Literature DB >> 2217210

Dietary pesticides (99.99% all natural).

B N Ames1, M Profet, L S Gold.   

Abstract

The toxicological significance of exposures to synthetic chemicals is examined in the context of exposures to naturally occurring chemicals. We calculate that 99.99% (by weight) of the pesticides in the American diet are chemicals that plants produce to defend themselves. Only 52 natural pesticides have been tested in high-dose animal cancer tests, and about half (27) are rodent carcinogens; these 27 are shown to be present in many common foods. We conclude that natural and synthetic chemicals are equally likely to be positive in animal cancer tests. We also conclude that at the low doses of most human exposures the comparative hazards of synthetic pesticide residues are insignificant.

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Year:  1990        PMID: 2217210      PMCID: PMC54831          DOI: 10.1073/pnas.87.19.7777

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN: 0027-8424            Impact factor:   11.205


  57 in total

1.  Response: paleolithic diet, evolution, and carcinogens.

Authors:  B N Ames; L S Gold
Journal:  Science       Date:  1987-12-18       Impact factor: 47.728

2.  FDA Total Diet Study, April 1982-April 1984, dietary intakes of pesticides, selected elements, and other chemicals.

Authors:  E L Gunderson
Journal:  J Assoc Off Anal Chem       Date:  1988 Nov-Dec

Review 3.  Mutagens and carcinogens in foods.

Authors:  C Furihata; T Matsushima
Journal:  Annu Rev Nutr       Date:  1986       Impact factor: 11.848

4.  Induction of forestomach lesions in rats by oral administrations of naturally occurring antioxidants for 4 weeks.

Authors:  M Hirose; A Masuda; K Imaida; M Kagawa; H Tsuda; N Ito
Journal:  Jpn J Cancer Res       Date:  1987-04

5.  Structure-activity studies of the carcinogenicities in the mouse and rat of some naturally occurring and synthetic alkenylbenzene derivatives related to safrole and estragole.

Authors:  E C Miller; A B Swanson; D H Phillips; T L Fletcher; A Liem; J A Miller
Journal:  Cancer Res       Date:  1983-03       Impact factor: 12.701

6.  Aortic rupture and aortic smooth muscle tumors in mice. Induction by p-hydrazinobenzoic acid hydrochloride of the cultivated mushroom Agaricus bisporus.

Authors:  B M McManus; B Toth; K D Patil
Journal:  Lab Invest       Date:  1987-07       Impact factor: 5.662

7.  [Diphenols and caramel compounds in roasted coffees of different varieties. II. (author's transl)].

Authors:  R Tressl; D Bahri; H Köppler; A Jensen
Journal:  Z Lebensm Unters Forsch       Date:  1978-08-30

8.  Postlabeling methods for carcinogen-DNA adduct analysis.

Authors:  K Randerath; E Randerath; H P Agrawal; R C Gupta; M E Schurdak; M V Reddy
Journal:  Environ Health Perspect       Date:  1985-10       Impact factor: 9.031

9.  Stomach carcinogenicity of caffeic acid, sesamol and catechol in rats and mice.

Authors:  M Hirose; S Fukushima; T Shirai; R Hasegawa; T Kato; H Tanaka; E Asakawa; N Ito
Journal:  Jpn J Cancer Res       Date:  1990-03

10.  Third chronological supplement to the carcinogenic potency database: standardized results of animal bioassays published through December 1986 and by the National Toxicology Program through June 1987.

Authors:  L S Gold; T H Slone; G M Backman; S Eisenberg; M Da Costa; M Wong; N B Manley; L Rohrbach; B N Ames
Journal:  Environ Health Perspect       Date:  1990-03       Impact factor: 9.031

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  37 in total

Review 1.  [The overall toxic situation today. Thoughts on the WHO report, "Diet, nutrition and the prevention of chronic diseases."].

Authors:  J F Diehl
Journal:  Z Ernahrungswiss       Date:  1992-12

2.  Ames, the Ames test, and the causes of cancer.

Authors:  D Forman
Journal:  BMJ       Date:  1991-08-24

Review 3.  Broccoli sprouts as inducers of carcinogen-detoxifying enzyme systems: clinical, dietary, and policy implications.

Authors:  M Nestle
Journal:  Proc Natl Acad Sci U S A       Date:  1997-10-14       Impact factor: 11.205

Review 4.  Mechanisms of DNA damage, repair, and mutagenesis.

Authors:  Nimrat Chatterjee; Graham C Walker
Journal:  Environ Mol Mutagen       Date:  2017-05-09       Impact factor: 3.216

5.  Editor's choice: Evaluating the potential for adverse interactions within genetically engineered breeding stacks.

Authors:  Henry-York Steiner; Claire Halpin; Joseph M Jez; John Kough; Wayne Parrott; Lynne Underhill; Natalie Weber; L Curtis Hannah
Journal:  Plant Physiol       Date:  2013-03-04       Impact factor: 8.340

6.  A risk-based approach to the regulation of genetically engineered organisms.

Authors:  Gregory Conko; Drew L Kershen; Henry Miller; Wayne A Parrott
Journal:  Nat Biotechnol       Date:  2016-05-06       Impact factor: 54.908

7.  Rapid detection of inducers of enzymes that protect against carcinogens.

Authors:  H J Prochaska; A B Santamaria; P Talalay
Journal:  Proc Natl Acad Sci U S A       Date:  1992-03-15       Impact factor: 11.205

8.  Variation in the gene TAS2R38 is associated with the eating behavior disinhibition in Old Order Amish women.

Authors:  Cedrick D Dotson; Hillary L Shaw; Braxton D Mitchell; Steven D Munger; Nanette I Steinle
Journal:  Appetite       Date:  2009-09-25       Impact factor: 3.868

9.  Characterization of the tobacco glycoprotein surface binding property of heart and skeletal muscle cells. I. Modulation of the heart cell membrane TGP interaction by anti-TGP IgG.

Authors:  C A Santos-Buch; H R Hall; F Farfan; I Orlow; A Firpo; B F von Kreuter; C G Becker
Journal:  Arch Toxicol       Date:  1995       Impact factor: 5.153

10.  Fruit and vegetable intake and risk of breast cancer by hormone receptor status.

Authors:  Seungyoun Jung; Donna Spiegelman; Laura Baglietto; Leslie Bernstein; Deborah A Boggs; Piet A van den Brandt; Julie E Buring; James R Cerhan; Mia M Gaudet; Graham G Giles; Gary Goodman; Niclas Hakansson; Susan E Hankinson; Kathy Helzlsouer; Pamela L Horn-Ross; Manami Inoue; Vittorio Krogh; Marie Lof; Marjorie L McCullough; Anthony B Miller; Marian L Neuhouser; Julie R Palmer; Yikyung Park; Kim Robien; Thomas E Rohan; Stephanie Scarmo; Catherine Schairer; Leo J Schouten; James M Shikany; Sabina Sieri; Schoichiro Tsugane; Kala Visvanathan; Elisabete Weiderpass; Walter C Willett; Alicja Wolk; Anne Zeleniuch-Jacquotte; Shumin M Zhang; Xuehong Zhang; Regina G Ziegler; Stephanie A Smith-Warner
Journal:  J Natl Cancer Inst       Date:  2013-01-24       Impact factor: 13.506

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