Literature DB >> 15027470

Par proteins: partners in polarization.

Ian G Macara1.   

Abstract

Proteins can be localized either by inclusion or exclusion, and the Par polarity proteins illustrate both mechanisms. Cdc42 recruits Par-6 to a limited region of the plasma membrane. Par-6 recruits Par-3, which is actively removed from other regions by Par-1 and Par-5. Inclusion and exclusion together ensure efficient segregation of the polarity proteins.

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Year:  2004        PMID： 15027470

Source DB:  PubMed          Journal:  Curr Biol        ISSN： 0960-9822            Impact factor:   10.834


  52 in total

Review 1.  Tips, stalks, tubes: notch-mediated cell fate determination and mechanisms of tubulogenesis during angiogenesis.

Authors:  Jennifer J Tung; Ian W Tattersall; Jan Kitajewski
Journal:  Cold Spring Harb Perspect Med       Date:  2012-02       Impact factor: 6.915

2.  A unified assembly mode revealed by the structures of tetrameric L27 domain complexes formed by mLin-2/mLin-7 and Patj/Pals1 scaffold proteins.

Authors:  Wei Feng; Jia-Fu Long; Mingjie Zhang
Journal:  Proc Natl Acad Sci U S A       Date:  2005-04-29       Impact factor: 11.205

3.  PAK5 kinase is an inhibitor of MARK/Par-1, which leads to stable microtubules and dynamic actin.

Authors:  Dorthe Matenia; Bettina Griesshaber; Xiao-yu Li; Anja Thiessen; Cindy Johne; Jian Jiao; Eckhard Mandelkow; Eva-Maria Mandelkow
Journal:  Mol Biol Cell       Date:  2005-07-12       Impact factor: 4.138

4.  Stabilization of cell polarity by the C. elegans RING protein PAR-2.

Authors:  Yingsong Hao; Lynn Boyd; Geraldine Seydoux
Journal:  Dev Cell       Date:  2006-02       Impact factor: 12.270

Review 5.  PARtitioning numb.

Authors:  James E Casanova
Journal:  EMBO Rep       Date:  2007-03       Impact factor: 8.807

6.  The Par-3 NTD adopts a PB1-like structure required for Par-3 oligomerization and membrane localization.

Authors:  Wei Feng; Hao Wu; Ling-Nga Chan; Mingjie Zhang
Journal:  EMBO J       Date:  2007-05-03       Impact factor: 11.598

Review 7.  Epithelial junctions and polarity: complexes and kinases.

Authors:  Michael J Caplan; Patricia Seo-Mayer; Li Zhang
Journal:  Curr Opin Nephrol Hypertens       Date:  2008-09       Impact factor: 2.894

8.  Loss of podocyte aPKClambda/iota causes polarity defects and nephrotic syndrome.

Authors:  Tobias B Huber; Björn Hartleben; Kirstin Winkelmann; Lisa Schneider; Jan U Becker; Michael Leitges; Gerd Walz; Hermann Haller; Mario Schiffer
Journal:  J Am Soc Nephrol       Date:  2009-03-11       Impact factor: 10.121

9.  Neph-Nephrin proteins bind the Par3-Par6-atypical protein kinase C (aPKC) complex to regulate podocyte cell polarity.

Authors:  Björn Hartleben; Heiko Schweizer; Pauline Lübben; Malte P Bartram; Clemens C Möller; Ronja Herr; Changli Wei; Elke Neumann-Haefelin; Bernhard Schermer; Hanswalter Zentgraf; Dontscho Kerjaschki; Jochen Reiser; Gerd Walz; Thomas Benzing; Tobias B Huber
Journal:  J Biol Chem       Date:  2008-06-18       Impact factor: 5.157

10.  Eya1 controls cell polarity, spindle orientation, cell fate and Notch signaling in distal embryonic lung epithelium.

Authors:  Ahmed H K El-Hashash; Gianluca Turcatel; Denise Al Alam; Sue Buckley; Hiroshi Tokumitsu; Saverio Bellusci; David Warburton
Journal:  Development       Date:  2011-04       Impact factor: 6.868
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