Literature DB >> 26066302

Oxidative stress response and Nrf2 signaling in aging.

Hongqiao Zhang1, Kelvin J A Davies2, Henry Jay Forman3.   

Abstract

Increasing oxidative stress, a major characteristic of aging, has been implicated in a variety of age-related pathologies. In aging, oxidant production from several sources is increased, whereas antioxidant enzymes, the primary lines of defense, are decreased. Repair systems, including the proteasomal degradation of damaged proteins, also decline. Importantly, the adaptive response to oxidative stress declines with aging. Nrf2/EpRE signaling regulates the basal and inducible expression of many antioxidant enzymes and the proteasome. Nrf2/EpRE activity is regulated at several levels, including transcription, posttranslation, and interactions with other proteins. This review summarizes current studies on age-related impairment of Nrf2/EpRE function and discusses the changes in Nrf2 regulatory mechanisms with aging.
Copyright © 2015 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Aging; Antioxidant; Free radicals; Nrf2; Oxidative stress; Transcription factor

Mesh：

Substances：

Year:  2015        PMID： 26066302      PMCID： PMC4628850          DOI： 10.1016/j.freeradbiomed.2015.05.036

Source DB:  PubMed          Journal:  Free Radic Biol Med        ISSN： 0891-5849            Impact factor:   7.376


  414 in total

1.  Age-related death-survival balance in myocardium: an immunohistochemical and biochemical study.

Authors:  Lucia Centurione; Adriano Antonucci; Sebastiano Miscia; Alfredo Grilli; Monica Rapino; Giovanna Grifone; Viviana Di Giacomo; Camillo Di Giulio; Mirella Falconi; Amelia Cataldi
Journal:  Mech Ageing Dev       Date:  2002-02       Impact factor: 5.432

Review 2.  Relationship between antioxidants, prooxidants, and the aging process.

Authors:  R S Sohal; W C Orr
Journal:  Ann N Y Acad Sci       Date:  1992-11-21       Impact factor: 5.691

Review 3.  ER and aging-Protein folding and the ER stress response.

Authors:  Nirinjini Naidoo
Journal:  Ageing Res Rev       Date:  2009-03-21       Impact factor: 10.895

4.  Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription.

Authors:  Y Katoh; K Itoh; E Yoshida; M Miyagishi; A Fukamizu; M Yamamoto
Journal:  Genes Cells       Date:  2001-10       Impact factor: 1.891

Review 5.  Role of redox-regulated transcription factors in inflammation, aging and age-related diseases.

Authors:  Y Lavrovsky; B Chatterjee; R A Clark; A K Roy
Journal:  Exp Gerontol       Date:  2000-08       Impact factor: 4.032

Review 6.  Mitochondrial free radical generation, oxidative stress, and aging.

Authors:  E Cadenas; K J Davies
Journal:  Free Radic Biol Med       Date:  2000-08       Impact factor: 7.376

Review 7.  Nrf2 signaling in coordinated activation of antioxidant gene expression.

Authors:  Anil K Jaiswal
Journal:  Free Radic Biol Med       Date:  2004-05-15       Impact factor: 7.376

8.  Age-dependent basal level and induction capacity of copper-zinc and manganese superoxide dismutase and other scavenging enzyme activities in leukocytes from young and elderly adults.

Authors:  Y Niwa; O Iizawa; K Ishimoto; H Akamatsu; T Kanoh
Journal:  Am J Pathol       Date:  1993-07       Impact factor: 4.307

9.  Impaired transcriptional activity of Nrf2 in age-related myocardial oxidative stress is reversible by moderate exercise training.

