Literature DB >> 25500944

Cellular activity of siRNA oligonucleotides containing synthetic isomorphic nucleoside surrogates.

Dongwon Shin1, Peter Lönn, Steven F Dowdy, Yitzhak Tor.   

Abstract

Singly and multiply modified synthetic siRNA oligonucleotides, containing isomorphic surrogate nucleobases, show high interference potency in cell culture, suggesting the highly isomorphic RNA alphabet, based on a thieno[3,4-d]-pyrimidine core, is tolerated well by the cellular silencing machinery.

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Year:  2015        PMID： 25500944      PMCID： PMC4298453          DOI： 10.1039/c4cc08809c

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  25 in total

Review 1.  RNA interference.

Authors:  Gregory J Hannon
Journal:  Nature       Date:  2002-07-11       Impact factor: 49.962

Review 2.  Systematic genome-wide screens of gene function.

Authors:  Anne E Carpenter; David M Sabatini
Journal:  Nat Rev Genet       Date:  2004-01       Impact factor: 53.242

Review 3.  Mechanisms of gene silencing by double-stranded RNA.

Authors:  Gunter Meister; Thomas Tuschl
Journal:  Nature       Date:  2004-09-16       Impact factor: 49.962

Review 4.  Revealing the world of RNA interference.

Authors:  Craig C Mello; Darryl Conte
Journal:  Nature       Date:  2004-09-16       Impact factor: 49.962

Review 5.  siRNAs: applications in functional genomics and potential as therapeutics.

Authors:  Yair Dorsett; Thomas Tuschl
Journal:  Nat Rev Drug Discov       Date:  2004-04       Impact factor: 84.694

Review 6.  Building mammalian signalling pathways with RNAi screens.

Authors:  Jason Moffat; David M Sabatini
Journal:  Nat Rev Mol Cell Biol       Date:  2006-03       Impact factor: 94.444

7.  Emissive RNA alphabet.

Authors:  Dongwon Shin; Renatus W Sinkeldam; Yitzhak Tor
Journal:  J Am Chem Soc       Date:  2011-09-02       Impact factor: 15.419

8.  Thieno analogues of RNA nucleosides: a detailed theoretical study.

Authors:  Pralok K Samanta; Arun K Manna; Swapan K Pati
Journal:  J Phys Chem B       Date:  2012-06-25       Impact factor: 2.991

9.  Enzymatic interconversion of isomorphic fluorescent nucleosides: adenosine deaminase transforms an adenosine analogue into an inosine analogue.

Authors:  Renatus W Sinkeldam; Lisa S McCoy; Dongwon Shin; Yitzhak Tor
Journal:  Angew Chem Int Ed Engl       Date:  2013-11-29       Impact factor: 15.336

10.  Isomorphic emissive GTP surrogate facilitates initiation and elongation of in vitro transcription reactions.

Authors:  Lisa S McCoy; Dongwon Shin; Yitzhak Tor
Journal:  J Am Chem Soc       Date:  2014-10-17       Impact factor: 15.419
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  4 in total

1.  Fluorescence Turn-On Sensing of DNA Duplex Formation by a Tricyclic Cytidine Analogue.

Authors:  Dillon D Burns; Kristine L Teppang; Raymond W Lee; Melissa E Lokensgard; Byron W Purse
Journal:  J Am Chem Soc       Date:  2017-01-20       Impact factor: 15.419

2.  Chemoenzymatic synthesis and utilization of a SAM analog with an isomorphic nucleobase.

Authors:  C Vranken; A Fin; P Tufar; J Hofkens; M D Burkart; Y Tor
Journal:  Org Biomol Chem       Date:  2016-06-06       Impact factor: 3.876

3.  What Makes Thienoguanosine an Outstanding Fluorescent DNA Probe?

Authors:  Jagannath Kuchlyan; Lara Martinez-Fernandez; Mattia Mori; Krishna Gavvala; Stefano Ciaco; Christian Boudier; Ludovic Richert; Pascal Didier; Yitzhak Tor; Roberto Improta; Yves Mély
Journal:  J Am Chem Soc       Date:  2020-09-23       Impact factor: 15.419

4.  Deciphering the pH-dependence of ground- and excited-state equilibria of thienoguanine.

Authors:  Pascal Didier; Jagannath Kuchlyan; Lara Martinez-Fernandez; Pauline Gosset; Jérémie Léonard; Yitzhak Tor; Roberto Improta; Yves Mély
Journal:  Phys Chem Chem Phys       Date:  2020-03-25       Impact factor: 3.676
  4 in total

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