Literature DB >> 24900566

Tuning RNA Interference by Enhancing siRNA/PAZ Recognition.

Maria Gaglione1, Nicoletta Potenza1, Giovanni Di Fabio2, Valeria Romanucci2, Nicola Mosca1, Aniello Russo1, Ettore Novellino3, Sandro Cosconati1, Anna Messere1.   

Abstract

Chemically modified siRNAs were synthesized to enhance the corresponding silencing activities. The introduced modifications endowed siRNAs with high silencing effect, long RNAi persistence, and better serum resistance. Theoretical data allowed us to correlate the observed siRNAs interfering performance with the peculiar interactions with PAZ.

Keywords:  RNA interference; gene silencing; modified siRNAs; molecular modeling; siRNA/PAZ interactions

Year:  2012        PMID： 24900566      PMCID： PMC4027432          DOI： 10.1021/ml300284b

Source DB:  PubMed          Journal:  ACS Med Chem Lett        ISSN： 1948-5875            Impact factor:   4.345


  19 in total

1.  Modified siRNAs for the study of the PAZ domain.

Authors:  Alvaro Somoza; Montserrat Terrazas; Ramón Eritja
Journal:  Chem Commun (Camb)       Date:  2010-05-19       Impact factor: 6.222

Review 2.  Perspective: machines for RNAi.

Authors:  Yukihide Tomari; Phillip D Zamore
Journal:  Genes Dev       Date:  2005-03-01       Impact factor: 11.361

3.  Solid-phase synthesis of cyclic PNA and PNA-DNA chimeras.

Authors:  Loredana Moggio; Lorenzo De Napoli; Benedetto Di Blasio; Giovanni Di Fabio; Jennifer D'Onofrio; Daniela Montesarchio; Anna Messere
Journal:  Org Lett       Date:  2006-05-11       Impact factor: 6.005

4.  Cleavage of the siRNA passenger strand during RISC assembly in human cells.

Authors:  Philipp J F Leuschner; Stefan L Ameres; Stephanie Kueng; Javier Martinez
Journal:  EMBO Rep       Date:  2006-01-20       Impact factor: 8.807

5.  Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans.

Authors:  A Fire; S Xu; M K Montgomery; S A Kostas; S E Driver; C C Mello
Journal:  Nature       Date:  1998-02-19       Impact factor: 49.962

6.  Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras.

Authors:  James O McNamara; Eran R Andrechek; Yong Wang; Kristi D Viles; Rachel E Rempel; Eli Gilboa; Bruce A Sullenger; Paloma H Giangrande
Journal:  Nat Biotechnol       Date:  2006-06-25       Impact factor: 54.908

7.  Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells.

Authors:  S M Elbashir; J Harborth; W Lendeckel; A Yalcin; K Weber; T Tuschl
Journal:  Nature       Date:  2001-05-24       Impact factor: 49.962

8.  Synthesis of nuclease-resistant siRNAs possessing universal overhangs.

Authors:  Yoshihito Ueno; Yuuji Watanabe; Aya Shibata; Kayo Yoshikawa; Takashi Takano; Michinori Kohara; Yukio Kitade
Journal:  Bioorg Med Chem       Date:  2009-01-21       Impact factor: 3.641

9.  Effect of asymmetric terminal structures of short RNA duplexes on the RNA interference activity and strand selection.

Authors:  Masayuki Sano; Malgorzata Sierant; Makoto Miyagishi; Mahito Nakanishi; Yasuomi Takagi; Shizuyo Sutou
Journal:  Nucleic Acids Res       Date:  2008-09-09       Impact factor: 16.971

10.  RNA interference in mammalia cells by RNA-3'-PNA chimeras.

Authors:  Nicoletta Potenza; Loredana Moggio; Giovanna Milano; Vincenzo Salvatore; Benedetto Di Blasio; Aniello Russo; Anna Messere
Journal:  Int J Mol Sci       Date:  2008-03-12       Impact factor: 6.208
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  3 in total

1.  Tuning response curves for synthetic biology.

Authors:  Jordan Ang; Edouard Harris; Brendan J Hussey; Richard Kil; David R McMillen
Journal:  ACS Synth Biol       Date:  2013-09-03       Impact factor: 5.110

2.  Synthesis and gene silencing properties of siRNAs containing terminal amide linkages.

Authors:  Maria Gaglione; M Emilia Mercurio; Nicoletta Potenza; Nicola Mosca; Aniello Russo; Ettore Novellino; Sandro Cosconati; Anna Messere
Journal:  Biomed Res Int       Date:  2014-03-26       Impact factor: 3.411

3.  Exploring PAZ/3'-overhang interaction to improve siRNA specificity. A combined experimental and modeling study.

Authors:  Adele Alagia; Andreia F Jorge; Anna Aviñó; Tânia F G G Cova; Ramon Crehuet; Santiago Grijalvo; Alberto A C C Pais; Ramon Eritja
Journal:  Chem Sci       Date:  2018-01-15       Impact factor: 9.825
  3 in total

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