Literature DB >> 2163604

Emerging approaches in the molecular design of receptor-selective peptide ligands: conformational, topographical and dynamic considerations.

V J Hruby1, F al-Obeidi, W Kazmierski.   

Abstract

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Year:  1990        PMID： 2163604      PMCID： PMC1131425          DOI： 10.1042/bj2680249

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


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  54 in total

1.  Design and synthesis of somatostatin analogues with topographical properties that lead to highly potent and specific mu opioid receptor antagonists with greatly reduced binding at somatostatin receptors.

Authors:  W Kazmierski; W S Wire; G K Lui; R J Knapp; J E Shook; T F Burks; H I Yamamura; V J Hruby
Journal:  J Med Chem       Date:  1988-11       Impact factor: 7.446

2.  Conformationally restricted analogues of atriopeptin(103-125)amide.

Authors:  K L Spear; E J Reinhard; E G McMahon; G M Olins; M A Palomo; D R Patton
Journal:  J Med Chem       Date:  1989-01       Impact factor: 7.446

3.  New delta-receptor antagonists.

Authors:  C W Thornber; J S Shaw; L Miller; C F Hayward; J S Morley; D Timms; A Wilkinson
Journal:  NIDA Res Monogr       Date:  1986

4.  Studies on angiotensin converting enzyme inhibitors. 4. Synthesis and angiotensin converting enzyme inhibitory activities of 3-acyl-1-alkyl-2-oxoimidazolidine-4-carboxylic acid derivatives.

Authors:  K Hayashi; K Nunami; J Kato; N Yoneda; M Kubo; T Ochiai; R Ishida
Journal:  J Med Chem       Date:  1989-02       Impact factor: 7.446

5.  Synthesis and conformational study of a cyclic hexapeptide analogue of somatostatin: cyclo(Phe-D-Trp-Lys-Thr-o-AMPA).

Authors:  P Vander Elst; E van den Berg; H Pepermans; L vander Auwera; R Zeeuws; D Tourwe; G van Binst
Journal:  Int J Pept Protein Res       Date:  1987-03

6.  Design of potent linear alpha-melanotropin 4-10 analogues modified in positions 5 and 10.

Authors:  F Al-Obeidi; V J Hruby; A M Castrucci; M E Hadley
Journal:  J Med Chem       Date:  1989-01       Impact factor: 7.446

7.  Synthesis, conformation, and immunosuppressive activity of a conformationally restricted cyclosporine lactam analogue.

Authors:  J D Aebi; D Guillaume; B E Dunlap; D H Rich
Journal:  J Med Chem       Date:  1988-09       Impact factor: 7.446

8.  Anticoagulant peptides: nature of the interaction of the C-terminal region of hirudin with a noncatalytic binding site on thrombin.

Authors:  J L Krstenansky; T J Owen; M T Yates; S J Mao
Journal:  J Med Chem       Date:  1987-09       Impact factor: 7.446

9.  Conformationally constrained renin inhibitory peptides: gamma-lactam-bridged dipeptide isostere as conformational restriction.

Authors:  S Thaisrivongs; D T Pals; S R Turner; L T Kroll
Journal:  J Med Chem       Date:  1988-07       Impact factor: 7.446

10.  Investigation of peripheral cholecystokinin receptor heterogeneity by cyclic and related linear analogues of CCK26-33: synthesis and biological properties.

Authors:  B Charpentier; C Durieux; I Menant; B P Roques
Journal:  J Med Chem       Date:  1987-06       Impact factor: 7.446
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  50 in total

1.  Design of novel peptide ligands which have opioid agonist activity and CCK antagonist activity for the treatment of pain.

Authors:  V J Hruby; R S Agnes; P Davis; S-W Ma; Y S Lee; T W Vanderah; J Lai; F Porreca
Journal:  Life Sci       Date:  2003-06-27       Impact factor: 5.037

2.  Peptide bicycles that inhibit the Grb2 SH2 domain.

Authors:  Justin S Quartararo; Pianpian Wu; Joshua A Kritzer
Journal:  Chembiochem       Date:  2012-06-11       Impact factor: 3.164

3.  Active conformation of an insect neuropeptide family.

Authors:  R J Nachman; V A Roberts; H J Dyson; G M Holman; J A Tainer
Journal:  Proc Natl Acad Sci U S A       Date:  1991-05-15       Impact factor: 11.205

Review 4.  Inorganic nanoparticle-based contrast agents for molecular imaging.

Authors:  Eun Chul Cho; Charles Glaus; Jingyi Chen; Michael J Welch; Younan Xia
Journal:  Trends Mol Med       Date:  2010-11-10       Impact factor: 11.951

5.  Approaches to the rational design of selective melanocortin receptor antagonists.

Authors:  Victor J Hruby; Minying Cai; Joel Nyberg; Dhanasekaran Muthu
Journal:  Expert Opin Drug Discov       Date:  2011-03-24       Impact factor: 6.098

6.  Critical role in CXCR4 signaling and internalization of the polypeptide main chain in the amino terminus of SDF-1α probed by novel N-methylated synthetically and modularly modified chemokine analogues.

Authors:  Chang-Zhi Dong; Shaomin Tian; Won-Tak Choi; Santhosh Kumar; Dongxiang Liu; Yan Xu; Xiaofeng Han; Ziwei Huang; Jing An
Journal:  Biochemistry       Date:  2012-07-23       Impact factor: 3.162

7.  Universal peptidomimetics.

Authors:  Eunhwa Ko; Jing Liu; Lisa M Perez; Genliang Lu; Amber Schaefer; Kevin Burgess
Journal:  J Am Chem Soc       Date:  2010-12-23       Impact factor: 15.419

8.  Structure-lipophilicity relationships of peptides and peptidomimetics.

Authors:  N El Tayar; H Karajiannis; H van de Waterbeemd
Journal:  Amino Acids       Date:  1995-06       Impact factor: 3.520

9.  Synthesis and evaluation of new endomorphin-2 analogues containing (Z)-alpha,beta-didehydrophenylalanine (Delta(Z)Phe) residues.

Authors:  Domenica Torino; Adriano Mollica; Francesco Pinnen; Federica Feliciani; Gino Lucente; Giancarlo Fabrizi; Gustavo Portalone; Peg Davis; Josephine Lai; Shou-Wu Ma; Frank Porreca; Victor J Hruby
Journal:  J Med Chem       Date:  2010-06-10       Impact factor: 7.446

10.  Adventures in peptides and science with students! The joys of research.

Authors:  Victor J Hruby
Journal:  Biopolymers       Date:  2013-04       Impact factor: 2.505
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