Literature DB >> 22238143

IspG-catalyzed positional isotopic exchange in methylerythritol cyclodiphosphate of the deoxyxylulose phosphate pathway: mechanistic implications.

Youli Xiao1, Debra Rooker, Quincy You, Caren L Freel Meyers, Pinghua Liu.   

Abstract

H(2)(18)O under the bridge: Recently, the deoxyxylulose phosphate (DXP) pathway was discovered to be a second pathway supplying isoprenoid biosynthetic precursors. One of steps is an IspG-catalyzed reductive deoxygenation of methylerythritol cyclodiphosphate (MEcPP) to 4-hydroxyl-3-methyl-2-(E)-1-diphosphate (HMBPP). Using [2-(13) C,(18) O]-MEcPP, we detected the positional isotopic exchange for the bridging oxygen in MEcPP.
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2011        PMID： 22238143      PMCID： PMC3257810          DOI： 10.1002/cbic.201000716

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


  23 in total

1.  Organometallic mechanism of action and inhibition of the 4Fe-4S isoprenoid biosynthesis protein GcpE (IspG).

Authors:  Weixue Wang; Jikun Li; Ke Wang; Cancan Huang; Yong Zhang; Eric Oldfield
Journal:  Proc Natl Acad Sci U S A       Date:  2010-06-07       Impact factor: 11.205

2.  Studies on the nonmevalonate pathway to terpenes: the role of the GcpE (IspG) protein.

Authors:  S Hecht; W Eisenreich; P Adam; S Amslinger; K Kis; A Bacher; D Arigoni; F Rohdich
Journal:  Proc Natl Acad Sci U S A       Date:  2001-12-18       Impact factor: 11.205

3.  IspG enzyme activity in the deoxyxylulose phosphate pathway: roles of the iron-sulfur cluster.

Authors:  Youli Xiao; Georgia Zahariou; Yiannis Sanakis; Pinghua Liu
Journal:  Biochemistry       Date:  2009-11-10       Impact factor: 3.162

4.  Identification of gcpE as a novel gene of the 2-C-methyl-D-erythritol 4-phosphate pathway for isoprenoid biosynthesis in Escherichia coli.

Authors:  N Campos; M Rodríguez-Concepción; M Seemann; M Rohmer; A Boronat
Journal:  FEBS Lett       Date:  2001-01-19       Impact factor: 4.124

Review 5.  The non-mevalonate pathway of isoprenoids: genes, enzymes and intermediates.

Authors:  F Rohdich; K Kis; A Bacher; W Eisenreich
Journal:  Curr Opin Chem Biol       Date:  2001-10       Impact factor: 8.822

6.  Biosynthesis of isoprenoids: crystal structure of the [4Fe-4S] cluster protein IspG.

Authors:  Matthias Lee; Tobias Gräwert; Felix Quitterer; Felix Rohdich; Jörg Eppinger; Wolfgang Eisenreich; Adelbert Bacher; Michael Groll
Journal:  J Mol Biol       Date:  2010-10-07       Impact factor: 5.469

Review 7.  Formation of unusual sugars: mechanistic studies and biosynthetic applications.

Authors:  Xuemei M He; Hung-Wen Liu
Journal:  Annu Rev Biochem       Date:  2001-11-09       Impact factor: 23.643

8.  Functional analysis of the Arabidopsis thaliana GCPE protein involved in plastid isoprenoid biosynthesis.

Authors:  Jordi Querol; Narciso Campos; Santiago Imperial; Albert Boronat; Manuel Rodríguez-Concepción
Journal:  FEBS Lett       Date:  2002-03-13       Impact factor: 4.124

9.  Methylerythritol cyclodiphosphate (MEcPP) in deoxyxylulose phosphate pathway: synthesis from an epoxide and mechanisms.

Authors:  Youli Xiao; Rodney L Nyland; Caren L Freel Meyers; Pinghua Liu
Journal:  Chem Commun (Camb)       Date:  2010-09-01       Impact factor: 6.222

10.  IspG converts an epoxide substrate analogue to (E)-4-hydroxy-3-methylbut-2-enyl diphosphate: implications for IspG catalysis in isoprenoid biosynthesis.

Authors:  Rodney L Nyland; Youli Xiao; Pinghua Liu; Caren L Freel Meyers
Journal:  J Am Chem Soc       Date:  2009-12-16       Impact factor: 15.419
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  5 in total

Review 1.  Terpene biosynthesis: modularity rules.

Authors:  Eric Oldfield; Fu-Yang Lin
Journal:  Angew Chem Int Ed Engl       Date:  2011-11-21       Impact factor: 15.336

2.  Atomic-Resolution Structures of Discrete Stages on the Reaction Coordinate of the [Fe4S4] Enzyme IspG (GcpE).

Authors:  Felix Quitterer; Annika Frank; Ke Wang; Guodong Rao; Bing O'Dowd; Jikun Li; Francisco Guerra; Safwat Abdel-Azeim; Adelbert Bacher; Jörg Eppinger; Eric Oldfield; Michael Groll
Journal:  J Mol Biol       Date:  2015-04-11       Impact factor: 5.469

Review 3.  Bioorganometallic chemistry with IspG and IspH: structure, function, and inhibition of the [Fe(4)S(4)] proteins involved in isoprenoid biosynthesis.

Authors:  Weixue Wang; Eric Oldfield
Journal:  Angew Chem Int Ed Engl       Date:  2014-01-31       Impact factor: 15.336

Review 4.  Methylerythritol phosphate pathway of isoprenoid biosynthesis.

Authors:  Lishan Zhao; Wei-chen Chang; Youli Xiao; Hung-wen Liu; Pinghua Liu
Journal:  Annu Rev Biochem       Date:  2013       Impact factor: 23.643

Review 5.  Current development in isoprenoid precursor biosynthesis and regulation.

Authors:  Wei-chen Chang; Heng Song; Hung-wen Liu; Pinghua Liu
Journal:  Curr Opin Chem Biol       Date:  2013-07-24       Impact factor: 8.822
  5 in total

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