Literature DB >> 21612237

Nucleobase and ribose modifications control immunostimulation by a microRNA-122-mimetic RNA.

Hayden Peacock1, Raymond V Fucini, Prasanna Jayalath, José M Ibarra-Soza, Henry J Haringsma, W Michael Flanagan, Aarron Willingham, Peter A Beal.   

Abstract

Immune stimulation is a significant hurdle in the development of effective and safe RNA interference therapeutics. Here, we address this problem in the context of a mimic of microRNA-122 by employing novel nucleobase and known 2'-ribose modifications. The nucleobase modifications are analogues of adenosine and guanosine that contain cyclopentyl and propyl minor-groove projections. Via a site-by-site chemical modification analysis, we identify several immunostimulatory 'hot spots' within the miRNA guide strand at which single base modifications significantly reduce immune stimulation. A duplex containing one base modification on each strand proved to be most effective in preventing immune stimulation.

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Year:  2011        PMID： 21612237      PMCID： PMC3116021          DOI： 10.1021/ja202492e

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  23 in total

1.  Sequences derived from self-RNA containing certain natural modifications act as suppressors of RNA-mediated inflammatory immune responses.

Authors:  Sibylle Tluk; Marion Jurk; Alexandra Forsbach; Risini Weeratna; Ulrike Samulowitz; Arthur M Krieg; Stefan Bauer; Jörg Vollmer
Journal:  Int Immunol       Date:  2009-03-30       Impact factor: 4.823

2.  Evaluation of efficacy, biodistribution, and inflammation for a potent siRNA nanoparticle: effect of dexamethasone co-treatment.

Authors:  Marc T Abrams; Martin L Koser; Jessica Seitzer; Stephanie C Williams; Martha A DiPietro; Weimin Wang; Andrew W Shaw; Xianzhi Mao; Vasant Jadhav; Joseph P Davide; Paul A Burke; Alan B Sachs; Steven M Stirdivant; Laura Sepp-Lorenzino
Journal:  Mol Ther       Date:  2009-09-08       Impact factor: 11.454

3.  MicroRNA-122, a tumor suppressor microRNA that regulates intrahepatic metastasis of hepatocellular carcinoma.

Authors:  Wei-Chih Tsai; Paul Wei-Che Hsu; Tsung-Ching Lai; Gar-Yang Chau; Ching-Wen Lin; Chun-Ming Chen; Chien-Der Lin; Yu-Lun Liao; Jui-Ling Wang; Yat-Pang Chau; Ming-Ta Hsu; Michael Hsiao; Hsien-Da Huang; Ann-Ping Tsou
Journal:  Hepatology       Date:  2009-05       Impact factor: 17.425

4.  Modifications in small interfering RNA that separate immunostimulation from RNA interference.

Authors:  Florian Eberle; Kerstin Giessler; Christopher Deck; Klaus Heeg; Mirjam Peter; Clemens Richert; Alexander H Dalpke
Journal:  J Immunol       Date:  2008-03-01       Impact factor: 5.422

5.  Loss of miR-122 expression in liver cancer correlates with suppression of the hepatic phenotype and gain of metastatic properties.

Authors:  C Coulouarn; V M Factor; J B Andersen; M E Durkin; S S Thorgeirsson
Journal:  Oncogene       Date:  2009-07-20       Impact factor: 9.867

6.  Sequence- and target-independent angiogenesis suppression by siRNA via TLR3.

Authors:  Mark E Kleinman; Kiyoshi Yamada; Atsunobu Takeda; Vasu Chandrasekaran; Miho Nozaki; Judit Z Baffi; Romulo J C Albuquerque; Satoshi Yamasaki; Masahiro Itaya; Yuzhen Pan; Binoy Appukuttan; Daniel Gibbs; Zhenglin Yang; Katalin Karikó; Balamurali K Ambati; Traci A Wilgus; Luisa A DiPietro; Eiji Sakurai; Kang Zhang; Justine R Smith; Ethan W Taylor; Jayakrishna Ambati
Journal:  Nature       Date:  2008-03-26       Impact factor: 49.962

7.  Suppression of immunostimulatory siRNA-driven innate immune activation by 2'-modified RNAs.

Authors:  Mouldy Sioud; Gro Furset; Lina Cekaite
Journal:  Biochem Biophys Res Commun       Date:  2007-07-16       Impact factor: 3.575

8.  MicroRNA-122 inhibits tumorigenic properties of hepatocellular carcinoma cells and sensitizes these cells to sorafenib.

