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Literature DB >> 21967146

Histone deacetylase inhibitors from Burkholderia thailandensis.

Paul Klausmeyer¹, Suzanne M Shipley, Karina M Zuck, Thomas G McCloud.

Abstract

Bioactivity-guided fractionation of an extract of Burkholderia thailandensis led to the isolation and identification of a new cytotoxic depsipeptide and its dimer. Both compounds potently inhibited the function of histone deacetylases 1 and 4. The monomer, spiruchostatin C (2), was tested side by side with the clinical depsipeptide FK228 (1, Istodax, romidepsin) in a murine hollow fiber assay consisting of 12 implanted tumor cell lines. Spiruchostatin C (2) showed good activity toward LOX IMVI melanoma cells and NCI-H522 non small cell lung cancer cells. Overall, however, FK228 (1) showed a superior in vivo antitumor profile in comparison to the new compound.

Entities: CellLine Chemical Disease Gene Species

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Year: 2011 PMID： 21967146 PMCID： PMC3204006 DOI： 10.1021/np200532d

Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050

17 in total

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Authors: Robert H Shoemaker
Journal: Nat Rev Cancer Date: 2006-10 Impact factor: 60.716

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Authors: Cheng Wang; Leonhard M Henkes; Leah B Doughty; Min He; Difei Wang; Franz-Josef Meyer-Almes; Yi-Qiang Cheng
Journal: J Nat Prod Date: 2011-07-27 Impact factor: 4.050

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11 in total

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Authors: Cheng Wang; Creston J Flemming; Yi-Qiang Cheng
Journal: Medchemcomm Date: 2012-08-01 Impact factor: 3.597

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Authors: Bumki Kim; Jiyong Hong
Journal: Curr Top Med Chem Date: 2015 Impact factor: 3.295

3. Revised genome sequence of Burkholderia thailandensis MSMB43 with improved annotation.

Authors: Ying Zhuo; Lin Liu; Qi Wang; Xiangyang Liu; Biao Ren; Mei Liu; Peixiang Ni; Yi-Qiang Cheng; Lixin Zhang
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Authors: Sylvia Kunakom; Alessandra S Eustáquio
Journal: J Nat Prod Date: 2019-07-11 Impact factor: 4.050

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Journal: J Nat Prod Date: 2013-03-21 Impact factor: 4.050

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Journal: Front Microbiol Date: 2016-12-21 Impact factor: 5.640

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Authors: Zhenfang Zhou; Xin Wang; Hui Zhang; Jingya Sun; Linghui Zheng; Hongchun Liu; Jidong Wang; Aijun Shen; Meiyu Geng; Yuewei Guo
Journal: Acta Pharm Sin B Date: 2015-01-07 Impact factor: 11.413