Literature DB >> 23616095

Adventures in peptides and science with students! The joys of research.

Victor J Hruby1.   

Abstract

Working with students at the undergraduate, graduate and postdoctoral levels has brought me great joy and satisfaction. Each student is a unique human being, so each provides an important opportunity for learning, creativity and accomplishment in research and scholarship. In this reflection, several examples of this scientific process are discussed in the context of solving scientific problems which led to novel and critical scientific insights.
Copyright © 2012 Wiley Periodicals, Inc.

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Year:  2013        PMID： 23616095      PMCID： PMC3967710          DOI： 10.1002/bip.22179

Source DB:  PubMed          Journal:  Biopolymers        ISSN： 0006-3525            Impact factor:   2.505


  21 in total

1.  Design of novel peptide ligands which have opioid agonist activity and CCK antagonist activity for the treatment of pain.

Authors:  V J Hruby; R S Agnes; P Davis; S-W Ma; Y S Lee; T W Vanderah; J Lai; F Porreca
Journal:  Life Sci       Date:  2003-06-27       Impact factor: 5.037

2.  alpha-Melanotropin: the minimal active sequence in the frog skin bioassay.

Authors:  V J Hruby; B C Wilkes; M E Hadley; F Al-Obeidi; T K Sawyer; D J Staples; A E de Vaux; O Dym; A M Castrucci; M F Hintz
Journal:  J Med Chem       Date:  1987-11       Impact factor: 7.446

Review 3.  Emerging approaches in the molecular design of receptor-selective peptide ligands: conformational, topographical and dynamic considerations.

Authors:  V J Hruby; F al-Obeidi; W Kazmierski
Journal:  Biochem J       Date:  1990-06-01       Impact factor: 3.857

Review 4.  Melanotropic peptides for therapeutic and cosmetic tanning of the skin.

Authors:  M E Hadley; S D Sharma; V J Hruby; N Levine; R T Dorr
Journal:  Ann N Y Acad Sci       Date:  1993-05-31       Impact factor: 5.691

5.  Expression-driven reverse engineering of targeted imaging and therapeutic agents.

Authors:  Robert J Gillies; Victor J Hruby
Journal:  Expert Opin Ther Targets       Date:  2003-04       Impact factor: 6.902

6.  Potent and prolonged acting cyclic lactam analogues of alpha-melanotropin: design based on molecular dynamics.

Authors:  F Al-Obeidi; A M Castrucci; M E Hadley; V J Hruby
Journal:  J Med Chem       Date:  1989-12       Impact factor: 7.446

7.  Calcium-dependent prolonged effects on melanophores of [4-norleucine, 7-D-phenylalanine]-alpha-melanotropin.

Authors:  M E Hadley; B Anderson; C B Heward; T K Sawyer; V J Hruby
Journal:  Science       Date:  1981-08-28       Impact factor: 47.728

8.  Induction of skin tanning by subcutaneous administration of a potent synthetic melanotropin.

Authors:  N Levine; S N Sheftel; T Eytan; R T Dorr; M E Hadley; J C Weinrach; G A Ertl; K Toth; D L McGee; V J Hruby
Journal:  JAMA       Date:  1991-11-20       Impact factor: 56.272

9.  Decrease in macrophage antigen catabolism caused by ammonia and chloroquine is associated with inhibition of antigen presentation to T cells.

Authors:  H K Ziegler; E R Unanue
Journal:  Proc Natl Acad Sci U S A       Date:  1982-01       Impact factor: 11.205

10.  Cyclic lactam alpha-melanotropin analogues of Ac-Nle4-cyclo[Asp5, D-Phe7,Lys10] alpha-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin receptors.

Authors:  V J Hruby; D Lu; S D Sharma; A L Castrucci; R A Kesterson; F A al-Obeidi; M E Hadley; R D Cone
Journal:  J Med Chem       Date:  1995-09-01       Impact factor: 7.446
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