Literature DB >> 6275777

Quantitation of herpes simplex virus type 1 shed in preocular tear film of rabbits treated with acyclovir.

M T Green, E C Dunkel, B L Morris.   

Abstract

The quantity and duration of herpes simplex virus type 1 shedding in the preocular tear film of rabbits were measured before, during, and after administration of acyclovir topically, intravenously, and by these routes. Topical administration reduced shedding significantly, Intravenous administration was without effect and in the combination regimen added nothing to the effectiveness of local application. The effects of acyclovir were temporary because there were significant increase in preocular tear film virus shedding after cessation of treatment.

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Year:  1981        PMID： 6275777      PMCID： PMC181754          DOI： 10.1128/AAC.20.5.580

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  16 in total

1.  IDU and cytosine arabinoside in experimental herpetic keratitis.

Authors:  H E KAUFMAN; E D MALONEY
Journal:  Arch Ophthalmol       Date:  1963-05

2.  Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine.

Authors:  G B Elion; P A Furman; J A Fyfe; P de Miranda; L Beauchamp; H J Schaeffer
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

3.  Effect of 9-(2-hydroxyethoxymethyl)guanine on herpesvirus-induced keratitis and iritis in rabbits.

Authors:  H E Kaufman; E D Varnell; Y M Centifanto; S D Rheinstrom
Journal:  Antimicrob Agents Chemother       Date:  1978-12       Impact factor: 5.191

4.  Acyclic antimetabolite therapy of experimental herpes simplex keratitis.

Authors:  D Pavan-Langston; R Campbell; J Lass
Journal:  Am J Ophthalmol       Date:  1978-11       Impact factor: 5.258

5.  Intravenous adenine arabinoside against herpes simplex keratouveitis in humans.

Authors:  R Abel; H E Kaufman; J Sugar
Journal:  Am J Ophthalmol       Date:  1975-04       Impact factor: 5.258

6.  Parenteral acyclovir therapy for herpesvirus infections in man.

Authors:  P J Selby; R L Powles; B Janeson; H E Kay; J G Watson; R Thornton; G Morgenstern; H M Clink; T J McElwain; H G Prentice; R Corringharn; M G Ross; A V Hoffbrand; D Brigden
Journal:  Lancet       Date:  1979-12-15       Impact factor: 79.321

7.  Treatment of experimental herpes simplex keratitis with acycloguanosine.

Authors:  D J Bauer; P Collins; W E Tucker; A W Macklin
Journal:  Br J Ophthalmol       Date:  1979-06       Impact factor: 4.638

8.  Toxicity and tolerance of 9-(2-hydroxyethoxymethyl)guanine.

Authors:  K S Morgan; A H Wander; H E Kaufman; E D Varnell; T Creagh-Kirk
Journal:  Chemotherapy       Date:  1980       Impact factor: 2.544

9.  Use of 5-iodo-2'-deoxyuridine (IDU) in treatment of herpes simplex keratitis.

Authors:  H KAUFMAN; E L MARTOLA; C DOHLMAN
Journal:  Arch Ophthalmol       Date:  1962-08

10.  Effect of acycloguanosine treatment of acute and latent herpes simplex infections in mice.

Authors:  H J Field; S E Bell; G B Elion; A A Nash; P Wildy
Journal:  Antimicrob Agents Chemother       Date:  1979-04       Impact factor: 5.191
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  1 in total

Review 1.  Acyclovir. A review of its pharmacodynamic properties and therapeutic efficacy.

Authors:  D M Richards; A A Carmine; R N Brogden; R C Heel; T M Speight; G S Avery
Journal:  Drugs       Date:  1983-11       Impact factor: 9.546
  1 in total

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