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Literature DB >> 2217172

Localization of phosphatidylinositol signaling components in rat taste cells: role in bitter taste transduction.

P M Hwang¹, A Verma, D S Bredt, S H Snyder.

Abstract

To assess the role of phosphatidylinositol turnover in taste transduction we have visualized, in rat tongue, ATP-dependent endoplasmic reticular accumulation of 45Ca2+, inositol 1,4,5-trisphosphate receptor binding sites, and phosphatidylinositol turnover monitored by autoradiography of [3H]cytidine diphosphate diacylglycerol formed from [3H]cytidine. Accumulated 45Ca2+, inositol 1,4,5-trisphosphate receptors, and phosphatidylinositol turnover are selectively localized to apical areas of the taste buds of circumvallate papillae, which are associated with bitter taste. Further evidence for a role of phosphatidylinositol turnover in bitter taste is our observation of a rapid, selective increase in mass levels of inositol 1,4,5-trisphosphate elicited by low concentrations of denatonium, a potently bitter tastant.

Entities: Chemical Disease Species

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Year: 1990 PMID： 2217172 PMCID： PMC54753 DOI： 10.1073/pnas.87.19.7395

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

28 in total

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Journal: Pharmacol Rev Date: 1978-03 Impact factor: 25.468

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Authors: J G Kennedy
Journal: Arch Oral Biol Date: 1972-08 Impact factor: 2.633

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Authors: G L Heck; S Mierson; J A DeSimone
Journal: Science Date: 1984-01-27 Impact factor: 47.728

5. Amiloride reduces the taste intensity of Na+ and Li+ salts and sweeteners.

Authors: S S Schiffman; E Lockhead; F W Maes
Journal: Proc Natl Acad Sci U S A Date: 1983-10 Impact factor: 11.205

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Journal: Biochem J Date: 1982-09-15 Impact factor: 3.857

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Authors: F B Axelrod; N Branom; M Becker; R Nachtigall; J Dancis
Journal: J Pediatr Date: 1972-09 Impact factor: 4.406

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Authors: A SMITH; A FARBMAN; J DANCIS
Journal: Science Date: 1965-02-26 Impact factor: 47.728

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Authors: M J Berridge; R M Dawson; C P Downes; J P Heslop; R F Irvine
Journal: Biochem J Date: 1983-05-15 Impact factor: 3.857

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Authors: A R Hand
Journal: J Cell Biol Date: 1970-02 Impact factor: 10.539

17 in total

1. Activation by bitter substances of a cationic channel in membrane patches excised from the bullfrog taste receptor cell.

Authors: T Tsunenari; T Kurahashi; A Kaneko
Journal: J Physiol Date: 1999-09-01 Impact factor: 5.182

10. Changes in IP3 and cytosolic Ca2+ in response to sugars and non-sugar sweeteners in transduction of sweet taste in the rat.

Authors: S J Bernhardt; M Naim; U Zehavi; B Lindemann
Journal: J Physiol Date: 1996-01-15 Impact factor: 5.182

Localization of phosphatidylinositol signaling components in rat taste cells: role in bitter taste transduction.

1. ABNORMALITIES OF TASTE AND SMELL THRESHOLDS IN FAMILIAL DYSAUTONOMIA: IMPROVEMENT WITH METHACHOLINE.

Review 2. Cholinergic systems in non-nervous tissues.

3. The effects of transection of the glossopharyngeal nerve on the taste buds of the circumvallate papilla of the rat.

4. Salt taste transduction occurs through an amiloride-sensitive sodium transport pathway.

5. Amiloride reduces the taste intensity of Na+ and Li+ salts and sweeteners.

6. Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands.

7. Treatment of familial dysautonomia with bethanecol (urecholine).

8. ABSENCE OF TASTE-BUD PAPILLAE IN FAMILIAL DYSAUTONOMIA.

9. Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides.

10. The fine structure of von Ebner's gland of the rat.

1. Activation by bitter substances of a cationic channel in membrane patches excised from the bullfrog taste receptor cell.

2. Taste receptor cells that discriminate between bitter stimuli.

3. Bitter taste transduction of denatonium in the mudpuppy Necturus maculosus.

4. Expression of P2Y1 receptors in rat taste buds.

5. The taste of monosodium glutamate: membrane receptors in taste buds.

6. Effect of extracellular Ca2+ on the quinine-activated current of bullfrog taste receptor cells.

7. PLCbeta2-independent behavioral avoidance of prototypical bitter-tasting ligands.

8. Some taste substances are direct activators of G-proteins.

9. Intracellular Ca2+ and the phospholipid PIP2 regulate the taste transduction ion channel TRPM5.

10. Changes in IP3 and cytosolic Ca2+ in response to sugars and non-sugar sweeteners in transduction of sweet taste in the rat.