and formation of cell-cell adherens junctions.

Authors:  Takashi Hoshino; Kazuya Shimizu; Tomoyuki Honda; Tomomi Kawakatsu; Taihei Fukuyama; Takeshi Nakamura; Michiyuki Matsuda; Yoshimi Takai
Journal:  Mol Biol Cell       Date:  2003-12-29       Impact factor: 4.138

3.  The PB1 domain and the PC motif-containing region are structurally similar protein binding modules.

Authors:  Sosuke Yoshinaga; Motoyuki Kohjima; Kenji Ogura; Masashi Yokochi; Ryu Takeya; Takashi Ito; Hideki Sumimoto; Fuyuhiko Inagaki
Journal:  EMBO J       Date:  2003-10-01       Impact factor: 11.598

4.  EFA6, exchange factor for ARF6, regulates the actin cytoskeleton and associated tight junction in response to E-cadherin engagement.

Authors:  Frédéric Luton; Stéphanie Klein; Jean-Paul Chauvin; André Le Bivic; Sylvain Bourgoin; Michel Franco; Pierre Chardin
Journal:  Mol Biol Cell       Date:  2003-12-10       Impact factor: 4.138

5.  A genomewide survey of developmentally relevant genes in Ciona intestinalis. VII. Molecules involved in the regulation of cell polarity and actin dynamics.

Authors:  Yasunori Sasakura; Lixy Yamada; Naohito Takatori; Yutaka Satou; Nori Satoh
Journal:  Dev Genes Evol       Date:  2003-05-10       Impact factor: 0.900

6.  Loss of PALS1 expression leads to tight junction and polarity defects.

Authors:  Samuel W Straight; Kunyoo Shin; Vanessa C Fogg; Shuling Fan; Chia-Jen Liu; Michael Roh; Ben Margolis
Journal:  Mol Biol Cell       Date:  2004-01-12       Impact factor: 4.138

Review 7.  Regulation of endocytic traffic by Rho GTPases.

Authors:  Britta Qualmann; Harry Mellor
Journal:  Biochem J       Date:  2003-04-15       Impact factor: 3.857

Review 8.  Protein kinase C iota: human oncogene, prognostic marker and therapeutic target.

Authors:  Alan P Fields; Roderick P Regala
Journal:  Pharmacol Res       Date:  2007-05-05       Impact factor: 7.658

9.  PAR1 specifies ciliated cells in vertebrate ectoderm downstream of aPKC.

Authors:  Olga Ossipova; Jacqui Tabler; Jeremy B A Green; Sergei Y Sokol
Journal:  Development       Date:  2007-12       Impact factor: 6.868

10.  PKClambda in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity.

Authors:  Michihiro Matsumoto; Wataru Ogawa; Kazunori Akimoto; Hiroshi Inoue; Kazuaki Miyake; Kensuke Furukawa; Yoshitake Hayashi; Haruhisa Iguchi; Yasushi Matsuki; Ryuji Hiramatsu; Hitoshi Shimano; Nobuhiro Yamada; Shigeo Ohno; Masato Kasuga; Tetsuo Noda
Journal:  J Clin Invest       Date:  2003-09       Impact factor: 14.808
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