Literature DB >> 14163783

THERAPEUTIC ANTIVIRAL ACTION OF 5-TRIFLUOROMETHYL-2'-DEOXYURIDINE IN HERPES SIMPLEX KERATITIS.

H E KAUFMAN, C HEIDELBERGER.   

Abstract

5-Trifluoromethyl-2'-deoxyuridine (F(3)TDR) has potent therapeutic antiviral activity in herpes simplex infection of the rabbit cornea with strains of herpes virus both sensitive and resistant to 5-iodo-2'-deoxyuridine, and in corneal infection with vaccinia. 5-Trifluoromethyl uracil is not therapeutically active in herpetic keratitis.

Entities:  

Keywords:  ANTIVIRAL AGENTS; CORNEA; CORNEAL ULCER; EXPERIMENTAL LAB STUDY; IDOXURIDINE; KERATITIS, DENDRITIC; PHARMACOLOGY; RABBITS; ULCER; VACCINIA

Mesh：

Substances：

Year:  1964        PMID： 14163783     DOI： 10.1126/science.145.3632.585

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  31 in total

1.  Molecular structure and effects of intermolecular hydrogen bonding on the vibrational spectrum of trifluorothymine, an antitumor and antiviral agent.

Authors:  Cağrı Cırak; Nurettin Koç
Journal:  J Mol Model       Date:  2012-05-27       Impact factor: 1.810

2.  A human apolipoprotein E mimetic peptide effectively inhibits HSV-1 TK-positive and TK-negative acute epithelial keratitis in rabbits.

Authors:  Partha S Bhattacharjee; Donna M Neumann; James M Hill
Journal:  Curr Eye Res       Date:  2009-02       Impact factor: 2.424

3.  Evaluation of a peptidomimetic ribonucleotide reductase inhibitor with a murine model of herpes simplex virus type 1 ocular disease.

Authors:  C R Brandt; B Spencer; P Imesch; M Garneau; R Déziel
Journal:  Antimicrob Agents Chemother       Date:  1996-05       Impact factor: 5.191

4.  Effect of 9-(2-hydroxyethoxymethyl)guanine on herpesvirus-induced keratitis and iritis in rabbits.

Authors:  H E Kaufman; E D Varnell; Y M Centifanto; S D Rheinstrom
Journal:  Antimicrob Agents Chemother       Date:  1978-12       Impact factor: 5.191

5.  HEp-2 cell- and herpes simplex virus type 1- induced deoxythymidine kinases: inhibition by derivatives of 5-trifluoromethyl-2'-deoxyuridine.

Authors:  B L Wigdahl; J R Parkhurst
Journal:  Antimicrob Agents Chemother       Date:  1978-09       Impact factor: 5.191

Review 6.  Approved Antiviral Drugs over the Past 50 Years.

Authors:  Erik De Clercq; Guangdi Li
Journal:  Clin Microbiol Rev       Date:  2016-07       Impact factor: 26.132

7.  Phosphorylation of 5-bromodeoxycytidine in cells infected with herpes simplex virus.

Authors:  G M Cooper
Journal:  Proc Natl Acad Sci U S A       Date:  1973-12       Impact factor: 11.205

8.  [Virostatic effect and clinical use of 1-allyl-3,5-diethyl-6-chlorouracil].

Authors:  K K Gauri; B Rohde
Journal:  Klin Wochenschr       Date:  1969-04-01

Review 9.  Structure-activity relationships and conformational features of antiherpetic pyrimidine and purine nucleoside analogues. A review.

Authors:  T Kulikowski
Journal:  Pharm World Sci       Date:  1994-04-15

10.  Experimental herpes simplex virus type 1 encephalitis: treatment with 5-trifluoromethyl-2'-deoxyuridine.

Authors:  D W Clough; J R Parkhurst
Journal:  Antimicrob Agents Chemother       Date:  1977-02       Impact factor: 5.191
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