Literature DB >> 6303216

Effects of prolonged cultivation in the presence of acyclovir on recovery of latent herpes simplex virus from human trigeminal ganglia.

M E Lewis, K G Warren, V M Jeffrey, D L Tyrrell.   

Abstract

The continuous presence of acyclovir prevented the in vitro reactivation of latent herpes simplex virus from cultures of human trigeminal ganglia derived from 23 randomly selected cadavers. When acyclovir was withdrawn after 30 days, herpes simplex virus was recovered from 3 of 18 cases. Herpes simplex virus was recovered in 9 of 20 (45%) control cases.

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Year:  1983        PMID: 6303216      PMCID: PMC184675          DOI: 10.1128/AAC.23.3.487

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN: 0066-4804            Impact factor:   5.191


  24 in total

Review 1.  Herpes simplex virus infection of nervous tissue in animals and man.

Authors:  J R Baringer
Journal:  Prog Med Virol       Date:  1975

2.  Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine.

Authors:  G B Elion; P A Furman; J A Fyfe; P de Miranda; L Beauchamp; H J Schaeffer
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

3.  9-(2-hydroxyethoxymethyl) guanine activity against viruses of the herpes group.

Authors:  H J Schaeffer; L Beauchamp; P de Miranda; G B Elion; D J Bauer; P Collins
Journal:  Nature       Date:  1978-04-13       Impact factor: 49.962

4.  Effect of 9-(2-hydroxyethoxymethyl)guanine on herpesvirus-induced keratitis and iritis in rabbits.

Authors:  H E Kaufman; E D Varnell; Y M Centifanto; S D Rheinstrom
Journal:  Antimicrob Agents Chemother       Date:  1978-12       Impact factor: 5.191

5.  Acyclic antimetabolite therapy of experimental herpes simplex keratitis.

Authors:  D Pavan-Langston; R Campbell; J Lass
Journal:  Am J Ophthalmol       Date:  1978-11       Impact factor: 5.258

6.  Evidence that neurons harbor latent herpes simplex virus.

Authors:  M L Cook; V B Bastone; J G Stevens
Journal:  Infect Immun       Date:  1974-05       Impact factor: 3.441

7.  A rapid technique for distinguishing herpes-simplex virus type 1 from type 2 by restriction-enzyme technology.

Authors:  D M Lonsdale
Journal:  Lancet       Date:  1979-04-21       Impact factor: 79.321

8.  Recovery of latent herpes simplex virus from human trigeminal nerve roots.

Authors:  K G Warren; R G Marusyk; M E Lewis; V M Jeffrey
Journal:  Arch Virol       Date:  1982       Impact factor: 2.574

9.  Isolation of Herpes simplex virus from human trigeminal ganglia, including ganglia from one patient with multiple sclerosis.

Authors:  K G Warren; M Devlin; D H Gilden; Z Wroblewska; S M Brown; J Subak-Sharpe; H Koprowski
Journal:  Lancet       Date:  1977-09-24       Impact factor: 79.321

10.  Effect of acycloguanosine treatment of acute and latent herpes simplex infections in mice.

Authors:  H J Field; S E Bell; G B Elion; A A Nash; P Wildy
Journal:  Antimicrob Agents Chemother       Date:  1979-04       Impact factor: 5.191

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