Literature DB >> 21834582

Chemical modification of siRNA bases to probe and enhance RNA interference.

Hayden Peacock1, Arunkumar Kannan, Peter A Beal, Cynthia J Burrows.   

Abstract

Considerable attention has focused on the use of alternatives to the native ribose and phosphate backbone of small interfering RNAs for therapeutic applications of the RNA interference pathway. In this synopsis, we highlight the less common chemical modifications, namely, those of the RNA nucleobases. Base modifications have the potential to lend insight into the mechanism of gene silencing and to lead to novel methods to overcome off-target effects that arise due to deleterious protein binding or mis-targeting of mRNA.
© 2011 American Chemical Society

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Year:  2011        PMID： 21834582      PMCID： PMC3170502          DOI： 10.1021/jo2012225

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  60 in total

1.  Functional anatomy of a dsRNA trigger: differential requirement for the two trigger strands in RNA interference.

Authors:  S Parrish; J Fleenor; S Xu; C Mello; A Fire
Journal:  Mol Cell       Date:  2000-11       Impact factor: 17.970

2.  Asymmetry in the assembly of the RNAi enzyme complex.

Authors:  Dianne S Schwarz; György Hutvágner; Tingting Du; Zuoshang Xu; Neil Aronin; Phillip D Zamore
Journal:  Cell       Date:  2003-10-17       Impact factor: 41.582

3.  Functional siRNAs and miRNAs exhibit strand bias.

Authors:  Anastasia Khvorova; Angela Reynolds; Sumedha D Jayasena
Journal:  Cell       Date:  2003-10-17       Impact factor: 41.582

Review 4.  RNA interference.

Authors:  Gregory J Hannon
Journal:  Nature       Date:  2002-07-11       Impact factor: 49.962

5.  siRNA function in RNAi: a chemical modification analysis.

Authors:  Ya-Lin Chiu; Tariq M Rana
Journal:  RNA       Date:  2003-09       Impact factor: 4.942

6.  Structural basis for recognition of the AGNN tetraloop RNA fold by the double-stranded RNA-binding domain of Rnt1p RNase III.

Authors:  Haihong Wu; Anthony Henras; Guillaume Chanfreau; Juli Feigon
Journal:  Proc Natl Acad Sci U S A       Date:  2004-05-18       Impact factor: 11.205

7.  Nucleobase and ribose modifications control immunostimulation by a microRNA-122-mimetic RNA.

Authors:  Hayden Peacock; Raymond V Fucini; Prasanna Jayalath; José M Ibarra-Soza; Henry J Haringsma; W Michael Flanagan; Aarron Willingham; Peter A Beal
Journal:  J Am Chem Soc       Date:  2011-06-01       Impact factor: 15.419

8.  Synthesis and studies on the effect of 2-thiouridine and 4-thiouridine on sugar conformation and RNA duplex stability.

Authors:  R K Kumar; D R Davis
Journal:  Nucleic Acids Res       Date:  1997-03-15       Impact factor: 16.971

9.  Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs.

Authors:  Gunter Meister; Markus Landthaler; Agnieszka Patkaniowska; Yair Dorsett; Grace Teng; Thomas Tuschl
Journal:  Mol Cell       Date:  2004-07-23       Impact factor: 17.970

10.  Small interfering RNAs mediate sequence-independent gene suppression and induce immune activation by signaling through toll-like receptor 3.

Authors:  Katalin Karikó; Prakash Bhuyan; John Capodici; Drew Weissman
Journal:  J Immunol       Date:  2004-06-01       Impact factor: 5.422
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  23 in total

1.  Steric restrictions of RISC in RNA interference identified with size-expanded RNA nucleobases.

Authors:  Armando R Hernández; Larryn W Peterson; Eric T Kool
Journal:  ACS Chem Biol       Date:  2012-06-12       Impact factor: 5.100

2.  Probing the inherent stability of siRNA immobilized on nanoparticle constructs.

Authors:  Stacey N Barnaby; Andrew Lee; Chad A Mirkin
Journal:  Proc Natl Acad Sci U S A       Date:  2014-06-19       Impact factor: 11.205

3.  Tuning RNA Interference by Enhancing siRNA/PAZ Recognition.

Authors:  Maria Gaglione; Nicoletta Potenza; Giovanni Di Fabio; Valeria Romanucci; Nicola Mosca; Aniello Russo; Ettore Novellino; Sandro Cosconati; Anna Messere
Journal:  ACS Med Chem Lett       Date:  2012-11-16       Impact factor: 4.345

4.  Short interfering RNA guide strand modifiers from computational screening.

Authors:  Kazumitsu Onizuka; Jason G Harrison; Alexi A Ball-Jones; José M Ibarra-Soza; Yuxuan Zheng; Diana Ly; Walter Lam; Stephanie Mac; Dean J Tantillo; Peter A Beal
Journal:  J Am Chem Soc       Date:  2013-11-05       Impact factor: 15.419

5.  Cellular activity of siRNA oligonucleotides containing synthetic isomorphic nucleoside surrogates.

Authors:  Dongwon Shin; Peter Lönn; Steven F Dowdy; Yitzhak Tor
Journal:  Chem Commun (Camb)       Date:  2015-01-31       Impact factor: 6.222

6.  Promiscuous 8-alkoxyadenosines in the guide strand of an siRNA: modulation of silencing efficacy and off-pathway protein binding.

Authors:  Uday Ghanty; Erik Fostvedt; Rachel Valenzuela; Peter A Beal; Cynthia J Burrows
Journal:  J Am Chem Soc       Date:  2012-10-11       Impact factor: 15.419

7.  Base modification strategies to modulate immune stimulation by an siRNA.

Authors:  Rachel Anne P Valenzuela; Scott R Suter; Alexi A Ball-Jones; José M Ibarra-Soza; Yuxuan Zheng; Peter A Beal
Journal:  Chembiochem       Date:  2014-12-08       Impact factor: 3.164

8.  Therapeutic Potential of OMe-PS-miR-29b1 for Treating Liver Fibrosis.

Authors:  Virender Kumar; Vinod Kumar; Jiangtao Luo; Ram I Mahato
Journal:  Mol Ther       Date:  2018-09-01       Impact factor: 11.454

9.  Development of Therapeutic-Grade Small Interfering RNAs by Chemical Engineering.

Authors:  Jesper B Bramsen; Jørgen Kjems
Journal:  Front Genet       Date:  2012-08-20       Impact factor: 4.599

10.  Synthesis and gene silencing properties of siRNAs containing terminal amide linkages.

Authors:  Maria Gaglione; M Emilia Mercurio; Nicoletta Potenza; Nicola Mosca; Aniello Russo; Ettore Novellino; Sandro Cosconati; Anna Messere
Journal:  Biomed Res Int       Date:  2014-03-26       Impact factor: 3.411
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