Literature DB >> 217301

Effect of 9-(2-hydroxyethoxymethyl)guanine on herpesvirus-induced keratitis and iritis in rabbits.

H E Kaufman, E D Varnell, Y M Centifanto, S D Rheinstrom.   

Abstract

Drugs used for the inhibition of DNA viruses, such as iododeoxyuridine, adenine arabinoside, or trifluorothymidine, are not biochemically selective in their action and also interfere with normal cellular functions. The recently reported 9-(2-hydroxyethoxymethyl)guanine (acycloguanosine) is selectively phosphorylated by viral thymidine kinase but not by normal cellular thymidine kinase. Our present studies show that the acycloguanosine is as effective in treating herpetic keratitis in the rabbit as iododeoxyuridine and trifluorothymidine when given topically as an ointment. It is also effective when given intravenously for the treatment of herpetic iritis and is effective in preventing death from encephalitis in rabbits.

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Year:  1978        PMID： 217301      PMCID： PMC352567          DOI： 10.1128/AAC.14.6.842

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  9 in total

1.  Clinical cure of herpes simplex keratitis by 5-iodo-2-deoxyuridine.

Authors:  H E KAUFMAN
Journal:  Proc Soc Exp Biol Med       Date:  1962-02

2.  5-Halogenated analogs of deoxycytidine as selective inhibitors of the replication of herpes simplex viruses in cell culture and related studies of intracranial herpes simplex virus infections in mice.

Authors:  S Greer; I Schildkraut; T Zimmerman; H Kaufman
Journal:  Ann N Y Acad Sci       Date:  1975-08-08       Impact factor: 5.691

3.  Therapy of experimental herpes simplex keratitis in rabbits with 5-lodo-5'-amino-2',5'-dideoxyuridine (39882).

Authors:  C A Puliafito; N L Robinson; D M Albert; D Pavan-Langston; T S Lin; D C Ward; W H Prusoff
Journal:  Proc Soc Exp Biol Med       Date:  1977-10

4.  Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine.

Authors:  G B Elion; P A Furman; J A Fyfe; P de Miranda; L Beauchamp; H J Schaeffer
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

5.  9-(2-hydroxyethoxymethyl) guanine activity against viruses of the herpes group.

Authors:  H J Schaeffer; L Beauchamp; P de Miranda; G B Elion; D J Bauer; P Collins
Journal:  Nature       Date:  1978-04-13       Impact factor: 49.962

6.  A double blind clinical study of adenine arabinoside therapy of viral keratoconjunctivitis.

Authors:  D Pavan-Langston; C H Dohlman
Journal:  Am J Ophthalmol       Date:  1972-07       Impact factor: 5.258

7.  Intravenous adenine arabinoside against herpes simplex keratouveitis in humans.

Authors:  R Abel; H E Kaufman; J Sugar
Journal:  Am J Ophthalmol       Date:  1975-04       Impact factor: 5.258

8.  Adenine arabinoside therapy of biopsy-proved herpes simplex encephalitis. National Institute of Allergy and Infectious Diseases collaborative antiviral study.

Authors:  R J Whitley; S J Soong; R Dolin; G J Galasso; L T Ch'ien; C A Alford
Journal:  N Engl J Med       Date:  1977-08-11       Impact factor: 91.245

9.  THERAPEUTIC ANTIVIRAL ACTION OF 5-TRIFLUOROMETHYL-2'-DEOXYURIDINE IN HERPES SIMPLEX KERATITIS.

Authors:  H E KAUFMAN; C HEIDELBERGER
Journal:  Science       Date:  1964-08-07       Impact factor: 47.728
  9 in total
  20 in total

1.  Quantitation of herpes simplex virus type 1 shed in preocular tear film of rabbits treated with acyclovir.

Authors:  M T Green; E C Dunkel; B L Morris
Journal:  Antimicrob Agents Chemother       Date:  1981-11       Impact factor: 5.191

Review 2.  Recurrent herpes simplex: the outlook for systemic antiviral agents.

Authors:  H J Field; P Wildy
Journal:  Br Med J (Clin Res Ed)       Date:  1981-06-06

3.  In vitro susceptibility of varicella-zoster virus to acyclovir.

Authors:  K K Biron; G B Elion
Journal:  Antimicrob Agents Chemother       Date:  1980-09       Impact factor: 5.191

4.  Effects of prolonged cultivation in the presence of acyclovir on recovery of latent herpes simplex virus from human trigeminal ganglia.

Authors:  M E Lewis; K G Warren; V M Jeffrey; D L Tyrrell
Journal:  Antimicrob Agents Chemother       Date:  1983-03       Impact factor: 5.191

5.  A double-controlled evaluation of acyclovir and vidarabine for the treatment of herpes simplex epithelial keratitis.

Authors:  W R Yeakley; P R Laibson; M A Michelson; J J Arentsen
Journal:  Trans Am Ophthalmol Soc       Date:  1981

6.  Comparative in vitro imunotoxicology of acyclovir and other antiviral agents.

Authors:  R W Steele; D J Marmer; R E Keeney
Journal:  Infect Immun       Date:  1980-06       Impact factor: 3.441

7.  Combined antiviral effect of interferon and acyclovir on herpes simplex virus types 1 and 2.

Authors:  T L Stanwick; R F Schinazi; D E Campbell; A J Nahmias
Journal:  Antimicrob Agents Chemother       Date:  1981-04       Impact factor: 5.191

8.  Acyclovir treatment in stromal herpetic keratitis.

Authors:  J A Oosterhuis; R van Ganswijk; J Versteeg
Journal:  Doc Ophthalmol       Date:  1983-12-15       Impact factor: 2.379

Review 9.  Trifluridine: a review of its antiviral activity and therapeutic use in the topical treatment of viral eye infections.

Authors:  A A Carmine; R N Brogden; R C Heel; T M Speight; G S Avery
Journal:  Drugs       Date:  1982-05       Impact factor: 9.546

10.  Acyclovir therapy of neonatal herpes simplex virus type 2 infections in rabbits.

Authors:  S E Sicher; J O Oh
Journal:  Antimicrob Agents Chemother       Date:  1981-10       Impact factor: 5.191
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