Literature DB >> 205792

9-(2-hydroxyethoxymethyl) guanine activity against viruses of the herpes group.

H J Schaeffer, L Beauchamp, P de Miranda, G B Elion, D J Bauer, P Collins.   

Abstract

Of a series of nucleoside analogues synthesised, 9-(2-hydroxyethoxymethyl) guanine was found to have marked antiviral activity in animal models of herpes virus infections, associated with very low toxicity.

Entities:  

Mesh：

Substances：

Year:  1978        PMID： 205792     DOI： 10.1038/272583a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  177 in total

Review 1.  HSV-1-based vectors for gene therapy of neurological diseases and brain tumors: part I. HSV-1 structure, replication and pathogenesis.

Authors:  A Jacobs; X O Breakefield; C Fraefel
Journal:  Neoplasia       Date:  1999-11       Impact factor: 5.715

2.  Variable R1 region in varicella zoster virus in fulminant type of acute retinal necrosis syndrome.

Authors:  T Abe; M Sato; M Tamai
Journal:  Br J Ophthalmol       Date:  2000-02       Impact factor: 4.638

3.  Pharmacokinetics of E-5-(2-bromovinyl)-2'-deoxyuridine in mice.

Authors:  E de Clercq; J Descamps; P de Somer; P J Barr; A S Jones; R T Walker
Journal:  Antimicrob Agents Chemother       Date:  1979-08       Impact factor: 5.191

4.  Tautomerism in drug discovery.

Authors:  Alan R Katritzky; C Dennis Hall; Bahaa El-Dien M El-Gendy; Bogdan Draghici
Journal:  J Comput Aided Mol Des       Date:  2010-05-20       Impact factor: 3.686

5.  Clinical evaluation of carbocyclic oxetanocin G eyedrops in the treatment of herpes simplex corneal ulcers.

Authors:  H Shiota; K Nitta; T Naito; Y Mimura; T Maruyama
Journal:  Br J Ophthalmol       Date:  1996-05       Impact factor: 4.638

6.  Nobel lecture in physiology or medicine--1988. The purine path to chemotherapy.

Authors:  G B Elion
Journal:  In Vitro Cell Dev Biol       Date:  1989-04

7.  Antiherpesvirus activity of 9-(4-hydroxy-3-hydroxymethylbut-1-yl) guanine (BRL 39123) in animals.

Authors:  M R Boyd; T H Bacon; D Sutton
Journal:  Antimicrob Agents Chemother       Date:  1988-03       Impact factor: 5.191

8.  6-Methoxypurine arabinoside as a selective and potent inhibitor of varicella-zoster virus.

Authors:  D R Averett; G W Koszalka; J A Fyfe; G B Roberts; D J Purifoy; T A Krenitsky
Journal:  Antimicrob Agents Chemother       Date:  1991-05       Impact factor: 5.191

Review 9.  Structure-activity relationships and conformational features of antiherpetic pyrimidine and purine nucleoside analogues. A review.

Authors:  T Kulikowski
Journal:  Pharm World Sci       Date:  1994-04-15

10.  Penetration of guinea pig skin by acyclovir in different vehicles and correlation with the efficacy of topical therapy of experimental cutaneous herpes simplex virus infection.

Authors:  S L Spruance; M B McKeough; J R Cardinal
Journal:  Antimicrob Agents Chemother       Date:  1984-01       Impact factor: 5.191
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.