Literature DB >> 20820543

Methylerythritol cyclodiphosphate (MEcPP) in deoxyxylulose phosphate pathway: synthesis from an epoxide and mechanisms.

Youli Xiao1, Rodney L Nyland, Caren L Freel Meyers, Pinghua Liu.   

Abstract

In this communication, we reported another unique IspG-catalyzed transformation, the production of its substrate, MEcPP, from (2R,3R)-4-hydroxy-3-methyl-2,3-epoxybutanyl diphosphate (Epoxy-HMBPP) when reductants are excluded from the reaction mixture.

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Year:  2010        PMID： 20820543      PMCID： PMC3170881          DOI： 10.1039/c0cc02594a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  22 in total

1.  Enzymology, structure, and dynamics of acetohydroxy acid isomeroreductase.

Authors:  R Dumas; V Biou; F Halgand; R Douce; R G Duggleby
Journal:  Acc Chem Res       Date:  2001-05       Impact factor: 22.384

2.  Isoprenoid biosynthesis through the methylerythritol phosphate pathway: the (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase (GcpE) is a [4Fe-4S] protein.

Authors:  Myriam Seemann; Bernadette Tse Sum Bui; Murielle Wolff; Denis Tritsch; Narciso Campos; Albert Boronat; Andrée Marquet; Michel Rohmer
Journal:  Angew Chem Int Ed Engl       Date:  2002-11-15       Impact factor: 15.336

3.  Studies on the nonmevalonate pathway to terpenes: the role of the GcpE (IspG) protein.

Authors:  S Hecht; W Eisenreich; P Adam; S Amslinger; K Kis; A Bacher; D Arigoni; F Rohdich
Journal:  Proc Natl Acad Sci U S A       Date:  2001-12-18       Impact factor: 11.205

4.  Functional characterization of GcpE, an essential enzyme of the non-mevalonate pathway of isoprenoid biosynthesis.

Authors:  Ann-Kristin Kollas; Evert C Duin; Matthias Eberl; Boran Altincicek; Martin Hintz; Armin Reichenberg; Dajana Henschker; Anke Henne; Irina Steinbrecher; Dmitry N Ostrovsky; Reiner Hedderich; Ewald Beck; Hassan Jomaa; Jochen Wiesner
Journal:  FEBS Lett       Date:  2002-12-18       Impact factor: 4.124

5.  Identification of gcpE as a novel gene of the 2-C-methyl-D-erythritol 4-phosphate pathway for isoprenoid biosynthesis in Escherichia coli.

Authors:  N Campos; M Rodríguez-Concepción; M Seemann; M Rohmer; A Boronat
Journal:  FEBS Lett       Date:  2001-01-19       Impact factor: 4.124

Review 6.  The non-mevalonate pathway of isoprenoids: genes, enzymes and intermediates.

Authors:  F Rohdich; K Kis; A Bacher; W Eisenreich
Journal:  Curr Opin Chem Biol       Date:  2001-10       Impact factor: 8.822

Review 7.  Formation of unusual sugars: mechanistic studies and biosynthetic applications.

Authors:  Xuemei M He; Hung-Wen Liu
Journal:  Annu Rev Biochem       Date:  2001-11-09       Impact factor: 23.643

8.  Functional analysis of the Arabidopsis thaliana GCPE protein involved in plastid isoprenoid biosynthesis.

Authors:  Jordi Querol; Narciso Campos; Santiago Imperial; Albert Boronat; Manuel Rodríguez-Concepción
Journal:  FEBS Lett       Date:  2002-03-13       Impact factor: 4.124

9.  E. coli MEP synthase: steady-state kinetic analysis and substrate binding.

Authors:  Andrew T Koppisch; David T Fox; Brian S J Blagg; C D Poulter
Journal:  Biochemistry       Date:  2002-01-08       Impact factor: 3.162

10.  Isoprenoid biosynthesis via the methylerythritol phosphate pathway. Mechanistic investigations of the 1-deoxy-D-xylulose 5-phosphate reductoisomerase.

Authors:  Jean-François Hoeffler; Denis Tritsch; Catherine Grosdemange-Billiard; Michel Rohmer
Journal:  Eur J Biochem       Date:  2002-09
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  9 in total

1.  An ENDOR and HYSCORE investigation of a reaction intermediate in IspG (GcpE) catalysis.

Authors:  Weixue Wang; Ke Wang; Jikun Li; Saritha Nellutla; Tatyana I Smirnova; Eric Oldfield
Journal:  J Am Chem Soc       Date:  2011-05-16       Impact factor: 15.419

Review 2.  Terpene biosynthesis: modularity rules.

Authors:  Eric Oldfield; Fu-Yang Lin
Journal:  Angew Chem Int Ed Engl       Date:  2011-11-21       Impact factor: 15.336

Review 3.  Biochemistry of the non-mevalonate isoprenoid pathway.

Authors:  Tobias Gräwert; Michael Groll; Felix Rohdich; Adelbert Bacher; Wolfgang Eisenreich
Journal:  Cell Mol Life Sci       Date:  2011-07-09       Impact factor: 9.261

4.  Atomic-Resolution Structures of Discrete Stages on the Reaction Coordinate of the [Fe4S4] Enzyme IspG (GcpE).

Authors:  Felix Quitterer; Annika Frank; Ke Wang; Guodong Rao; Bing O'Dowd; Jikun Li; Francisco Guerra; Safwat Abdel-Azeim; Adelbert Bacher; Jörg Eppinger; Eric Oldfield; Michael Groll
Journal:  J Mol Biol       Date:  2015-04-11       Impact factor: 5.469

Review 5.  Bioorganometallic chemistry with IspG and IspH: structure, function, and inhibition of the [Fe(4)S(4)] proteins involved in isoprenoid biosynthesis.

Authors:  Weixue Wang; Eric Oldfield
Journal:  Angew Chem Int Ed Engl       Date:  2014-01-31       Impact factor: 15.336

Review 6.  Methylerythritol phosphate pathway of isoprenoid biosynthesis.

Authors:  Lishan Zhao; Wei-chen Chang; Youli Xiao; Hung-wen Liu; Pinghua Liu
Journal:  Annu Rev Biochem       Date:  2013       Impact factor: 23.643

7.  IspG-catalyzed positional isotopic exchange in methylerythritol cyclodiphosphate of the deoxyxylulose phosphate pathway: mechanistic implications.

Authors:  Youli Xiao; Debra Rooker; Quincy You; Caren L Freel Meyers; Pinghua Liu
Journal:  Chembiochem       Date:  2011-01-26       Impact factor: 3.164

Review 8.  Current development in isoprenoid precursor biosynthesis and regulation.

Authors:  Wei-chen Chang; Heng Song; Hung-wen Liu; Pinghua Liu
Journal:  Curr Opin Chem Biol       Date:  2013-07-24       Impact factor: 8.822

9.  Metabolite profiling identified methylerythritol cyclodiphosphate efflux as a limiting step in microbial isoprenoid production.

Authors:  Kang Zhou; Ruiyang Zou; Gregory Stephanopoulos; Heng-Phon Too
Journal:  PLoS One       Date:  2012-11-02       Impact factor: 3.240
  9 in total

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