Authors:  Sellamuthu S Gounder; Sankaranarayanan Kannan; Dinesh Devadoss; Corey J Miller; Kevin J Whitehead; Kevin S Whitehead; Shannon J Odelberg; Matthew A Firpo; Robert Paine; John R Hoidal; E Dale Abel; Namakkal S Rajasekaran
Journal:  PLoS One       Date:  2012-09-24       Impact factor: 3.240

10.  BRCA1 may modulate neuronal cell cycle re-entry in Alzheimer disease.

Authors:  Teresa A Evans; Arun K Raina; André Delacourte; Olga Aprelikova; Hyoung-gon Lee; Xiongwei Zhu; George Perry; Mark A Smith
Journal:  Int J Med Sci       Date:  2007-05-12       Impact factor: 3.738
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  210 in total

Review 1.  The Proteasome and Oxidative Stress in Alzheimer's Disease.

Authors:  Vicent Bonet-Costa; Laura Corrales-Diaz Pomatto; Kelvin J A Davies
Journal:  Antioxid Redox Signal       Date:  2016-08-25       Impact factor: 8.401

Review 2.  The Role of Nrf2 in the Response to Normal Tissue Radiation Injury.

Authors:  Brent D Cameron; Konjeti R Sekhar; Maxwell Ofori; Michael L Freeman
Journal:  Radiat Res       Date:  2018-05-25       Impact factor: 2.841

3.  Gartanin Protects Neurons against Glutamate-Induced Cell Death in HT22 Cells: Independence of Nrf-2 but Involvement of HO-1 and AMPK.

Authors:  Xiao-Yun Gao; Sheng-Nan Wang; Xiao-Hong Yang; Wen-Jian Lan; Zi-Wei Chen; Jing-Kao Chen; Jian-Hui Xie; Yi-Fan Han; Rong-Biao Pi; Xiao-Bo Yang
Journal:  Neurochem Res       Date:  2016-05-09       Impact factor: 3.996

Review 4.  Supraphysiologic-dose anabolic-androgenic steroid use: A risk factor for dementia?

Authors:  Marc J Kaufman; Gen Kanayama; James I Hudson; Harrison G Pope
Journal:  Neurosci Biobehav Rev       Date:  2019-02-25       Impact factor: 8.989

Review 5.  Mitohormesis and metabolic health: The interplay between ROS, cAMP and sirtuins.

Authors:  Carlos Marques Palmeira; João Soeiro Teodoro; João Alves Amorim; Clemens Steegborn; David A Sinclair; Anabela Pinto Rolo
Journal:  Free Radic Biol Med       Date:  2019-07-24       Impact factor: 7.376

Review 6.  Sulforaphane - role in aging and neurodegeneration.

Authors:  Roberto Santín-Márquez; Adriana Alarcón-Aguilar; Norma Edith López-Diazguerrero; Niki Chondrogianni; Mina Königsberg
Journal:  Geroscience       Date:  2019-04-02       Impact factor: 7.713

7.  Constitutive Activation of NAD-Dependent Sirtuin 3 Plays an Important Role in Tumorigenesis of Chromium(VI)-Transformed Cells.

Authors:  Marco Clementino; Donghern Kim; Zhuo Zhang
Journal:  Toxicol Sci       Date:  2019-05-01       Impact factor: 4.849

Review 8.  4-hydroxynonenal-mediated signaling and aging.

Authors:  Hongqiao Zhang; Henry Jay Forman
Journal:  Free Radic Biol Med       Date:  2016-11-20       Impact factor: 7.376

9.  Curcumin revitalizes Amyloid beta (25-35)-induced and organophosphate pesticides pestered neurotoxicity in SH-SY5Y and IMR-32 cells via activation of APE1 and Nrf2.

Authors:  Bibekananda Sarkar; Monisha Dhiman; Sunil Mittal; Anil K Mantha
Journal:  Metab Brain Dis       Date:  2017-08-31       Impact factor: 3.584

Review 10.  Nrf2-a Promising Therapeutic Target for Defensing Against Oxidative Stress in Stroke.

Authors:  Rongrong Zhang; Mengxue Xu; Yu Wang; Fei Xie; Gang Zhang; Xinyue Qin
Journal:  Mol Neurobiol       Date:  2016-09-30       Impact factor: 5.590
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