Authors:  Shoumei Bai; Mohd W Nasser; Bo Wang; Shu-Hao Hsu; Jharna Datta; Huban Kutay; Arti Yadav; Gerard Nuovo; Pawan Kumar; Kalpana Ghoshal
Journal:  J Biol Chem       Date:  2009-09-02       Impact factor: 5.157

9.  N(2)-Modified 2-aminopurine ribonucleosides as minor-groove-modulating adenosine replacements in duplex RNA.

Authors:  Hayden Peacock; Olena Maydanovych; Peter A Beal
Journal:  Org Lett       Date:  2010-03-05       Impact factor: 6.005

10.  Analysis of acyclic nucleoside modifications in siRNAs finds sensitivity at position 1 that is restored by 5'-terminal phosphorylation both in vitro and in vivo.

Authors:  Denise M Kenski; Abby J Cooper; Jenny J Li; Aarron T Willingham; Henry J Haringsma; Tracy A Young; Nelly A Kuklin; Jeffrey J Jones; Mark T Cancilla; Daniel R McMasters; Melina Mathur; Alan B Sachs; W Michael Flanagan
Journal:  Nucleic Acids Res       Date:  2009-11-16       Impact factor: 16.971
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  27 in total

Review 1.  Novel modifications in RNA.

Authors:  Kelly Phelps; Alexi Morris; Peter A Beal
Journal:  ACS Chem Biol       Date:  2011-12-23       Impact factor: 5.100

Review 2.  In vivo delivery of miRNAs for cancer therapy: challenges and strategies.

Authors:  Yunching Chen; Dong-Yu Gao; Leaf Huang
Journal:  Adv Drug Deliv Rev       Date:  2014-05-22       Impact factor: 15.470

Review 3.  Chemical modification of siRNA bases to probe and enhance RNA interference.

Authors:  Hayden Peacock; Arunkumar Kannan; Peter A Beal; Cynthia J Burrows
Journal:  J Org Chem       Date:  2011-08-17       Impact factor: 4.354

Review 4.  The emerging roles of microRNAs in CNS injuries.

Authors:  Oneil G Bhalala; Maya Srikanth; John A Kessler
Journal:  Nat Rev Neurol       Date:  2013-04-16       Impact factor: 42.937

5.  TLR8 activation and inhibition by guanosine analogs in RNA: Importance of functional groups and chain length.

Authors:  Tiannan Hu; Scott R Suter; Madeline M Mumbleau; Peter A Beal
Journal:  Bioorg Med Chem       Date:  2017-11-11       Impact factor: 3.641

6.  Short interfering RNA guide strand modifiers from computational screening.

Authors:  Kazumitsu Onizuka; Jason G Harrison; Alexi A Ball-Jones; José M Ibarra-Soza; Yuxuan Zheng; Diana Ly; Walter Lam; Stephanie Mac; Dean J Tantillo; Peter A Beal
Journal:  J Am Chem Soc       Date:  2013-11-05       Impact factor: 15.419

Review 7.  Tuning the size, shape and structure of RNA nanoparticles for favorable cancer targeting and immunostimulation.

Authors:  Sijin Guo; Congcong Xu; Hongran Yin; Jordan Hill; Fengmei Pi; Peixuan Guo
Journal:  Wiley Interdiscip Rev Nanomed Nanobiotechnol       Date:  2019-08-27

Review 8.  The code of non-coding RNAs in lung fibrosis.

Authors:  Huachun Cui; Na Xie; Victor J Thannickal; Gang Liu
Journal:  Cell Mol Life Sci       Date:  2015-05-31       Impact factor: 9.261

Review 9.  MicroRNA replacement therapy for cancer.

Authors:  Jon C Henry; Ana Clara P Azevedo-Pouly; Thomas D Schmittgen
Journal:  Pharm Res       Date:  2011-08-31       Impact factor: 4.200

10.  Base modification strategies to modulate immune stimulation by an siRNA.

Authors:  Rachel Anne P Valenzuela; Scott R Suter; Alexi A Ball-Jones; José M Ibarra-Soza; Yuxuan Zheng; Peter A Beal
Journal:  Chembiochem       Date:  2014-12-08       Impact factor: 3.164
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